Objective To explain discrepant findings for fluoxetine's efficacy in three influential network meta-analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recomme.....

YouTube video by Quarks

Michael J. Fox

A free browser extension that marks antibodies cited in a paper with their knockout-controlled validation status, for the application they were used in.

A patient with WHIM syndrome, caused by CXCR4 chemokine receptor hyperactivity, had sustained remission after splenic rupture. A somatic mutation produced CXCR4 haploinsufficiency, suggesting allel...

A man in his mid 60s with a history of resected primary cutaneous melanoma then developed metastatic BRAF V600E mutant disease involving lymph nodes, liver and bone. He was unable to tolerate 2 months...

After several examples of undisclosed alterations in reagent suppliers’ antibody catalogues surfaced, researchers call for transparency to rebuild trust.

Apparent manipulation of validation images in reagent catalog concerns researchers

In recent years, the acronym NRF2 has garnered significant attention in scientific discourse. However, this attention has occasionally led to confusion due to the existence of two distinct proteins sh...

If your week flew by — we know ours did — catch up here with what you might have missed. The week at Retraction Watch featured: Critics of birdsong study fight to be named in Nature’s retraction El…

Scientists have long worried about the reliability of commercial antibodies, and the latest findings have sparked fresh concerns.

Scientists have long worried about the reliability of commercial antibodies, and the latest findings have sparked fresh concerns.

Scientists have long worried about the reliability of commercial antibodies, and the latest findings have sparked fresh concerns.

A free, searchable database of knockout-validated antibody characterisation data covering 155 genes and 1617 antibodies. Includes a free e-learning Academy.

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

Recent Image generation and LLM models are so good they can produce digital assets nearly undistinguishable from genuine ones.

Failure is part and parcel of research, but discussing it sometimes seems to be taboo in science. It doesn’t need to be.

Data on almost 28,000 patients suggests understanding gene variations could improve treatments for obesity

A free, searchable database of knockout-validated antibody characterisation data covering 147 genes and 1496 antibodies. Includes a free e-learning Academy.

Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.