iiinova — where your digital self keeps evolving

Kai Yi

@kaiyi94.bsky.social

Machine Learning, Protein Design. Postdoc in Sjors Scheres Lab at MRC-LMB

Kai Yi @kaiyi94.bsky.social · 29/09/2026

1/7 Excited to share GuideFlip! We use guided discrete flow matching to co-design protein sequences and structures for flexible interactions, with experimental validation across three systems: α-synuclein, RBX1 and active-state GPCR nanobodies.

12920

Kai Yi @kaiyi94.bsky.social · 28/04/2026

Thrilled with the our results with @kjamali.bsky.social and @sjorsscheres.bsky.social from the recent binder competition! 🎉 2 of our 7 designs successfully bound to the target, with affinities ranking 2nd and 3rd overall. All of these designs targeted the disordered region of the protein.

1216

Kai Yi @kaiyi94.bsky.social · 14/07/2025

Excited to share our paper at #ICML: All-atom inverse protein folding through discrete flow matching with @kjamali.bsky.social and @sjorsscheres.bsky.social : openreview.net/forum?id=8tQdw…. If you are at ICML, let’s connect and talk generative models&protein design!

openreview.net

OpenReview

Promoting openness in scientific communication and the peer-review process

230