The B cell receptor (BCR) drives the differentiation of naive B cells into activated plasma cells that produce antibodies. The BCR consists of a plasma membrane-bound surface immunoglobulin (sIg) that...

The detailed study of membrane contact sites is challenging owing to their small size and highly dynamic nature. This Review highlights advanced imaging methods and available biosensors that can be us...

In humans, the CHC22 isoform of clathrin regulates glucose metabolism by trafficking the GLUT4 glucose transporter for intracellular storage in skeletal muscle and release following insulin signalling...

In cells, ESCRT-III is unique in mediating fission of membrane necks from inside, a process called reverse-topology fission. Yet, in vitro, the complex primarily assembles outside membrane necks and m...

Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics

(Cell Metabolism 37, 1–18.e1–e13; May 6, 2025)

Adipocyte dysfunction is a major driver of obesity-associated cardiometabolic disease, underscoring the need to understand how lipid storage and mobilization are regulated and disrupted. The ER-anchor...

The mitochondrial phosphatase PPTC7 is required to sustain mammalian metabolism, as its global knockout (KO) triggers hypoketotic hypoglycemia and perinatal lethality in mice. However, the extent to w...

The mechanisms coordinating the homeostasis of glucose, lactate, fatty acids, and ketones remain unknown. Through quantitative modeling and experiments, Weilandt et al. reveal that these nutrients compete to be oxidized to meet systemic energy demands. Competitive catabolism normally produces homeostasis but, in obesity, converts increased lipolytic propensity into hyperglycemia and hyperinsulinemia.

In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Speakers invités: Giovanni D’Angelo (EPFL, Lausanne, Suisse) Christophe Leterrier (INP, Marseille, France) Miriam Stoeber (University of Geneva, Genève, Suisse)

This Perspective discusses the mechanisms underlying both the formation and scission of caveolae, with a focus on highlighting the role of specific lipids in regulating and coupling these processes.

Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemical…

We have two exciting master thesis projects available in the lab. Please see the announcements below. Start date is flexible, but earliest September or October 2026. If you are interested, please send...

Using single-cell tissue imaging and spatial proteomics to study mitochondria–lipid droplet coupling in hepatocytes, PLIN5 phosphorylation is identified as a mediator of lipid flux and nutrient stress...

Read the latest chapters of Methods in Enzymology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...

Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...

Nature - Systematic analyses of lipid mobilization by human lipid transfer proteins

Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

Worcester et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study lipids.

Quitting projects in science is hard, but we should be doing a lot more of it.

Removal of SNO groups from hepatocyte and adipocyte proteins induces lipid synthesis and weight gain.