Bacterial ribosomes can synthesize proteins encoded within their own RNA.

Nature Reviews Microbiology, Published online: 19 June 2026; doi:10.1038/s41579-026-01336-5This study describes the discovery of a new antibiotic with a previously unknown mode of action.

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...

Four antibiotic compounds produced in Streptomyces bacteria attack multiple parts of an essential metabolic pathway.

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...

Researchers at McMaster University have discovered a new antibiotic that kills some of the world’s most dangerous and drug-resistant bacteria — and does so by targeting a previously unknown…

Researchers discover manikomycin, a novel antibiotic that kills drug-resistant bacteria by targeting a previously unknown ribosomal target.

Researchers tested their newly discovered peptide against one common antibiotic-resistant bacteria. Only about one in every hundred million survived to pass on genetic resistance.

The increasing democratization and implementation of electron cryo-microscopy appears poised to drive a new revolution in digital structural biology.

Nature Communications - Ribosome hibernation preserves translation machinery during stress. Here, the authors identify a ribosome hibernation factor that is widespread in archaea and combines...

Nature - Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting...

This study describes the discovery of a new antibiotic with a previously unknown mode of action.

In this work authors show how minimal mutations in proline-rich antimicrobial peptides can flip their orientation in the ribosome exit tunnel, switching their mechanism from stalling translation termination to halting initiation - revealing a possible host strategy against evolving pathogens.

How do bacteria regulate the production of their proteins? Researchers at the University of Hamburg, in collaboration with international partners, have now demonstrated how small protein building blocks, known as peptides, specifically influence bacterial protein production.

This study describes the discovery of a new antibiotic with a previously unknown mode of action.

This study describes the discovery of a new antibiotic with a previously unknown mode of action.

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...

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Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...

The lead scientist on the use of ‘base editing’ in very early embryos say that the technique is far from ready for the clinic, but critics worry that the work will spur a rush to commercialization.

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...

Researchers discover manikomycin, a novel antibiotic that kills drug-resistant bacteria by targeting a previously unknown ribosomal target.

Ausgerechnet ein lange erforschter Mikroorganismus liefert einen bislang unbekannten Wirkstoff gegen multiresistente Keime. Manikomycin ist noch weit von der Klinik entfernt – zeigt aber, wo die Antib...

Ribosome arrest peptides undergo programmed translational stalling in response to changes in the cellular environment to feedback-regulate gene expression. CliM, an arrest peptide in Clostridia, is en...

CliM is a ribosome arrest peptide in Clostridia. Here, the authors show that CliM adopts helices and extensively interacts with the ribosome. The penultimate residue sterically blocks A-site accommoda...

In this work authors show how minimal mutations in proline-rich antimicrobial peptides can flip their orientation in the ribosome exit tunnel, switching their mechanism from stalling translation termi...

In this work authors show how minimal mutations in proline-rich antimicrobial peptides can flip their orientation in the ribosome exit tunnel, switching their mechanism from stalling translation termi...

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...