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Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.

The transcription factor p53 enables phosphoethanolamine scavenging to support increased membrane phospholipid synthesis during senescence. Perturbing lipid synthesis or recycling compromises the fitn...

Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and in...

M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.

Nature Metabolism, Published online: 28 April 2025; doi:10.1038/s42255-025-01289-8Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

April 8, 2025 | 9:00 AM – 5:00 PM ET Join leading experts at the forefront of cancer metabolism research for a one-day event on April 8, 2025, in New York City. The New York Academy of Sciences invite...

A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.

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Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.

Hyperactive WNT signaling is a potent cancer driver, but clinical translation of WNT inhibitors has been hampered on-target toxicities. WNT signaling can be constrained through inhibition of the PARP ...

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Abstract. Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to...

Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

Join us at the Keystone Symposia on Metabolic and Nutritional Control of Development and Cell Fate, May 2025, in Beverly, with field leaders!

Join us at the Keystone Symposia on Metabolic and Nutritional Control of Development and Cell Fate, May 2025, in Beverly, with field leaders!

Mitochondrial respiratory chain (RC) activity is essential for in vivo cell proliferation, particularly in cancer, CD4+ and CD8+ T cells, and endothelial cells involving ATP production and biosynthesi...