iiinova — where your digital self keeps evolving

Reposted by Michael Kelberman

Bernie Mulvey @berniejmulvey.bsky.social · 11/09/2026

Excited to share work with cryostat wizard @heenadivecha.bsky.social looking at gene expression in my favorite brain region (LC) in adult postmortem brain! (Long URL to spare the trouble of identifying cars, buses, beds in 5x5 pixel imgs). (1/x) link.springer.com/epdf/10.1007...

link.springer.com

Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability

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Reposted by Michael Kelberman

davidweinshenker.bsky.social @davidweinshenker.bsky.social · 08/09/2026

Pleased to share a new Addiction Neuroscience Special Issue "Early Life Influences on Addiction" edited by @madrelabutd.bsky.social with contributions from @ericagrodin.bsky.social, @laurenmac.bsky.social, Marvin Diaz, Elizabeth Byrnes, and Chris Pierce! www.sciencedirect.com/special-issu...

sciencedirect.com

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Reposted by Michael Kelberman

davidweinshenker.bsky.social @davidweinshenker.bsky.social · 10/08/2026

Pleased to share a new Addiction Neuroscience Special Issue "The ventral pallidum as an orchestrator of reward seeking behavior" edited by Meaghan Creed with contributions from her, Anushree Karkhanis, @bensaunders.bsky.social, Asheeta Prasad, and Yvan Vachez www.sciencedirect.com/special-issu...

sciencedirect.com

Addiction Neuroscience | The ventral pallidum as an orchestrator of reward seeking behavior | ScienceDirect.com by Elsevier

Read the latest articles of Addiction Neuroscience at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

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Michael Kelberman @mikekelberman.bsky.social · 31/07/2026

Incredibly grateful to have been selected by the @simonsfoundation.org as a recipient of the 2026 SCPAB Fellows-to-Faculty award! A special thanks to @neurozoe.bsky.social and the rest of my mentors for their incredible support up to this point in my career.

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Reposted by Michael Kelberman

Stephanie Staszko @sstaszko.bsky.social · 30/07/2026

Studying norepinephrine? Have cool results to share? Want to join an online community of norepinephrine researchers? We are organizing our fall schedule for the Blue Spot Slack! We have monthly virtual seminars where you can share your work and get feedback in a supportive environment. Apply/join ⬇️

Immunohistochemical staining showing noradrenergic neurons of the locus coeruleus

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Reposted by Michael Kelberman

Neuropsychopharmacology @npp-journal.bsky.social · 21/07/2026

Hot off the press, we're back with another roundup of #ThisWeekinNPP #TWiNPP 👇

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Michael Kelberman @mikekelberman.bsky.social · 15/07/2026

New hot topics piece in @npp-journal.bsky.social where @neurozoe.bsky.social and I argue for the importance of studying the role of social bonds (as opposed to just loneliness/isolation) in determining clinical trajectories during aging. www.nature.com/articles/s41...

nature.com

The role of spousal relationships in shaping clinical trajectories during aging - Neuropsychopharmacology

Neuropsychopharmacology - The role of spousal relationships in shaping clinical trajectories during aging

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Reposted by Michael Kelberman

davidweinshenker.bsky.social @davidweinshenker.bsky.social · 22/06/2026

Interested in how dysregulation of locus coeruleus-norepinephrine circuits contribute to neuropsychiatric symptoms in early Alzheimer's disease? Check out our new review article from freshly minted Dr. Anu Korukonda! www.nature.com/articles/s41...

nature.com

A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms - Molecular Psychiatry

Molecular Psychiatry - A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms

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Reposted by Michael Kelberman

Natale R. Sciolino, PhD @sciolinolab.bsky.social · 06/06/2026

1/ New preprint from our lab: “Locus coeruleus activation transforms cortical taste representations” We asked how a major neuromodulatory system reshapes cortical taste coding toward behaviorally meaningful features. www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Michael Kelberman

davidweinshenker.bsky.social @davidweinshenker.bsky.social · 02/02/2026

Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6... 1/3

biorxiv.org

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Reposted by Michael Kelberman

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 02/02/2026

Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease www.biorxiv.org/content/10.64898/20…

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Reposted by Michael Kelberman

Heidi Jacobs @heidijacobslab.bsky.social · 21/01/2026

The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...

alz.surveymonkey.com

Publication of the Year Award - Nomination

Thank you for submitting your Nomination!

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Michael Kelberman @mikekelberman.bsky.social · 09/01/2026

New paper from @neurozoe.bsky.social www.nature.com/articles/s41.... We uncover a role for nucleus accumbens calcium permeable AMPA receptors (CP-AMPARs) in pair bond formation. Congrats to first author Mostafa and all the other amazing co-authors!

nature.com

Client Challenge

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Reposted by Michael Kelberman

Lindsay Schwarz @lindsayschwarz.bsky.social · 15/12/2025

Thrilled this is out, led by former PD Cameron Ogg (now with her own lab at @rhodescollege.bsky.social!). It was a driven by a desire to see, in real-time, how LC activity/NE release influences downstream targets in behaving animals. SO hard to do, but Cameron did it! www.cell.com/cell-reports...

cell.com

Locus coeruleus norepinephrine neurons facilitate orbitofrontal cortex remapping and behavioral flexibility

Ogg et al. use in vivo imaging techniques to record activity in the locus coeruleus (LC) and the orbitofrontal cortex (OFC) during a reversal learning task in freely moving rodents. They show that man...

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Michael Kelberman @mikekelberman.bsky.social · 15/11/2025

New pre-print led by the talented undergrad Alexia with @davidweinshenker.bsky.social We used chronic DSP-4 treatment to lesion the LC-NE system in young TgF344-AD rats to see whether early degeneration led to accelerated onset of pathology and behavioral deficits. www.biorxiv.org/content/10.1...

biorxiv.org

Impact of early locus coeruleus lesions in the TgF344 Alzheimer’s disease rat model

INTRODUCTION In murine models of Alzheimer’s disease (AD), lesioning the locus coeruleus-norepinephrine (LC-NE) system with DSP-4 exacerbates AD-like neuropathology and cognitive impairment. However, ...

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Reposted by Michael Kelberman

davidweinshenker.bsky.social @davidweinshenker.bsky.social · 15/11/2025

At #SFN2025 and interersted in the 🔵? Check out posters from Leslie Hassanein (D52; neuromelanin in the mouse locus coeruleus) and Maggie Tish (C59; human 3D locus coeruleus organoids) today from 1:00-5:00!

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Michael Kelberman @mikekelberman.bsky.social · 01/04/2025

Abstract deadline extended for the Integrative Neuromodulatory Subcortical Systems 2025 meeting! Supported by @ISTAART and hosted by @NSS_PIA & @SleepPIA 🧠💤 Boston, MA USA or online | July 17-18 📅 Abstracts due 4/15 11:30pm EST ✅ Registration & more info: education.martinos.org/inss2025/

education.martinos.org

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Reposted by Michael Kelberman

Mary Kay Lobo @marykaylobo.bsky.social · 20/03/2025

Check out the amazing line up of speakers for the Catecholamines GRC! Apply for GRC www.grc.org/catecholamin... & GRS www.grc.org/catecholamin.... In these uncertain times we appreciate any donation to support the participants in the GRC my.grc.org/p/contributi... & GRS my.grc.org/p/contributi...

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Michael Kelberman @mikekelberman.bsky.social · 20/03/2025

For anyone studying catecholamines please consider applying for the GRC and GRS (trainees only!) Catecholamines being held in August of this year. I'll be coordinating the GRS portion of the meeting with Darshana, so please reach out with any questions.

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Reposted by Michael Kelberman

davidweinshenker.bsky.social @davidweinshenker.bsky.social · 13/01/2025

For LC researchers on BlueSpot Slack but haven't checked it, @mikekelberman.bsky.social and Ellen Rodberg will present their work on LC ephys tomorrow at 11 am EST. Link on General channel. If you are not on BlueSpot and want to attend, email me dweinsh@emory.edu. www.biorxiv.org/content/10.1...

biorxiv.org

Diversity of ancestral brainstem noradrenergic neurons across species and multiple biological factors

The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution has woven the LC into wide-ranging neural circuits that influence functions as broad as autonomi...

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Michael Kelberman @mikekelberman.bsky.social · 25/11/2024

Introducing myself on here! I'm a Post-Doc in Zoe Donaldson's lab at CU Boulder interested in using prairie voles to understand social deficits in Alzheimer's disease, with a side interest in the coolest brain region, the locus coeruleus 🔵. Check out two of my most recent publications below:

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