Sign in

Kashish Singh

@kashishsingh.bsky.social
180 followers 234 following 5 posts

Postdoc @Carter_Lab @MRC_LMB. Alumnus of the Stark lab @mpi_nat.

PostsRepliesMedia
Reposted by Kashish Singh
Simon Bullock @simonbullock11.bsky.social · 28/09/2026
How are mRNAs linked to molecular motors in mammalian cells? In our new preprint, we show that FXR1/2 are RNA adaptors for the microtubule motor dynein. Our findings have also prompted us to rethink how activating adaptors contribute to motor-based transport (1/n)
16632
Reposted by Kashish Singh
Sami Chaaban @sami-c.bsky.social · 10/09/2026
Excited to share that the Chaaban Lab will be opening in January at the Crick!
77514
Reposted by Kashish Singh
Tanmay Bharat @tbharat-lab.bsky.social · 23/08/2026
Molecular architecture of colossal surface layers from hyperthermophilic archaea Led by @idocaspy.bsky.social (Ido) In collaboration with @mkrupovic.bsky.social and @vikramalva.bsky.social labs doi.org/10.64898/202...
215450
Kashish Singh @kashishsingh.bsky.social · 13/08/2026
Very happy to see the final version of our work on the structure and composition of cytoplasmic lattices in mouse embryos, previously shared on bioRxiv, now published in The EMBO Journal! Many thanks to our editor, Ieva Gailite, and the reviewers for their constructive input.
15019
Reposted by Kashish Singh
Wieczorek Lab @mike-wieczorek.bsky.social · 05/08/2026
New preprint! In collaboration with the Yogev lab (Yale), we characterized and determined structures of various gamma-tubulin complexes from C. elegans, showing how divergent worm subunits evolved to template non-canonical (11-pf) and possibly canonical (13-pf!) microtubules: tinyurl.com/2sapyx2b
02910
Reposted by Kashish Singh
Tanmay Bharat @tbharat-lab.bsky.social · 15/07/2026
Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA led by @olivia--smith.bsky.social Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs
28535
Reposted by Kashish Singh
University of Cambridge @cam.ac.uk · 26/06/2026
Scientists at Cambridge's @loke-ctr.bsky.social have, for the first time, used base editing to study gene function in human embryos. In future, the findings could help to improve IVF success rates and better understand early pregnancy loss. Read more: bit.ly/4aQOAZD
A digitally enhanced image showing colorful cellular structures in shades of purple, pink, teal, and yellow on a black background, accompanied by the text: "New Cambridge research: First use of precision editing to study human embryo development reveals role of master gene."
1115
Reposted by Kashish Singh
Wieczorek Lab @mike-wieczorek.bsky.social · 23/06/2026
New preprint! In collaboration with the Steinmetz Lab at PSI we report cryo-EM structures of microtubules at up to 1.9 Å (!) resolution & in different nucleotide state mimics, suggesting a mechanism for lattice-induced GTP hydrolysis and why it leads to catastrophe: tinyurl.com/7cjrf863
14927
Reposted by Kashish Singh
maxseidel.bsky.social @maxseidel.bsky.social · 19/06/2026
📢 (1/2) Excited to share the first preprint from my PostDoc! We developed UbSeRP to map co-translational ubiquitination in a translatome-wide, revealing thousands of quality control sites, and how they reshape with aging. www.biorxiv.org/content/10.6... #proteostasis #ribosomes #preprint
biorxiv.org
Ubiquitin selective ribosome profiling reveals systematic principles of co-translational quality control
Protein biogenesis is a stress- and error-sensitive process that can lead to nascent protein misfolding and aggregation, challenging cellular proteostasis. Co-translational ubiquitination (CTU) is a c...
14818
Reposted by Kashish Singh
Plaschka lab @plaschkalab.bsky.social · 18/06/2026
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
18035
Reposted by Kashish Singh
Andrii Bugai @abugai.bsky.social · 17/06/2026
Check out our latest research, just published in Nature @nature.com @molbiolau.bsky.social @au.dk Molecular basis of polyadenylated RNA fate determination in the nucleus www.nature.com/articles/s41...
nature.com
Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...
16027
Reposted by Kashish Singh
IMP @impvienna.bsky.social · 17/06/2026
How do cells distinguish functional genetic messages from molecular noise? Researchers in Clemens Plaschka's lab at IMP, together with Julius Brennecke's lab at IMBA and collaborators at Aarhus University, reveal a new principle of gene regulation: www.nature.com/articles/s41586-026-…
13014
Reposted by Kashish Singh
Helen Foster @helenfoster.bsky.social · 11/06/2026
There are lots of exciting opportunities to join the in situ structural biology community at Leeds this Autumn - 2 studentships in the Cheney PhD program (astbury.leeds.ac.uk/cheney-phd/) and I am recruiting a PhD student and research assistant. Please share and send any future tomographers our way!
astbury.leeds.ac.uk
Cheney Scholarship PhD Programme : The Astbury Centre for Structural Molecular Biology - "Understanding Life in Molecular Detail"
Applications are open for 2 PhD student places.  Closing date for applications is Thursday 26 June, 5pm. Interviews will be held on 9th July 2026. The Cheney Scholarship is a prestigious 4-year PhD pr...
11514
Reposted by Kashish Singh
Wieczorek Lab @mike-wieczorek.bsky.social · 14/06/2026
New preprint! In collaboration with @xujwet.bsky.social, @pedrobeltrao.bsky.social, and Akhmanova and Beekman groups, we determined the structure of the transition zone microtubule doublet in mammalian motile cilia, providing potential insights into the regulation of IFT: tinyurl.com/fssnevuc
tinyurl.com
Structure of the mammalian ciliary transition zone microtubule doublet
The ciliary transition zone gates bidirectional protein trafficking to maintain the specialized ciliary proteome using microtubule doublets as a scaffold. While ciliary axonemal doublets are well-char...
12915
Reposted by Kashish Singh
Tanmay Bharat @tbharat-lab.bsky.social · 08/06/2026
Disrupting phage liquid crystalline droplets restores antibiotic susceptibility in Pseudomonas aeruginosa biofilms out in @plosbiology.org by @abultarafder.bsky.social and team. Exciting collaboration with @geiselbiofilm.bsky.social @pearce-maths.bsky.social and others
14215
Reposted by Kashish Singh
Journal of Cell Biology @jcb.org · 05/06/2026
Design principles of human membrane protein topology. New study from Haoxi Wu @ox.ac.uk and Ramanujan S Hegde @mrclmb.ac.uk: rupress.org/jcb/article/... #membrane #lipid
0105
Reposted by Kashish Singh
Haaris Ahsan Safdari @haarissafdari.bsky.social · 03/06/2026
🚨 New in @natureportfolio.nature.com! 🚨 Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠 Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance. Read: doi.org/10.1038/s415...
doi.org
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome - Nature
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
0114
Reposted by Kashish Singh
Xin Xiang @xianglab.bsky.social · 03/06/2026
Really happy to share our latest work on the dynactin complex. We were so surprised to find that overexpression of dynactin p50 causes part of the dynactin complex to form clusters that contain our recently discovered dynactin assembly factor VezA/vezatin. www.biorxiv.org/content/10.6...
A model of dynactin cluster formation upon p50 overexpression.
043
Reposted by Kashish Singh
James Manton @jamesdmanton.bsky.social · 02/06/2026
We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...
Image of first two pages of manuscript.
14217
Reposted by Kashish Singh
Reese Richardson @reeserichardson.bsky.social · 28/05/2026
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
23591312
Reposted by Kashish Singh
Eva Karasmanis @evakarasmanis.bsky.social · 29/05/2026
New preprint alert! Ever wonder if cells can talk to each other? Tunneling nanotubes (TNTs) are tiny bridges between cells used to pass organelles, nucleic acids, proteins & even viruses but we've never seen inside them clearly. Until now! 👇🧵 biorxiv.org/content/10.64898/2026.05.27.728322v1
22211
Reposted by Kashish Singh
Allegretti Lab @matteoall.bsky.social · 27/05/2026
We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇
116755
Reposted by Kashish Singh
Tanmay Bharat @tbharat-lab.bsky.social · 25/05/2026
Sub-cellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging online @natmethods.nature.com, led by Hannah Ochner, collaboration with @catfranco.bsky.social and @kiranrpatil.bsky.social labs doi.org/10.1038/s415...
39751
Reposted by Kashish Singh
Victoria Deneke @vdeneke.bsky.social · 22/05/2026
How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇
2033891
Reposted by Kashish Singh
niels-fischer.bsky.social @niels-fischer.bsky.social · 07/05/2026
How do mitochondrial ribosomes keep pace with membrane insertion? Now out in NSMB: We show that mitoribosomes slow down at defined positions linked to membrane insertion and protein topology: rdcu.be/fhqIT #Mitochondria #Ribosome #CryoEM
rdcu.be
Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed
Nature Structural & Molecular Biology - Schöndorf and Petrychenko et al. show that mitochondrial translation speed is coupled to OXA1L-mediated inner membrane insertion, with...
34624
Reposted by Kashish Singh
Simon Bullock @simonbullock11.bsky.social · 05/05/2026
Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...
nature.com
Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
35834
Reposted by Kashish Singh
FocalPlane @focalplane.bsky.social · 01/05/2026
Our latest preprint list is now up on FocalPlane. This week, bioimage analysis takes centre stage! focalplane.biologists.com/2026/05/01/m... #microscopy #bioimageanalysis #preprints
focalplane.biologists.com
Microscopy preprints: bioimage analysis - FocalPlane
Microscopy preprints: bioimage analysis - News
0135
Reposted by Kashish Singh
Niakan Lab @niakanlab.bsky.social · 30/04/2026
Really exciting to see our new review published! This review explores the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering its biology. Check it out here: doi.org/10.1242/dev....
doi.org
The vertebrate yolk sac: evolutionary origins and current advances in in vitro models
Summary: This Review examines the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering ...
03513
Kashish Singh @kashishsingh.bsky.social · 29/04/2026
Check out this new study led by @amicoennio.bsky.social , with important contributions from @sami-c.bsky.social, @abidalilab.bsky.social and @leonmichalski.bsky.social. The work dissects how dynein–dynactin engages distinct adaptors to drive transport of diverse cargoes within cells.
091
Reposted by Kashish Singh
Sjors Scheres @sjorsscheres.bsky.social · 28/04/2026
The #ADFLIP approach by @kaiyi94.bsky.social and @kjamali.bsky.social, combined with their approach to backpropagation through #AlphaFold2, is really powerful. Keep tuned for more exciting results! 🥳
0184
Reposted by Kashish Singh
Kenneth Loi @kenjmloi.bsky.social · 27/04/2026
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
7448197
Reposted by Kashish Singh
FocalPlane @focalplane.bsky.social · 27/04/2026
We're excited to have our first webinar in our new webinar series on quantitative plant imaging happening this Thursday! For more info and to register for the webinar: focalplane.biologists.com/2026/03/30/n...
focalplane.biologists.com
New webinar series on plant imaging - FocalPlane
New webinar series on plant imaging - News
042
Reposted by Kashish Singh
Helena Watson @helenawatson.bsky.social · 25/04/2026
Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)
521368
Reposted by Kashish Singh
Haselbach Lab @haselbachlab.bsky.social · 23/04/2026
A new paper in which we could contribute structural insights to the great biochemical work from our collaborators from UNC Chapel Hill. Sascha Amann from our lab was yet again able to solve several very challenging structures. This time of a SCF with Protac and target www.nature.com/articles/s41...
nature.com
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22 - Nature Communications
Compound-mediated targeted protein degradation through the recruitment of Ub ligases is an emerging field. Here, the authors determine key structural and biochemical principles for harnessing SCF-FBXO...
1339
Reposted by Kashish Singh
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 22/04/2026
Congratulations to Manu Hegde, Group Leader & Joint Head of @cellbiol-mrclmb.bsky.social, who has been elected a member of the American Academy of Arts & Sciences. Congratulations also to the #LMBalumni joining him, Julie Ahringer & Edward Egelman. Read more: mrclmb.ac.uk/news-events/... #LMBNews
Manu Hegde smiling wearing a red jumper
0455
Reposted by Kashish Singh
British Society for Cell Biology @bscb-official.bsky.social · 23/04/2026
Eva Simpson (University of Nottingham) is awarded the 2026 Raff Medal PhD Award at #DynamicCellVI by our PhD Rep @harrietasmith.bsky.social, before her fantastic medal talk about her research using 3D-CLEM to study meiotic chromosome organisation Congratulations Eva 👏👏
0113
Reposted by Kashish Singh
British Society for Cell Biology @bscb-official.bsky.social · 23/04/2026
Fantastic talk from our 2026 Postdoc ECR Medal Winner @giuliapaci.bsky.social from @lmcb-ucl.bsky.social at #DynamicCellVI explaining her research on the role of 3D epithelial topology in developmental patterning Congratulations Giulia 👏👏
0248
Reposted by Kashish Singh
British Society for Cell Biology @bscb-official.bsky.social · 22/04/2026
Hooke Medal winner Stephen Tait @mitosrus.bsky.social @cruk-si.bsky.social is presented with his medal by BSCB president Laura Machesky before his fantastic medal talk on 'mitochondria, death and something in between' #DynamicCellVI
1189
Reposted by Kashish Singh
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 20/04/2026
Don’t miss next week’s #LMBSeminar from Clemens Plaschka (@plaschkalab.bsky.social), Senior Group Leader at IMP, Vienna. Beginning at 11am (BST) on Monday 27 April, Clemens will join us to discuss ‘Mechanisms of mRNA packaging and export’ Visit our website for more info: mrclmb.ac.uk/news-events/...
Announcement for a lecture by Clemens Plaschka from Vienna's Research Institute of Molecular Pathology on mRNA packaging and export, scheduled for Monday 27th April at 11am BST.
052
Reposted by Kashish Singh
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 15/04/2026
The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year. Applications are open now! More details: mrclmb.ac.uk/careers-and-... Please share this post with anyone who may be interested!
Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.
01517
Reposted by Kashish Singh
Sjors Scheres @sjorsscheres.bsky.social · 10/04/2026
Dimerisation and twist reversal of the Lewy fold in alpha-synuclein mutants with Parkinson's disease and dementia. Together with Yang Yang (now at @vai.org) and Michel Goedert. 🥳 www.biorxiv.org/content/10.6...
biorxiv.org
1174
Reposted by Kashish Singh
Noah Turner @noahnturner.bsky.social · 10/04/2026
Happy to see our paper describing cryo-EM structures of the budding yeast KMN kinetochore complex published in @jcb.org! Our structure reveals how an important hub mediates and regulates assembly of the machine that segregates chromosomes. #cryo-EM @mrclmb.ac.uk 🔗 rupress.org/jcb/article/...
Composite cryo-E M density map of the yeast K M N junction complex, showing the structure and interactions of K M N junction complex.
33410
Reposted by Kashish Singh
Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
312962
Reposted by Kashish Singh
(GIRISH)MALI LAB @dyneinassembly.bsky.social · 07/04/2026
Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint. 'Motile ciliophagy promotes ciliary recycling under stress' www.biorxiv.org/content/10.6...
biorxiv.org
14010
Reposted by Kashish Singh
Sjors Scheres @sjorsscheres.bsky.social · 02/04/2026
Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳 With Michel Goedert and Masato Hasegawa. www.biorxiv.org/content/10.6...
biorxiv.org
13619
Reposted by Kashish Singh
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 31/03/2026
On 27th April, we’ll be welcoming Clemens Plaschka back to the LMB to present an #LMBSeminar on ‘Mechanisms of mRNA packaging and export’ Clemens, previously an LMB postdoc, is now a Senior Group Leader at IMP, Vienna - @plaschkalab.bsky.social. Talk details: mrclmb.ac.uk/news-events/...
Announcement for a lecture by Clemens Plaschka from Vienna's Research Institute of Molecular Pathology on mRNA packaging and export, scheduled for Monday 27th April at 11am BST.
0112
Reposted by Kashish Singh
Jeff Lengyel & TEM Team at Thermo Fisher Scientific @jefflengyeltemteam.bsky.social · 31/03/2026
It's a big day for our team. Excited to share the launch of the Thermo Scientific™ Glacios™ 3 Cryo-TEM, our latest 200 kV #cryoEM platform. High-performance imaging with the Thermo Scientific™ READY™ System that can lower installation time and infrastructure costs. Learn more: ter.li/alac5m
0114
Reposted by Kashish Singh
Clinton Lau @ckylau.bsky.social · 30/03/2026
Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...
37427
Reposted by Kashish Singh
Oli Clarke @olibclarke.bsky.social · 27/03/2026
Extended this (map_salami) a bit - added a movie option which will generate a labeled movie (1080p or 4k) transitioning between all scenes, with a short rocking motion at each scene for depth perception:
3246
Kashish Singh @kashishsingh.bsky.social · 27/03/2026
So well deserved. Congrats @vcmentowski.bsky.social !!
010