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Holthuis Lab

@holthuislab.bsky.social
370 followers 378 following 43 posts

Lipid cell biologists who love to hang out with chemists & computer simulations experts to grasp the complex behavior of membranes

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Giovanni D’Angelo @giodang.bsky.social · 23/09/2026
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Nature Cell Biology @natcellbio.nature.com · 21/09/2026
☕ @majarad.bsky.social et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit the ATPase DFCP1, which promotes lysosome repair. www.nature.com/articles/s41...
nature.com
DFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell Biology
Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...
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Robert Arkowitz @robertarkowitz.bsky.social · 19/09/2026
AI and authorship: Norms and uses to preserve human-led science academic.oup.com/pnasnexus/ar...
academic.oup.com
AI and authorship: Norms and uses to preserve human-led science
The use of AI in scientific authorship has moved from a speculative concern to a practical reality. Authors, reviewers, editors, publishers, and readers ar
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Holthuis Lab @holthuislab.bsky.social · 06/09/2026
Dear friends, take note of this position paper issued by the German Science Foundation on how to make the research ecosystem resilient against growing threats. Assuming this will blow over is a mistake. Academic freedom is an achievement of free, democratic societies that must be actively defended.
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Stand Up for Science! @standupforscience.net · 09/08/2026
Sign our petition in support for Dr. Fauci! : zurl.co/6tdkA Article: zurl.co/1zgnt
zurl.co
GOP senators vote to hold Anthony Fauci in contempt of Congress for invoking the Fifth during tense hearing
Fauci declined to answer senators’ questions over 100 times during last week’s hearing, angering Republican lawmakers who have targeted him for years.
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Stand Up for Science! @standupforscience.net · 09/08/2026
Stand Up for Science is excited to be expanding internationally to strengthen the global fight for evidence-based policy and support emerging pro-science movements and communities. Threats to science don’t stop at borders, and neither does our movement. Article: zurl.co/wlV0z
zurl.co
US Stand Up for Science movement expands to Europe
A grassroots movement by scientists in the US pushing back against threats to academic freedom is setting up a Swiss outpost to take the movement global. 
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André Nadler @nadlerlab.bsky.social · 29/07/2026
Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...
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Beate Sodeik @beatesodeiklab.bsky.social · 23/07/2026
From the major German Funding Agency, the DFG; content-wise independent from the Government. Run by the universities and the scientists! 👊🏼 @dfg.de
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André Nadler @nadlerlab.bsky.social · 24/07/2026
A new, rather unexpected glycolipid class. Very well done study. Given how they look structurally, I think it makes a lot of sense to test these lipids against a panel of GPCRs. Lipid biology keeps surprising me. I like that. www.biorxiv.org/content/10.6...
biorxiv.org
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Ben Williamson @benpatrickwill.bsky.social · 18/07/2026
The anatomy of an AI-supported academic article is becoming more apparent. I desk reviewed ~70 manuscripts this week for our journal. Reckon 20ish had significant AI assistance. On top of hundreds of others recently I'm starting to see patterns. Are other editors are seeing the same or similar? 1/
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Randi Weingarten 🖇️📚✊🇺🇸 @rweingarten.bsky.social · 11/07/2026
Yale isn't just deciding whether to settle one investigation. They're deciding whether to cave to the Trump administration's campaign to use civil rights to control higher education. Yale has the resources to stand up for academic freedom. I hope they do(1/2) www.insidehighered.com/news/governa...
insidehighered.com
Faculty and Students Demand Yale Not “Cave” to Trump
Reports surfaced late last month that Yale University is negotiating a deal with the Trump administration, which is investigating the university’s admissions practices.
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Holthuis Lab @holthuislab.bsky.social · 06/07/2026
Deeply shocking, these White House draft regulations regarding federal funded research in the US, primarily aimed at advancing the interests of one individual. Hope 🇺🇸 scientists will make some coherent noise to divert a disaster that will undermine science & innovation in the US and far beyond
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Holthuis Lab @holthuislab.bsky.social · 03/07/2026
📯Congratulations to Michael Timme, who defended his PhD thesis “Decoding the tumor suppressor activity of ceramides through molecular dynamics simulations” with flying colors today 🎩, leaving behind two proud (and somewhat tipsy) Doktorvaters 🥂 @melolab.bsky.social & @holthuislab.bsky.social
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Holthuis Lab @holthuislab.bsky.social · 02/07/2026
📯 Our paper “VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair” out now in Nature Communications rdcu.be/frKmN
rdcu.be
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Nature Communications - Not all components of the lysosome damage response pathway have been defined. Here, the authors discover that the bridge-like lipid transport protein VPS13C senses lysosomal...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 27/06/2026
Truly bizarre story of how two papers from the 1940s by physics pioneer Max Planck have been "retracted" from Naturwissenschaften, potentially by an algorithm, for anachronistic "plagiarism" issues, leaving the current editor baffled (but it is Springer Nature so.... www.science.org/content/arti...
science.org
Why have papers by one of history’s most famous physicists been retracted?
Springer Nature has removed two studies by Max Planck. A bot may be to blame
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Birol Cabukusta @birolcabukusta.bsky.social · 25/03/2026
Check out my interview at @maastrichtu.bsky.social www.maastrichtuniversity.nl/news/researc...
maastrichtuniversity.nl
Research into the silent dynamics of cells
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Holthuis Lab @holthuislab.bsky.social · 20/05/2026
If you are looking for a cool PhD project on lysosome biogenesis under supervision of an excellent mentor in a thriving research community, this is your chance ungermannlab.bsky.social👇
ungermannlab.xn--bs-vl72a
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Iris van Rooij 💭 @irisvanrooij.bsky.social · 19/04/2026
Advice for @erc.europa.eu : Prohibit the use of LLMs for grant writing. Let applicants sign a declaration that they have not used such systems and that the text is written by them and them alone.
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Holthuis Lab @holthuislab.bsky.social · 20/05/2026
If you are looking for a cool PhD project on lysosome biogenesis under supervision of an excellent mentor in a thriving research community, this is your chance ungermannlab.bsky.social👇
ungermannlab.xn--bs-vl72a
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Iris van Rooij 💭 @irisvanrooij.bsky.social · 13/05/2026
“We must protect and cultivate the ecosystem of human knowledge. AI models can mimic the appearance of scholarly work, but they are (by construction) unconcerned with truth — the result is a torrential outpouring of unchecked but convincing-sounding “information”. — as quoted in Guest et al. (2026)
digitalcultureandeducation.com
Against the Uncritical Adoption of ‘AI’ Technologies in Academia — Digital Culture & Education (ISSN: 1836-8301)
Written by: Olivia Guest, Marcela Suarez, Barbara C. N. Müller, Edwin van Meerkerk, Arnoud Oude Groote Beverborg, Ronald de Haan, Andrea Reyes Elizondo, Mark Blokpoel, Natalia Scharfenberg, Annelies ...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 13/05/2026
While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪
https://www.nature.com/articles/s41586-025-10004-2
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

    U. Sahin, M. Schmidt, E. Derhovanessian, A. Cortini, I. Vogler, T. Omokoko, E. Godehardt, S. Attig, S. Newrzela, J. Grützner, N. Bidmon, S. Bolte, S. Brachtendorf, T. Stuhlmann, D. Langer, D. Brüne, J. Blake, A. Feldner, H. Lindman, A. Schneeweiss, M. Eichbaum & Ö. Türeci 
Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. Here we assessed an individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy. In peripheral blood of nearly all patients, high-magnitude, vaccine-induced, mostly de novo T cell responses to multiple neoantigens were detected that remained functional for several years. Characterization of individual patients revealed that a large proportion of these T cells developed into two subsets: a late-differentiated phenotype with markers indicative of ‘ready-to-act’ cytotoxic effector T cells, and T cells with a stem cell-like memory phenotype. Eleven patients remained relapse-free for up to six years post-vaccination. Recurrence occurred in three patients: the individual with the weakest vaccine-induced T cell response relapsed, but achieved complete remission on subsequent anti-PD-1 therapy; another patient had a tumour with low major histocompatibility complex (MHC) class I expression with MHC class I-deficient cells growing out under vaccination; and the third patient was BRCA-positive and had a recurrence from a genetically distinct primary tumour. These findings demonstrate the feasibility of individualized RNA vaccines in TNBC, document persistence of vaccine-induced, functional neoantigen-specific T cells and provide insights into possible immune escape mechanisms that will guide future approaches.
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Holthuis Lab @holthuislab.bsky.social · 29/04/2026
📯Proud to share a preprint of a joint paper with Michael Timme and @melolab.bsky.social on how ceramides disrupt hexokinase binding to VDACs and modulate channel tilting. Our CG-MD simulations reveal a potential mechanism by which ceramides may induce apoptotic cell death📯 bsky.app/profile/bior...
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Kristian G. Andersen @kgandersen.bsky.social · 10/04/2026
Choice words from Dr. Szostak here. And while I am no Nobel Prize-winning scientist, I identify with the same quandary as an immigrant, moving here in 2009 and (proudly) becoming a citizen in 2023. I, too, don't recognize that country anymore 😢🇺🇸🧳🛫. newsletter.ofthebrave.org/p/im-a-nobel...
newsletter.ofthebrave.org
I’m a Nobel Prize-winning immigrant. I can no longer recognize this country.
Attacks on science and immigrants are destroying America.
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Bella Rauch @rauchlab.bsky.social · 28/04/2026
Wan’t to be faculty at a collegial host-pathogen focused department in a beautiful bikable city with amazing food? This link is for you: facultycareers-ohsu.icims.com/jobs/39006/a...
A picture of the portland waterfront during cherry blossom time
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Nature Cell Biology @natcellbio.nature.com · 13/04/2026
☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains. bit.ly/4moYLJH
bit.ly
Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology
Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...
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GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 27/03/2026
The 2026 Otto Warburg Medal winner Maya Schuldiner received the medal from @volkerhaucke-lab.bsky.social after a moving laudatio by Christian Ungermann Thanks to @elsevierconnect.bsky.social for the continuous support!
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Patrick van der Wel @pcavanderwel.bsky.social · 25/03/2026
Looks like a great @embo.org workshop coming in September: “Lipid Code to Life”, with a who’s who of lipid #biochemistry… (e.g. @dimovalab.bsky.social @holthuislab.bsky.social @sciezgin.bsky.social etc ) More info and registration: meetings.embo.org/event/26-lip... #lipids #biophysics
meetings.embo.org
Lipid Code to Life
Modern lipid biology has evolved far beyond the traditional view of lipids as simple building blocks or energy substrates. Lipids are now recognised as dynamic regulators of biological structures and…
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Phil Holliger @philholliger.bsky.social · 13/02/2026
New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/... Outstanding work by @edogia.bsky.social
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 13/02/2026
How did life arise from simple chemical building blocks? New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer. Read more: mrclmb.ac.uk/news-events/...
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Holthuis Lab @holthuislab.bsky.social · 12/02/2026
📯Congratulations to Tobi Adeosun, who defended his PhD thesis on “transbilayer lipid dynamics & inter-organellar lipid transfer in lysosomal repair” with flying colors today 🎩 and joined Saron Tooze’s lab at the Crick Institute, leaving behind a proud and tipsy Doktorvater 🥂
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Holthuis Lab @holthuislab.bsky.social · 18/01/2026
Modern lipid biology has grown far beyond its roots. Advanced technologies offer novel opportunities to unravel the role of lipids in the organization of biological systems. Build on this momentum and join The EMBO Workshop "The Lipid Code to Life" Sept 7-11, 2026 meetings.embo.org/event/26-lip...
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GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 05/01/2026
Have you registered yet? Early bird registration and abstract submission are open until January 31. mosbacher-kolloquium.org
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André Nadler @nadlerlab.bsky.social · 17/01/2026
Do register! It is really worth it, I promise!
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Coskun Lipid Cellar @ ZML Dresden @lipid.bsky.social · 15/12/2025
Please sign up on coming-soon.embo.org/w26-51 to be informed once the website is live. We are very very very much looking forward to welcoming you to Dresden, one of the most lipid-loving cities, next year!
coming-soon.embo.org
The lipid code to life
7–11 September 2026 | Dresden, Germany
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Coskun Lipid Cellar @ ZML Dresden @lipid.bsky.social · 15/12/2025
Ups we did it again! Please mark your calender. EMBO Workshop “Lipid Code to Life”, taking place September 7–11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social 🥳 Retweets = lipidlove
copyright Palina Nepachalovich of ZML Dresden
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bioRxivpreprint @biorxivpreprint.bsky.social · 05/11/2025
Key determinants of VDAC-hexokinase I complex assembly revealed by a minimal vesicle-based interaction assay www.biorxiv.org/content/10.1101/202…
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Tanmay Bharat @tbharat-lab.bsky.social · 07/11/2025
An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...
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Holthuis Lab @holthuislab.bsky.social · 27/10/2025
Such a worthy recipient. Maya is not only a great scientist but also a fantastic mentor and a rich source of inspiration.
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Holthuis Lab @holthuislab.bsky.social · 26/10/2025
📯 shoutout for this beautiful work by Kenji Maeda’s lab, who mapped 300 lipid species across 6 compartiments of humane cells. Besides uncovering general principles of lipid organization, the paper establishes a framework for exploring how lipid landscapes are regulated in physiology and disease 👇🏼
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Holthuis Lab @holthuislab.bsky.social · 25/10/2025
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
biorxiv.org
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
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Holthuis Lab @holthuislab.bsky.social · 17/10/2025
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
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Holthuis Lab @holthuislab.bsky.social · 17/10/2025
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
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Holthuis Lab @holthuislab.bsky.social · 14/10/2025
I am proud to 📣 today’s superb thesis defense by Milena Wessing on “Molecular dissection of ceramide-induced apoptosis: a bottom-up approach”. Two papers describing Milena’s heroic efforts are close to submission. It was a privilege serving as her “Doktorvater” 🥂
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Holthuis Lab @holthuislab.bsky.social · 30/09/2025
I am pleased to 📣 today’s superb thesis defense by Christian Schroer on “Chemical strategies for studying lipid signaling and transport”. Part of his work was recently published in the JLR; the other part will follow soon. A very proud and somewhat tipsy “Doktorvater” 🥂
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Holthuis Lab @holthuislab.bsky.social · 31/08/2025
Great to see this work on imaging cellular lipid logistics in Nature, where it belongs. Chapeau! Many gratulations to Andre, Alf and their co-workers!
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Holthuis Lab @holthuislab.bsky.social · 05/07/2025
🔥🔥🔥 (= highly recommended) 👇🏼
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Holthuis Lab @holthuislab.bsky.social · 27/06/2025
A university & its leadership standing for academic freedom, truth, integrity & shared values deserve support from across the globe. Those believing in these virtues greatly outnumber those who seek to undermine them. As admirer of the 1st class scientists working at UVA, I gladly signed the letter👇
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Holthuis Lab @holthuislab.bsky.social · 07/06/2025
Science is the engine of an open, pluralistic society. So scientists serve a central role in defending it. In 🇩🇪, the association „Wissenschaft für Demokratie – Wir für Dich“ was founded to strengthen the role of science in the public debate & in the fight against disinformation wirfuerdemokratie.org
wirfuerdemokratie.org
Wir für Demokratie | Unabhängig & Überparteilich
Demokratisches Engagement Für Dich. Für mich. Für uns alle. Wir sind ein gemeinnütziger Verein, der einen niedrigschwelligen Zugang zu demokratischer Beteiligung ermöglicht. Als Plattform für überpart...
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Holthuis Lab @holthuislab.bsky.social · 16/05/2025
Thank you so much @jamessaenz.bsky.social‬ for the inspiring #sfb1557 talk on lipid-sensitive riboswitches and the role of lipid diversity & membrane biophysics in the origin of life. A great scientist & wonderful colleague to hang out with 🍺, who is currently on the job market, but not for long… 🚴‍♂️
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KNAW - Koninklijke Nederlandse Akademie van Wetenschappen @knaw-nl.bsky.social · 15/05/2025
Academische vrijheid staat onder druk en moet beter worden beschermd. Die conclusie lees je vandaag in dit KNAW-rapport: www.knaw.nl/nieuws/knaw-... Aanbevelingen o.m.: meer vrijheid van onderzoek, bescherming tegen intimidatie en minder inhoudelijke overheidsbemoeienis.
Rapport KNAW: Academische vrijheid in Nederland
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