Bernie Mulvey @berniejmulvey.bsky.social · 01/10/2026Impromptu field research lunch yesterday turned up a looooooooonnngggg kitten for adoption at Affogatto cat cafe 050
Bernie Mulvey @berniejmulvey.bsky.social · 17/09/2026Have some (a boatload) more LC! www.nature.com/articles/s41...nature.comTopographic structure and function of locus coeruleus noradrenaline neurons - NatureDorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o... 020
Bernie Mulvey @berniejmulvey.bsky.social · 11/09/2026Excited to share work with cryostat wizard @heenadivecha.bsky.social looking at gene expression in my favorite brain region (LC) in adult postmortem brain! (Long URL to spare the trouble of identifying cars, buses, beds in 5x5 pixel imgs). (1/x) link.springer.com/epdf/10.1007...link.springer.comMolecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability 22516
Bernie Mulvey @berniejmulvey.bsky.social · 10/09/2026Study the biology of sex hormones and sex differences, folks! (From this week's @bbrfoundation.bsky.social seminar by @clearlab.bsky.social ) 030
Reposted by Bernie MulveyKeri Martinowich @martinowk.bsky.social · 24/07/2026For #FluorescenceFriday - maybe not the prettiest ever, but scientifically just super cool - zoom in to see DBH transcripts 🔵, marking noradrenergic neurons in locus coeruleus of human 🧠... w/ unexpected boatload of CARTPT 🔴. Image/data credits @berniejmulvey.bsky.social @heenadivecha.bsky.social 2205
Bernie Mulvey @berniejmulvey.bsky.social · 03/04/2026Excited to share our spatial omics from hypothal. are out in Cell Rep--with more interactive data browsing coming soon w/ UCSC single-cell browser! @kr-maynard.bsky.social @kasperdhansen.bsky.social •Paper: www.cell.com/cell-reports... •UCSC (demo): cells-test.gi.ucsc.edu?ds=hypothala...cell.comSpatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamusThe ventromedial hypothalamus (VMH) and arcuate (ARC) nuclei of the hypothalamus play critical roles in regulating metabolism and behavior. Here, Mulvey et al. create a focused spatial transcriptomic ... 040
Reposted by Bernie MulveyLouise Huuki-Myers @lahuuki.bsky.social · 04/11/2025Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...doi.orgTranscriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of PsychiatryObjective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ... 12614
Reposted by Bernie MulveyThe Transmitter @thetransmitter.bsky.social · 16/10/2025A large study of developing brains reveals genetic and molecular differences between males and females. The findings may help explain why neurodevelopmental conditions, including autism, occur at different rates in boys and girls. By @giorgiag-sciwriter.bsky.social bit.ly/4q9BsVHbit.lyGene-activity map of developing brain reveals new clues about autism’s sex biasBoys and girls may be vulnerable to different genetic changes, which could help explain why the condition is more common in boys despite linked variants appearing more often in girls. 0165
Bernie Mulvey @berniejmulvey.bsky.social · 01/11/202510/8: Any time you see two tissue sections, the other was the preceding or subsequent 10µm of tissue cut from the same donor, because @heenadivecha.bsky.social is a beast! As is the link to the browser with all 85 tissue sections available: samuibrowser.com/from?url=dat...samuibrowser.comSamui 010
Bernie Mulvey @berniejmulvey.bsky.social · 01/11/20259/8: The high-res spatial expression browser! Full-resolution of H&E stained tissue sections and the gene expression from them. Great for seeing neuromelanin. (One sample = one tissue section). 010
Bernie Mulvey @berniejmulvey.bsky.social · 31/10/2025Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8) www.biorxiv.org/content/10.1...biorxiv.orgImpact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleusThe locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition... 23112