Sign in

Doris Kaltenecker

@dorie00.bsky.social
177 followers 178 following 20 posts

Postdoc @Helmholtz Munich. Working in Cancer, #Metabolism, Transcription, Tissue Clearing & #Light-sheet Imaging 🔬

PostsRepliesMedia
Reposted by Doris Kaltenecker
Anna Obenauf @obenaufa.bsky.social · 21/09/2026
We are so excited to have @dorie00.bsky.social Doris Kaltenecker join the @impvienna.bsky.social soon. Doris is using cutting edge technologies to study cancer cachexia. I can highly recommend joining a junior lab and can't wait to have her around!
1155
Doris Kaltenecker @dorie00.bsky.social · 21/09/2026
💫 Thrilled to share that I’ll join the IMP in Vienna as a Group Leader in March 2027! My lab will study systemic disease across biological scales, from molecular mechanisms to organism-wide dynamics, with a focus on cancer cachexia. www.imp.ac.at/groups/doris...
1162
Reposted by Doris Kaltenecker
Sasha | Kai Dao 🔬 @kaidaoscience.bsky.social · 21/08/2026
What happens when you make an organism transparent & use AI to map every cell? 🔬 An incredible @nature.com paper by @dorie00.bsky.social & @erturklab.bsky.social mapped metabolic stress—revealing damage far beyond the usual suspects. Watch: youtu.be/RfNoEu9_VJ8 #FluorescenceFriday #Microscopy
1187
Reposted by Doris Kaltenecker
Philip Ruthig @philipruthig.bsky.social · 04/08/2026
Got your own (mouse brain-) 3D data from clearing and light sheet imaging, but no idea how to tackle the analysis? We have just the solution for you in Munich: A two-day course on deep learning and VR-assisted segmentation, atlas registration, and so on! Take the course at @erturklab.bsky.social
151
Reposted by Doris Kaltenecker
Nature @nature.com · 22/05/2026
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level go.nature.com/3Pjox61
go.nature.com
A deep-learning framework reveals whole-body perturbations at cell level - Nature
An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.
05218
Reposted by Doris Kaltenecker
Hao Yin @haoyin.bsky.social · 05/06/2026
MouseMapper An imaging-omics workflow of whole-mouse analysis Up to single-cell resolution!👹 vDISCO WildDISCO whole-mouse optical clearing #SpatialProteomics Trigeminal ganglia VR annotation of major organs, peripheral nerve & Mφ @erturklab.bsky.social Nature 2026 www.nature.com/articles/s41...
0248
Reposted by Doris Kaltenecker
Ali Maximilian Erturk @erturklab.bsky.social · 28/05/2026
Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. Paper->> www.nature.com/articles/s41... Next www.biorxiv.org/content/10.6...
02210
Doris Kaltenecker @dorie00.bsky.social · 25/05/2026
Super happy to see our work published in @nature.com last week 🤩 By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution. www.nature.com/articles/s41... @erturklab.bsky.social
2236
Reposted by Doris Kaltenecker
Danielle Beckman @daniellebeckman.bsky.social · 20/05/2026
Beautiful work published by my new Lab at @nature.com today! @dorie00.bsky.social et al. created MouseMapper, an AI-powered tool that identifies & maps cells/tissues throughout the whole mouse body. We can now use this for different diseases, such as #LongCovid. This is AI being used the right way!
511933
Reposted by Doris Kaltenecker
Waggoner Lab @labwaggoner.bsky.social · 20/05/2026
A deep-learning framework reveals whole-body perturbations at cell level @nature.com @erturklab.bsky.social @dorie00.bsky.social www.nature.com/articles/s41...
0154
Reposted by Doris Kaltenecker
Ali Maximilian Erturk @erturklab.bsky.social · 15/05/2026
🧠 Does brain aging always mean vessel loss? We found the opposite in some aged brains: maladaptive hypervascularization, linked to cognitive decline and blood-brain barrier damage. Check it out below! www.biorxiv.org/content/10.6...
0188
Reposted by Doris Kaltenecker
Nature Metabolism @natmetabolism.nature.com · 24/02/2026
RESEARCH @morignypauline.bsky.social @ondrej-kuda.bsky.social M Rohm (CAS, Helmholtz Munich) Multi-omics profiling of cancer cachexia models uncovers a multi-tissue coordinated response🧪
dlvr.it
Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer - Nature Metabolism
Multi-omics profiling of diverse cancer cachexia models uncovers a multi-tissue metabolite-coordinated response associated with disease progression and links multi-tissue one-carbon metabolism to wasting.
0107
Reposted by Doris Kaltenecker
Nature Metabolism @natmetabolism.nature.com · 15/01/2026
dlvr.it
Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer
Nature Metabolism, Published online: 15 January 2026; doi:10.1038/s42255-025-01434-3Multi-omics profiling of diverse cancer cachexia models uncovers a multi-tissue metabolite-coordinated response associated with disease progression and links multi-tissue one-carbon metabolism to wasting.
073
Doris Kaltenecker @dorie00.bsky.social · 19/12/2025
Such a great study, combining tissue clearing, imaging and scRNA-Seq 👏🏼
021
Reposted by Doris Kaltenecker
European Association for the Study of Diabetes @easdnews.bsky.social · 13/11/2025
Congrats to the 2025 #EFSD/@novonordisk.bsky.social A/S Programme for #DiabetesResearch in 🇪🇺 #grant recipients!🏆👏 Driving innovation across 🇪🇺 to advance knowledge & treatments for #diabetes. Excited to see the impact of your research 👉 www.europeandiabetesfoundation.org/recipients/e... #Funding
A graphic announcing the 2025 grant recipients of the EFSD/Novo Nordisk A/S Programme for Diabetes Research in Europe. The top of the image has a white text box with the program title in bold navy-blue letters. Below, “2025 Grant Recipients” is centred in white text on a green and teal geometric background. The recipients’ names, affiliations, and countries are listed in two rows:
Top row: Hannele Yki-Järvinen, University of Helsinki, Finland, Maike Sander, Max Delbrück Center for Molecular Medicine, Germany, Amandine Gautier-Stein, University of Lyon, France
Bottom row: Doris Kaltenecker, Helmholtz Munich, Germany, José Javier Fuster-Ortuño, National Center for Cardiovascular Research, Spain, Inga Prokopenko, University of Surrey, United Kingdom
The EFSD logo appears in the bottom left corner, and the website “europeandiabetesfoundation.org” is shown at the bottom right on a light blue band. The design features overlapping blue and green shapes with circular accents in the top right
052
Reposted by Doris Kaltenecker
Ali Maximilian Erturk @erturklab.bsky.social · 04/11/2025
We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...
11210
Reposted by Doris Kaltenecker
Philip Ruthig @philipruthig.bsky.social · 21/08/2025
How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are? In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️ plos.io/4mq5tOy #neuroscience #neuroskyence #whitematter #deeplearning
32213
Doris Kaltenecker @dorie00.bsky.social · 23/07/2025
Excited to share that our study on the role of the liver in #CancerCachexia is out in Cell! 😀 🧬 We found that the liver plays an active role in driving weight loss in cancer through disruption of the circadian regulator REV-ERBα and secretion of catabolic hepatokines www.cell.com/cell/fulltex...
3215
Reposted by Doris Kaltenecker
Helmholtz Munich @helmholtzmunich.bsky.social · 21/07/2025
🔬 New study: The #liver plays an active role in cancer #cachexia via silenced clock gene REV-ERBα. Key step toward new therapies. 👉 Read more: t1p.de/eh136 @tum.de @diabresearch-dzd.bsky.social @dorie00.bsky.social ky.social #CancerResearch #Cachexia #Liver
Researchers have identified a previously overlooked driver of cachexia: the liver.
064
Reposted by Doris Kaltenecker
Kepecs Lab @ WashU @kepecslab.bsky.social · 11/04/2025
1/ Why do patients with late-stage cancer lose motivation & sink into apathy? 🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵 🔗 doi.org/10.1126/scie...
doi.org
A neuroimmune circuit mediates cancer cachexia-associated apathy
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...
410045
Reposted by Doris Kaltenecker
Ali Maximilian Erturk @erturklab.bsky.social · 30/01/2025
See our recent @naturebiotech.bsky.social study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 www.nature.com/articles/s41...
03011
Reposted by Doris Kaltenecker
Philip Ruthig @philipruthig.bsky.social · 20/01/2025
As of today, the main finding of my PhD is published in the European Journal for Neuroscience! 🥳🥳 Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn.... 🧵
doi.org
Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex
We find that the right and left auditory cortex in mice are both organised in cortical columns, with asymmetric myelination in the different layers and differences between the sexes. In addition, the...
3199
Reposted by Doris Kaltenecker
Ali Maximilian Erturk @erturklab.bsky.social · 14/01/2025
Twitter: LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
2207
Reposted by Doris Kaltenecker
Martina Schweiger @schweigerlab.bsky.social · 11/01/2025
I am looking for a #PhD working on this exciting project! In case you are interested in how #immunometabolism and #macrophages affect #adipose tissue function, check the link below and apply! www.immunometabolism.at/job-openings/
immunometabolism.at
CALL for doctoral and postdoctoral researchers to join the special research program “Immunometabolism”
Three Austrian Universities located in Vienna and Graz combine forces to explore the immunometabolic interaction of macrophages with tissues. We are looking for 6 PhD and 6 postdoctoral researchers jo...
097
Doris Kaltenecker @dorie00.bsky.social · 05/12/2024
How does obesity reshape peripheral nerves and immune cells at the whole-body level? 🌟 Our preprint explores this using an AI-driven pipeline to precisely identify, map, and quantify these changes. Thrilled to share it with you here on BlueSky! 🦋😀 www.biorxiv.org/content/10.1...
biorxiv.org
0167
Reposted by Doris Kaltenecker
Ali Maximilian Erturk @erturklab.bsky.social · 29/11/2024
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇 @cellpress.bsky.social cell.com/cell-host-mi...
56736375
Reposted by Doris Kaltenecker
Eric Topol @erictopol.bsky.social · 29/11/2024
The SARS-CoV-2 spike protein can persist in the brain—in the skull bone marrow and meninges—to induce neurologic damage www.cell.com/cell-host-mi... open-access
40842335
Reposted by Doris Kaltenecker
Per Uhlén @peruhlen.bsky.social · 22/11/2024
Thrilled to announce that our latest work has been published in Science and featured on the front cover! www.linkedin.com/posts/scienc...
linkedin.com
Science Magazine on LinkedIn: This light-sheet microscopy three-dimensional rendering shows a…
This light-sheet microscopy three-dimensional rendering shows a first-of-its-kind mouse whole-brain mRNA analysis at single-cell resolution. Learn more in…
45312
Reposted by Doris Kaltenecker
Ali Maximilian Erturk @erturklab.bsky.social · 21/11/2024
Hey Bluesky! As Erturklab, we are also moving to alternative social media 😉. Stay in touch to follow our work on AI and tissue clearing driven cell-level imaging of intact mouse bodies and human organs, and how we use these methods to study diseases and develop therapeutics at the cellular level.
912330
Reposted by Doris Kaltenecker
Markus Elsner @markuselsner.bsky.social · 21/11/2024
And our lab is here, too, now. @erturklab.bsky.social Stay tuned ...
bsky.app
0113
Reposted by Doris Kaltenecker
Richard Sever @richardsever.bsky.social · 28/09/2023
bioRxiv goes big on Bluesky: accounts for all subject categories now available (Please Reskeet) connect.biorxiv.org/news/2023/09...
9285308
Doris Kaltenecker @dorie00.bsky.social · 04/10/2023
Hello Bluesky 🙋🏼‍♀️
130