Le Rest et al. identify ZC3H18 as the long-sought molecular link between the cap-binding complex (CBC) and first intron splicing. ZC3H18 recruits early splicing factors through interactions that are mutually exclusive with RNA decay factor binding, implying how cap-bound nascent transcripts are directed toward productive splicing rather than degradation.

Ledig stilling ved Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet

Vacancy at RNA Biology and Innovation, Aarhus University

Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradation.

Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...