Sign in

MRC-LMB Cell Biology Division

@cellbiol-mrclmb.bsky.social
4K followers 1.9K following 63 posts

Our aim is to understand the biological organisation of cells and organisms, and the molecular mechanisms underlying their function. www2.mrc-lmb.cam.ac.uk/research/cel…

PostsRepliesMedia
Reposted by MRC-LMB Cell Biology Division
Stefano Giandomenico @sgiando.bsky.social · 30/09/2026
Can a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠 We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪 www.biorxiv.org/content/10.6... 🧵 1/5
12111
Reposted by MRC-LMB Cell Biology Division
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 01/10/2026
Interested in cerebral organoids? 🧠 Don’t miss the latest episode of Unexpected Elements from BBC World Service, featuring @apadonovan.bsky.social, Postdooctoral Fellow in @lancasterlab.bsky.social’s group in @cellbiol-mrclmb.bsky.social. Catch it here: www.bbc.co.uk/sounds/play/... #LMBintheNews
bbc.co.uk
Unexpected Elements - An identity crisis - BBC Sounds
A case of mistaken identity inspires us to explore the science of getting things wrong.
051
Reposted by MRC-LMB Cell Biology Division
Matthew Freeman @mjafreeman.bsky.social · 30/09/2026
Yet another opportunity @dunnschool.bsky.social! We are looking for an Associate Professor If you have exciting research plans, @dunnschool.bsky.social is a great place: excellent science (and lovely people, obvs) www.path.ox.ac.uk/vacancy/asso...
path.ox.ac.uk
Associate Professorship of Cancer Biology - Sir William Dunn School of Pathology in association with the Queen’s College. - Dunn School
We are seeking to appoint an Associate Professor working in the area of the cellular and/or molecular biology of cancer, to be based in Oxford University’s Sir William Dunn School of Pathology. The ro...
01828
Reposted by MRC-LMB Cell Biology Division
Mathilda Lennartz @mathilda95.bsky.social · 30/09/2026
UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....
nature.com
Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology
Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...
711246
Reposted by MRC-LMB Cell Biology Division
Jez Carlton @jezcarlton.bsky.social · 28/09/2026
Hey! Submit your papers, and spread the word, this will be great! Thanks for inviting us @jcellsci.bsky.social and great to work with @pihanson.bsky.social on this issue!
02324
Reposted by MRC-LMB Cell Biology Division
Buzz Baum @buzzbaum.bsky.social · 22/09/2026
We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...
jobs.ac.uk
Research Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
02846
Reposted by MRC-LMB Cell Biology Division
Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
4292142
Reposted by MRC-LMB Cell Biology Division
Felix Campelo @felixmendu.bsky.social · 16/09/2026
This is tomorrow (thursday, 5pm CET)! Join us for the first session of the #membranetrafficking seminars after the break :)
055
Reposted by MRC-LMB Cell Biology Division
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 16/09/2026
How do cells remove abnormal glycogen? Led by Matthew Yip, using mouse models, cell engineering & cryo-ET, Felix Randow's group found that RNF213 ubiquitylates aberrant glycogen to trigger autophagy. mrclmb.ac.uk/news-events/articles/h… #LMBResearch
03017
Reposted by MRC-LMB Cell Biology Division
In Preparation @inprep.bsky.social · 15/09/2026
inpreparation.substack.com
HHMI Launches Initiative To Support Scientists Who Attended Second-Tier Ivies
CHEVY CHASE, MD—In a landmark effort to expand opportunity in the biomedical sciences, the Howard Hughes Medical Institute announced Tuesday a new $200 million initiative to support scientists from…
2142
Reposted by MRC-LMB Cell Biology Division
Cell Biology J-Club @cellclub.bsky.social · 15/09/2026
New on CLN8 - a previously defined ER-cargo receptor: The Batten disease protein CLN8 is a stereospecific acyltransferase in bis(monoacylglycero)phosphate biosynthesis www.nature.com/articles/s41...
nature.com
The Batten disease protein CLN8 is a stereospecific acyltransferase in bis(monoacylglycero)phosphate biosynthesis - Nature Cell Biology
Two studies show that the endoplasmic reticulum-associated protein CLN8 catalyses the acyl CoA-dependent acylation of glycerophosphoglycerol, producing lysophosphatidylglycerol, which is then converte...
063
Reposted by MRC-LMB Cell Biology Division
Sjors Scheres @sjorsscheres.bsky.social · 15/09/2026
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...
nature.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
01628
Reposted by MRC-LMB Cell Biology Division
Alex Ludwig @alexludwig.bsky.social · 14/09/2026
How do epithelial cells make a lumen as they polarize? We have some exciting new answers to this long standing question. Check out our new paper in which we show that lumen initiation is driven by large vacuoles that deliver a pre-assembled apical cortex to the AMIS: www.nature.com/articles/s41...
nature.com
Bulk delivery of a preassembled apical surface initiates epithelial lumen formation - Nature Communications
Epithelial lumen formation is fundamental to organ development, yet how apical surfaces first emerge remains unclear. Ghosh, Martin, and Chen et al., show that lumen initiation is driven via bulk deli...
03312
Reposted by MRC-LMB Cell Biology Division
Marta Shahbazi @marta-shahbazi.bsky.social · 11/09/2026
Really happy and honoured! Thank you so much!
8627
Reposted by MRC-LMB Cell Biology Division
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 11/09/2026
Ready to take the next step in your research career? The LMB is now accepting applications for PhD placements starting in October 2027. Deadline: 08 December 2026 (allow time for reference submission). Discover what we offer here: mrclmb.ac.uk/careers-and-people/phd…
034
Reposted by MRC-LMB Cell Biology Division
Alex von Tunzelmann @alexvont.bsky.social · 10/09/2026
If you feel like donating to the RNLI, here’s a link. I just have. Their minimum donation is £2: I think it might be nice for them to receive a lot of donations this week, even if they’re mostly very modest. Just so they know a lot of people out here appreciate their work. rnli.org/support-us/g...
rnli.org
Donate to the RNLI and help save lives at sea
Your donations really make a difference. We depend on your generosity to educate people to stay safe and prevent tragedies on and offshore. Donate here.
4920921254
Reposted by MRC-LMB Cell Biology Division
Matthew Freeman @mjafreeman.bsky.social · 08/09/2026
Feels like an interesting one... oh, wait...!
0145
Reposted by MRC-LMB Cell Biology Division
Antoine Molaro @antoinemolaro.bsky.social · 09/09/2026
Hello World ! Reminder about our open postdoc position 🧪🧬 Reviewing applications until October - get in touch to know more about what's hot in the lab these days ! Application details in the post below 👇👇 #EvoEpi #MolaroLab #watwat #ERC
0416
Reposted by MRC-LMB Cell Biology Division
Pedro Beltrao @pedrobeltrao.bsky.social · 09/09/2026
I made a presentation to other faculty about recent progress in general AI, to facilitate the discussion around the impact for research and teaching in biology. It could be that the slides are useful for others trying to do that same. Feel free to re-use. docs.google.com/presentation...
docs.google.com
generalAI_for research_intro.pptx
Recent AI developments and what they mean for us Quick primer on general AI models* State-of-the-art in AI agent capabilities AI agents in biology (examples) Discussion - what does this mean for our r...
79026
Reposted by MRC-LMB Cell Biology Division
Cell Biology J-Club @cellclub.bsky.social · 08/09/2026
The rhomboid-like pseudoprotease TMEM115 defines a two-factor mechanism for Rab6A effector recruitment www.biorxiv.org/content/10.6...
biorxiv.org
The rhomboid-like pseudoprotease TMEM115 defines a two-factor mechanism for Rab6A effector recruitment
Protein trafficking and organelle identity depends on precise localisation of membrane proteins, anchored by small GTPases that bind to specific cellular compartments. Here we show that the rhomboid-l...
062
Reposted by MRC-LMB Cell Biology Division
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 08/09/2026
The rhomboid-like pseudoprotease TMEM115 defines a two-factor mechanism for Rab6A effector recruitment www.biorxiv.org/content/10.64898/20…
032
Reposted by MRC-LMB Cell Biology Division
Journal of Cell Biology @jcb.org · 07/09/2026
Hoi1 targets BLTP2 to ER–PM contact sites to regulate lipid homeostasis. From Samantha K. Dziurdzik, Vaishnavi Sridhar, @lizconibear.bsky.social and colleagues: rupress.org/jcb/article/... 📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti... #EMBOLipidCode
053
Reposted by MRC-LMB Cell Biology Division
Ishier Raote @ishier.bsky.social · 07/09/2026
Membrane Trafficking Seminar Series 2026 fall season is here! An exciting programme: membrane traffic, organelle biogenesis, lipid transport, endomembrane evolution, we have it all! Save the dates and join us for fun science and discussions. Details at felixcampelo.wixsite.com/membranetraf...
22725
Reposted by MRC-LMB Cell Biology Division
Journal of Cell Biology @jcb.org · 07/09/2026
The cell biologist’s guide to detecting and modulating membrane #phospholipids. A review by Worcester, @gerryhammond.bsky.social and colleagues: rupress.org/jcb/article/... 📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti... #EMBOLipidCode
01611
Reposted by MRC-LMB Cell Biology Division
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/09/2026
The complete #connectome of the adult Drosophila male CNS has allowed researchers, inc @jefferis.bsky.social’s group, to compare male & female brains at synaptic-resolution for the first time. Read more here: mrclmb.ac.uk/news-events/... #LMBResearch 1/2
18129
Reposted by MRC-LMB Cell Biology Division
FlyBase @flybase.bsky.social · 02/09/2026
As you may know, NIH abruptly terminated funding to FlyBase curators based in the United Kingdom. Please help us retain these curators and thereby enable ongoing curation of bibliographic, genetic and phenotypic data by contributing annually (tinyurl.com/4jw65mbb). Thank you. #FlyBase
tinyurl.com
FlyBase:Contribute to FlyBase - FlyBase Wiki
02723
Reposted by MRC-LMB Cell Biology Division
The EMBO Journal @embojournal.org · 25/08/2026
How are perforin-2 immune functions in attacking bacteria & in antigen cross-presentation coordinated? @patrycja-kozik.bsky.social et al find its extensive proteolytic processing, but antigen trafficking in dendritic cells selectively requires the full-length form link.springer.com/article/10.1...
link.springer.com
Anchoring of perforin-2 via the transmembrane domain is required for antigen escape into the cytosol - The EMBO Journal
Perforin-2 is a pore-forming protein localised to the endocytic compartments of dendritic cells and macrophages. It is reported to perform two distinct functions during immune responses: attacking int...
043
Reposted by MRC-LMB Cell Biology Division
Robert Arkowitz @robertarkowitz.bsky.social · 01/09/2026
🔬🧪🦠 An exciting opportunity to work at the interface of Fungal Cell Biology & Biophysics in Nice, FR in a collaborative project on roles of cytoplasmic crowding in fungal pathogen morphogenesis, antifungal responses and host interaction. ibv.unice.fr/news/postdoc... Please share/retweet
Postdoc or Research associate/engineer position
in Fungal Cell Biology/Biophysics
2713
MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · 28/08/2026
Great tribute to the discovery by Barbara Pearce of clathrin, the first protein found to act in membrane traffic, along with her mentoring and support of the pioneers (many of whom were other women) who revealed the workings of this key player in cellular function.
03419
Reposted by MRC-LMB Cell Biology Division
Mothers in Science @mothersinsci.bsky.social · 28/08/2026
Join our team! 📣 If you are passionate about creating a more equitable system for mothers & caregivers in STEMM, can commit 2h per week & have experience in writing or content creation, we'd love to hear from you! Apply now👇https://tinyurl.com/yc3kx4m8
001
Reposted by MRC-LMB Cell Biology Division
Mark Peifer (He, him) @peiferlabunc.bsky.social · 26/08/2026
Pro tip: Most of these @dshb-antibodies.bsky.social Abs are documented in dozens of publications and are also substantially cheaper.
15529
Reposted by MRC-LMB Cell Biology Division
Kurianlab @kurianlab.bsky.social · 26/08/2026
dshb.biology.uiowa.edu We should support and make better use of hybridoma bank Maintained by a small team at the University of Iowa’s Developmental Studies Hybridoma Bank
dshb.biology.uiowa.edu
Developmental Studies Hybridoma Bank - DSHB
High quality, low cost antibodies.
12315
Reposted by MRC-LMB Cell Biology Division
Mary Munson @marymunson4.bsky.social · 26/08/2026
Structural biology postdoctoral position open in my lab--apply now! For more information about the lab, see www.umassmed.edu/munsonlab/. Interested candidates should apply through the University of Massachusetts Chan Medical School jobs portal (www.ummsjobs.com/job/11668/).
umassmed.edu
Munson Lab | Home | BMB | UMass Chan Medical School
The Munson Lab researches the mechanistic basis for the regulation of spatial and temporal specificity in membrane trafficking in the Biochemistry & Molecular Biotechnology Department at UMass Chan Me...
12744
Reposted by MRC-LMB Cell Biology Division
André Nadler @nadlerlab.bsky.social · 21/08/2026
Rocket science. The NMR part is a true stunner. Let me put it very kindly: We ain't there yet & burning through god knows how much compute time to achieve something that "the operating software of the spectrometer" does automatically & instantly... www.anthropic.com/research/Cla...
anthropic.com
How Claude is accelerating protein design and analytical chemistry
In this post, we share two results that show how Claude can help life scientists increase the pace of their research. In the first, we tested Claude’s ability to design protein binders from scratch, a...
1102
Reposted by MRC-LMB Cell Biology Division
FlyBase @flybase.bsky.social · 20/08/2026
Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...
nature.com
Treat biological databases as infrastructure, not projects
Letter to the Editor
17645
Reposted by MRC-LMB Cell Biology Division
The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 18/08/2026
An extra vid today 🙌 Lister Fellow @kellythd-nguyen.bsky.social shares her research on telomerase. Using cryo-electron microscopy, she's been able to see the structure of this enzyme and make sense of many disease mutations. 👀 www.youtube.com/watch?v=ciP2... 📖 www.eppendorf.com/gb-en/compan...
youtube.com
The balance at the ends of our chromosomes - Kelly Nguyen on Telomerase, Aging and Balance
One of the rarest molecules in the human body is the enzyme complex telomerase. Yet it can decide our fate, in terms of ageing, cancer and some inherited diseases. Kelly Nguyen studies how the…
062
Reposted by MRC-LMB Cell Biology Division
Cell Biology J-Club @cellclub.bsky.social · 18/08/2026
Architecture and mechanism of the human p24 cargo receptor | PNAS www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
022
Reposted by MRC-LMB Cell Biology Division
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 18/08/2026
Exciting plans for a new national hub at @scicambridge.bsky.social to advance novel alternative methodologies for disease models. @lancasterlab.bsky.social will co-lead neuroscience models, including brain organoids. Read more: www.bbc.co.uk/news/article... #LMBintheNews @cellbiol-mrclmb.bsky.social
bbc.co.uk
Plans for £20m hub in Cambridge to develop new medicines using AI
The hub is funded by the Medical Research Council and based at Cambridge Biomedical Campus.
074
Reposted by MRC-LMB Cell Biology Division
In Preparation @inprep.bsky.social · 18/08/2026
inpreparation.substack.com
PI Who Took Credit For Paper Clarifies Fraud Was Student’s Independent Work
BOSTON, MA—In a statement released Monday following the retraction of a high-profile Nature paper, Whitehead Institute principal investigator Dr.
2167
Reposted by MRC-LMB Cell Biology Division
Jon Humphries @jdhl18.bsky.social · 16/08/2026
And here's the direct link to the JCS at a glance archive: journals.biologists.com/jcs/search-r...
journals.biologists.com
Validate User
065
Reposted by MRC-LMB Cell Biology Division
Mill_lab @cilialab.bsky.social · 16/08/2026
Join us for the 56th BSCB GenSoc UK Cilia & Centrosome Network e-symposium! 🧪Free & for all! /1 🗓️ AUGUST 25th 2026 ⌚ 15:00-17:30 BST | 16:00-18:30 CEST | 10:00-12:30 EDT ukcilianetwork.bsky.social gensocuk.bsky.social @bscb-official.bsky.social Register once: www.eventbrite.co.uk/e/bscb-genso...
eventbrite.co.uk
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
175
Reposted by MRC-LMB Cell Biology Division
Lori Passmore @lapassmore.bsky.social · 14/08/2026
Ben Nicholson at the CRUK Cambridge Institute is recruiting a new postdoc to investigate piRNA biology. This is a collaborative project with my group at MRC Laboratory of Molecular Biology (LMB). Interested? Apply or get in touch to discuss! tinyurl.com/y25z8wkn
cam.ac.uk
Postdoctoral Research Associate (piRNA Team) (Fixed Term)
The Cancer Research UK Cambridge Institute is situated on the Biomedical Campus in Cambridge, UK. As part of the University of Cambridge, the institute's research ranges from basic biology through tra...
0127
Reposted by MRC-LMB Cell Biology Division
Cell Biology J-Club @cellclub.bsky.social · 11/08/2026
www.biorxiv.org/content/10.6...
biorxiv.org
Cornichon receptors couple membrane adaptation to cargo selection during ER export
Selective export of membrane proteins from the endoplasmic reticulum (ER) is fundamental for eukaryotic cell biology, yet how trafficking receptors coordinate cargo recognition with membrane adaptatio...
032
Reposted by MRC-LMB Cell Biology Division
Heran Darwin, PhD @heran.bsky.social · 10/08/2026
BlueSky doesn't seem to spread the word around as effectively as that other app so I'm reposting this incredible opportunity again (and again!). Please repost and spread the word to strong candidates. Thank you!
0511
Reposted by MRC-LMB Cell Biology Division
In Preparation @inprep.bsky.social · 07/08/2026
inpreparation.substack.com
Pharma Executives Confident China Cycle That Has Happened To Every Other Industry Will Not Happen To Pharma
CAMBRIDGE, MA—Expressing calm assurance that the pattern of technology transfer, appropriation, and eventual displacement that has occurred in manufacturing, solar panels, semiconductors, telecommunications,...
0136
Reposted by MRC-LMB Cell Biology Division
dshb-antibodies.bsky.social @dshb-antibodies.bsky.social · 05/08/2026
What antibody question keeps coming up in your lab? The DSHBlog shares practical guidance, research stories, and the knowledge behind widely used reagents—so what works at the bench is easier to find and share. dshb.biology.uiowa.edu/blog
dshb.biology.uiowa.edu
blog
001
Reposted by MRC-LMB Cell Biology Division
Heran Darwin, PhD @heran.bsky.social · 03/08/2026
Please don't miss this opportunity to work with a brilliant, patient and rigorous scientist!!
043
Reposted by MRC-LMB Cell Biology Division
Liz Miller @lizmillercu.bsky.social · 31/07/2026
Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...
dundee.ac.uk
Postdoctoral Research Assistant - UOD2336
Closing date: Thursday 27 August 2026, 23:59
01425
Reposted by MRC-LMB Cell Biology Division
Journal of Cell Science @jcellsci.bsky.social · 29/07/2026
Igor Yakunin, Sean Munro @cellbiol-mrclmb.bsky.social and colleagues find that the Golgi vesicle tether p115 can bind directly to the ER exit site organiser Sec16A. #OpenAccess #ReadandPublish journals.biologists.com/jcs/article/...
AlphaBridge visualisation of the output from an AlphaFold 3 prediction of a complex between the N-terminal region of Sec16A (1–1100) and the head domain of p115 (1–630). Shown in orange and blue are the two high-confidence interactions identified by AlphaBridge, both of which have a predicted interaction confidence score (piCS) of 0.91 (Álvarez-Salmoral et al., 2025 preprint). The predicted local distance difference test (pLDDT) score of ≤50 indicates that most of the indicated region of Sec16A is predicted to be unstructured. (C) AlphaFold 3 prediction of the complex formed between residues 701–755 of Sec16A and the head domain of p115. The residues of Sec16A lie along a groove in the surface of p115, with two regions predicted to interact with very high confidence. Shown in red are short stretches of residues in the middle of each region that were selected for mutation to alanine.
0126
Reposted by MRC-LMB Cell Biology Division
Julian Sale @juliansalelab.bsky.social · 27/07/2026
Growing up in the Northwest, Jodrell Bank helped inspire my interest in science. To hear of its funding being cut by @ukri.org is extremely sad, and an act of monumental vandalism that diminishes UK science in so many ways, including its ability to excite little kids... www.bbc.co.uk/news/article...
bbc.co.uk
Jodrell Bank's Lovell telescope faces axe in science cuts, BBC understands
Astronomers warn it would tear the heart out of UK science, and leave a generation untrained.
094