Frontal cortical tau pathology in aging humans is associated with reduced slow-wave travel during sleep. This reduced propagation is associated with poorer overnight memory retention, supporting a lin...

Two-photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task-related place cell activity and splitter cell trajectory coding are impaired, with ....

Recent studies have implicated dopaminergic signaling within the substantia nigra pars reticulata (SNr) in the emergence of Parkinsonian motor deficits. To better understand the mechanisms underlying ...

Levodopa restores the balance between exploration and exploitation in Parkinson’s disease.

INTRODUCTION Animal models demonstrated that pharmacologically-induced lesioning of the locus coeruleus (LC), the brain's primary source of norepinephrine, triggered astrocyte reactivity, exacerbati...

Understanding how signals are exchanged across the cerebral cortex is a central challenge for theories of perception and cognition. This Essay puts forward a roadmap for investigating cortical network...

Functional heterogeneity of dorsal raphe nucleus is not fully understood. Here authors show topographically organized sensory and locomotor responses from the zebrafish dorsal raphe and its forebrain ...

Predictive models have emerged as a normative lens for understanding neural function. In this Perspective, de Cothi, Shipley and Barry plausibly unify the diverse roles of hippocampal acetylcholine in...

Adaptive decision-making in dynamic environments requires flexible adjustment of learning speed to balance stability and flexibility. When outcomes...

A new study has uncovered how antidepressants affect different groups of serotonin-producing brain cells in opposite ways, offering new insights into why selective serotonin reuptake inhibitors (SSRIs) can cause unpleasant side effects at the start of treatment but lead to symptom relief over time.

Abstract. The hippocampus is involved in learning predictive associations, responding to prediction errors as well as representing predictions of future in

Abstract. Memories for temporally extended sequences can be used adaptively to predict future events on multiple timescales, a function that relies on the

Neuropsychopharmacology - Regulation of the decision threshold by the locus coeruleus

Using direct recordings from the human brain, Frank et al. show that hippocampal ripples increase ahead of unpredictable events and tune the visual cortex to respond faster and more strongly to surpri...

Neuropsychopharmacology - Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α

Molecular Psychiatry - A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms

Conscious error detection is accompanied by error-related changes in phasic autonomic activity. This autonomic response is diminished in older age – accompanied by impairments in the conscious detecti...

Postdoctoral opportunity to work on understanding the role of the noradrenergic system in Alzheimer's disease pathophysiology and symptoms. The focus is on integrating 3T and 7T MRI (sMRI, fMRI, MRS)...

Posted 12:31:04 AM. Postdoctoral Fellow – Neuroimaging, Network Neuroscience & AI/ML in Cognitive DisordersYassa Lab |…See this and similar jobs on LinkedIn.

During wakefulness, neuromodulators operate largely independently to support behavior and cognition. By contrast, sleep reorganizes their activity into a coordinated brain rhythm. During sleep, the ma...

The arrangement of locus coeruleus neurons in mice points to how the structure mediates specific effects across the brain, a new study shows.

This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.

People often find that memories linked to the same place or period come to mind together. Visiting a former workplace can prompt recall of events that had not been thought about for years, such as con...

Do you want to work as a PhD 'Computational Affective Neuroscience and Neuromodulation' at the Faculty of Social Sciences? Check our vacancy!

Neuropsychopharmacology - Computational phenotyping of effort-based decision-making in type-2 diabetes on and off semaglutide

The brain may use dopamine to expand time between distinct events, enabling us to remember unique episodes.