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Bernie Mulvey

@berniejmulvey.bsky.social
151 followers 349 following 31 posts

Postdoc at Lieber Institute for Brain Development. Brain molecular regul° and gene express° in health, mood disorders, and neurodegen (and sex diffs therein). Email: b[last name]1 at jh edu

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Bernie Mulvey @berniejmulvey.bsky.social · 01/10/2026
Impromptu field research lunch yesterday turned up a looooooooonnngggg kitten for adoption at Affogatto cat cafe
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Bernie Mulvey @berniejmulvey.bsky.social · 17/09/2026
Have some (a boatload) more LC! www.nature.com/articles/s41...
nature.com
Topographic structure and function of locus coeruleus noradrenaline neurons - Nature
Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...
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Bernie Mulvey @berniejmulvey.bsky.social · 11/09/2026
Excited to share work with cryostat wizard @heenadivecha.bsky.social looking at gene expression in my favorite brain region (LC) in adult postmortem brain! (Long URL to spare the trouble of identifying cars, buses, beds in 5x5 pixel imgs). (1/x) link.springer.com/epdf/10.1007...
link.springer.com
Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability
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Bernie Mulvey @berniejmulvey.bsky.social · 10/09/2026
Study the biology of sex hormones and sex differences, folks! (From this week's @bbrfoundation.bsky.social seminar by @clearlab.bsky.social )
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Reposted by Bernie Mulvey
Keri Martinowich @martinowk.bsky.social · 24/07/2026
For #FluorescenceFriday - maybe not the prettiest ever, but scientifically just super cool - zoom in to see DBH transcripts 🔵, marking noradrenergic neurons in locus coeruleus of human 🧠... w/ unexpected boatload of CARTPT 🔴. Image/data credits @berniejmulvey.bsky.social @heenadivecha.bsky.social
Image from Xenium spatial transcriptomics showing transcripts of dopamine beta hydroxylase (DBH), marking noradrenergic cells in a section of tissue at the level of the locus coeruleus in human brain, that are co-expressed with red transcripts marking CARTPT.
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Bernie Mulvey @berniejmulvey.bsky.social · 03/04/2026
Excited to share our spatial omics from hypothal. are out in Cell Rep--with more interactive data browsing coming soon w/ UCSC single-cell browser! @kr-maynard.bsky.social @kasperdhansen.bsky.social •Paper: www.cell.com/cell-reports... •UCSC (demo): cells-test.gi.ucsc.edu?ds=hypothala...
cell.com
Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus
The ventromedial hypothalamus (VMH) and arcuate (ARC) nuclei of the hypothalamus play critical roles in regulating metabolism and behavior. Here, Mulvey et al. create a focused spatial transcriptomic ...
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Reposted by Bernie Mulvey
Louise Huuki-Myers @lahuuki.bsky.social · 04/11/2025
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
doi.org
Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry
Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...
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Reposted by Bernie Mulvey
The Transmitter @thetransmitter.bsky.social · 16/10/2025
A large study of developing brains reveals genetic and molecular differences between males and females. The findings may help explain why neurodevelopmental conditions, including autism, occur at different rates in boys and girls. By @giorgiag-sciwriter.bsky.social bit.ly/4q9BsVH
bit.ly
Gene-activity map of developing brain reveals new clues about autism’s sex bias
Boys and girls may be vulnerable to different genetic changes, which could help explain why the condition is more common in boys despite linked variants appearing more often in girls.
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Bernie Mulvey @berniejmulvey.bsky.social · 01/11/2025
10/8: Any time you see two tissue sections, the other was the preceding or subsequent 10µm of tissue cut from the same donor, because @heenadivecha.bsky.social is a beast! As is the link to the browser with all 85 tissue sections available: samuibrowser.com/from?url=dat...
samuibrowser.com
Samui
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Bernie Mulvey @berniejmulvey.bsky.social · 01/11/2025
9/8: The high-res spatial expression browser! Full-resolution of H&E stained tissue sections and the gene expression from them. Great for seeing neuromelanin. (One sample = one tissue section).
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Bernie Mulvey @berniejmulvey.bsky.social · 31/10/2025
Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8) www.biorxiv.org/content/10.1...
biorxiv.org
Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition...
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