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Gerlich Lab

@gerlichlab.bsky.social
433 followers 77 following 63 posts

We study how genomes change shape to make biology work through genomics, imaging, reconstitution, & computation. Lab website: oeaw.ac.at/imba/research/daniel-gerlich Located at @imbavienna.bsky.social, part of @viennabiocenter.bsky.social

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Gerlich Lab @gerlichlab.bsky.social · 23/09/2026
Neos @neoscruz.bsky.social is on a roll! Last week, he gave his second Monday Seminar, presenting his PhD research to the @viennabiocenter.bsky.social community. Another big milestone in his PhD. Good job, Neos! 👏🧬
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Gerlich Lab @gerlichlab.bsky.social · 13/09/2026
Congratulations to Neos @neoscruz.bsky.social on placing 3rd last week at Falling Walls Lab Vienna 2026! 🎉 In his pitch, “Breaking the Wall of RNA’s Hidden Shape,” he showed how his PhD work lets us visualize the shapes of individual mRNA molecules inside cells.
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Gerlich Lab @gerlichlab.bsky.social · 11/09/2026
Last week, we said goodbye to Enzo @enzozenner.bsky.social and William @williamle2585.bsky.social 👋 . Enzo joined us for a few months to work on his Master’s thesis, while William joined us through the Vienna BioCenter Summer School. It was great having you, and all the best to you both! ✨
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Gerlich Lab @gerlichlab.bsky.social · 11/09/2026
Congratulations @golobor.bsky.social and the whole team! Always great collaborating on some very cool science 🧬👏
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Reposted by Gerlich Lab
Anton Goloborodko @golobor.bsky.social · 03/09/2026
Thomas Steinacker from @gerlichlab.bsky.social found a way to verify this using optical microscopy and RASER-FISH. He developed strand-specific probes and hybridized them to individual sisters, thus measuring distances between sister loci and visualizing the shift. 8/
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Gerlich Lab @gerlichlab.bsky.social · 21/08/2026
Our paper is out in The EMBO Journal @embojournal.org! 🎉 We show how replicated chromosomes can maintain sister chromatid cohesion while still allowing dynamic loop folding within nested hierarchy of TADs. Check it out below 👇 1/2
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Gerlich Lab @gerlichlab.bsky.social · 06/08/2026
That’s a wrap on this year’s Chromatin Consortium in Woods Hole! 🧬 The @danielgerlich.bsky.social , @rcollepardo.bsky.social , @vram142.bsky.social, Gibson, and Rosen labs came together to exchange ideas, run experiments, and explore chromatin organisation from different angles. 1/4
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Gerlich Lab @gerlichlab.bsky.social · 15/07/2026
Last month’s Lab Retreat at Gustav Ammerer’s castle 🏰🌿 Hiking, cooking together, personality tests, TED-style talks, and a very intense round of Blood on the Clocktower. A lovely few days of science, reflection, games, food, and getting to know the lab beyond work and the bench.
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Gerlich Lab @gerlichlab.bsky.social · 11/06/2026
Congratulations again, Max! 🎉 We’re so proud of you and grateful to have had you in the lab. Wishing you all the best for the exciting next chapter! 👏
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Gerlich Lab @gerlichlab.bsky.social · 09/06/2026
The Gerlich lab recently attended the International Symposium on Chromosome Dynamics: from Structure to Cellular Function in Awaji, Japan 🇯🇵 A really nice chance to share our work, exchange ideas, and catch up with the chromosome dynamics community. 1/3
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Gerlich Lab @gerlichlab.bsky.social · 29/05/2026
Congratulations to Max @mfdspicer.bsky.social on completing his PhD! 🎉 Yesterday, he successfully defended his thesis, “Electrostatic control of apoptotic chromatin compaction.” The lab is very proud of you, Max! 👏 1/2
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Gerlich Lab @gerlichlab.bsky.social · 07/05/2026
Welcome to the Gerlich Lab, Valerio! 🎉 We’re excited to have you on board and look forward to the great science ahead together. 🧬
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Gerlich Lab @gerlichlab.bsky.social · 06/05/2026
New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗 doi.org/10.64898/2026.05.02.722390 1/6
doi.org
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Gerlich Lab @gerlichlab.bsky.social · 27/04/2026
Congratulations to Caelan on completing their PhD! 🎉 Last week, they defended their thesis, “Unravelling the Surface Localisation of Centromeres on Vertebrate Chromosomes in Mitosis.” The lab is very proud of you, Caelan! 👏 1/2
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Gerlich Lab @gerlichlab.bsky.social · 20/04/2026
Last week, the Gerlich lab went to Prein an der Rax for a writing retreat, or as we liked to call it, a “storython” ✍️🏔️ Led by Iain Patten, it was a chance to step away from day-to-day experiments and focus on building clearer, more coherent stories around our research. 1/4
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Gerlich Lab @gerlichlab.bsky.social · 25/02/2026
1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰ Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs: www.biorxiv.org/content/10.6...
biorxiv.org
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 05/12/2025
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great for those interested in graduate study in the life sciences. Daniel Gerlich from Institute of Molecular Biotechnology is recruiting! Please share training.vbc.ac.at/summer-school
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Gerlich Lab @gerlichlab.bsky.social · 05/12/2025
Excited to share our latest fully in-house paper! 🎉 We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair. Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏 We’re excited to see his next steps!
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Institute of Molecular Biotechnology @imbavienna.bsky.social · 04/12/2025
🚨 New Science paper from the Gerlich lab! The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
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Gerlich Lab @gerlichlab.bsky.social · 11/11/2025
Huge congratulations to @mfdspicer.bsky.social, PhD student in our lab, for winning the Best Poster Prize at the 2nd Spatial Genome Organization Conference! 🎉 A proud moment for the lab and well-deserved recognition for his creativity and dedication. 👏 @fusionconf.bsky.social #SGO25
“Maximilian Spicer holding the Best Poster Prize certificate at the 2nd Spatial Genome Organization Conference.”
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Gerlich Lab @gerlichlab.bsky.social · 03/09/2025
1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...
doi.org
An electrostatic repulsion model of centromere organisation
During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...
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Gerlich Lab @gerlichlab.bsky.social · 12/02/2025
Our lab is now on Bluesky! 🚀 Kicking things off by sharing @fedeteloni.bsky.social latest preprint on the role of cohesin in homology search. Check out the thread for more details!
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