Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved. We propose the “immunometabolic gatekeeping” framework, whereby tissue-intrinsic metabo...

(White et al., Cancer Research UK Scotland Institute and collaborators across the MRC National Mouse Genetics Network – Cancer Cluster) Colorectal cancer (CRC) is a genetically complex disease, yet re...

Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules that recruit an ubiquitin ligase (E3) and a neo-substrate into a ternary complex, enabling selective protein degradation. Desp...

The research focused on the genetic faults that allow the disease to hijack a signalling system in the body.

Npm1 promotes tumor formation via attenuating the integrated stress response and p53 activation in mouse WNT-driven intestinal and liver tumorigenesis.

YouTube video by Fiona MacLeod

Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...

Cancer Research Horizons Biosciences Student Placement (Lab based) £23,000 plus benefits Directorate: Research & Innovation Contract: Fixed Term Contract 52 weeks Hours: Full time 35 hours per wee...

YouTube video by CRUK Manchester Institute

Alexander Raven, an early career researcher from the School of Cancer Sciences, has been awarded one of UK Research and Innovation’s (UKRI) flagship Future Leaders Fellowships.

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Self-learning artificial intelligence approaches are offering a number of advantages for digital pathology when compared to established AI options. The benefits, which range from greater speed and cap...

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Scientists at the Cancer Research UK Scotland Institute, based at the University of Glasgow, have made a discovery which could help stop the spread of breast cancer – one of the leading causes of deat...

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk