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Simon Bullock

@simonbullock11.bsky.social
1.5K followers 498 following 32 posts

Molecular motors, mRNA localisation, microscopes4schools, MRC-LMB (Cambridge, UK)

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Reposted by Simon Bullock
Katja Petzold @katjapetzold.bsky.social · 01/10/2026
We’re looking for postdocs to explore RNA dynamics in biologically relevant conditions in an international and genuinely curious research team. If you’re interested in RNA changing its shape to perform its function (even inside a living cell), we'd love to hear from you. Details: petzoldlab.com
petzoldlab.com
Home
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Journal of Cell Biology @jcb.org · 30/09/2026
Abir Elfarkouchi, Arthur Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...
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Joe Greener @jgreener64.bsky.social · 30/09/2026
I gave a teaching lecture on molecular dynamics this morning. If anyone is interested in the slides they are at docs.google.com/presentation....
docs.google.com
LJC Summer School lecture
Molecular Dynamics Joe Greener MRC Laboratory of Molecular Biology LJC Summer School - 30/09/26
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Stefano Giandomenico @sgiando.bsky.social · 30/09/2026
Can a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠 We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪 www.biorxiv.org/content/10.6... 🧵 1/5
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James Manton @jamesdmanton.bsky.social · 29/09/2026
I've been working on a fast, high-ratio image compressor to try and alleviate the data storage issues myself and some of my colleagues have recently been facing. Before I 'release' version 1, it'd be great to gain some feedback regarding performance and missing features. github.com/jdmanton/rad...
github.com
GitHub - jdmanton/radelta
Contribute to jdmanton/radelta development by creating an account on GitHub.
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Will Ratcliff @wcratcliff.bsky.social · 28/09/2026
New paper out with @kaylastoy.bsky.social: academic.oup.com/evlett/advan...
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Simon Bullock @simonbullock11.bsky.social · 28/09/2026
How are mRNAs linked to molecular motors in mammalian cells? In our new preprint, we show that FXR1/2 are RNA adaptors for the microtubule motor dynein. Our findings have also prompted us to rethink how activating adaptors contribute to motor-based transport (1/n)
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 28/09/2026
Are you looking for a postdoc exploring the cell biology of development, defining how cells change shape and move? Do you want to develop a research program & teaching skills preparing you for a position at a college or small University? Our new NIH grant will support those goals 1/n Please share
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Michael Way @drmichaelway.bsky.social · 26/09/2026
Arp2/3 iso-complexes strike again! Axonal actin ring assembly and maintenance involves different iso-complexes that change expression during neuronal maturation 🎉 Great collaboration with Ana Rita Costa & Monica Sousa @ i3S in Porto www.i3s.up.pt/research-gro... www.science.org/doi/10.1126/...
science.org
Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity
The actin-related protein 2/3 (Arp2/3) complex is a central nucleator of branched actin filaments, essential for numerous cellular processes. Using superresolution imaging, we demonstrate that Arp2/3 ...
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Steve Russell @steverus.bsky.social · 24/09/2026
We’re recruiting to an assistant/associate professorship in Pathogen Genetics- come and join us. www.cam.ac.uk/jobs/assista...
cam.ac.uk
Assistant/Associate Professor in Pathogen Genetics
Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...
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Saba Parvez @sparvez.bsky.social · 23/09/2026
My lab at Northwestern University is recruiting a postdoctoral fellow to study alternative splicing, NMD, and gene regulation in vertebrate development and regeneration. We use zebrafish large-scale functional genetics, genomics, and high-throughput phenotyping.
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Institute of Molecular Biotechnology @imbavienna.bsky.social · 23/09/2026
Can “jumping genes” spread like viruses? New research from the Brennecke lab at IMBA shows that, in fruit flies, certain transposable elements can break out of their own cell and slip into developing eggs—securing their passage to the next generation. Published in Cell: imba.science/4jdMuYQ
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Buzz Baum @buzzbaum.bsky.social · 22/09/2026
We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...
jobs.ac.uk
Research Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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adam grieve @adamgrieve.bsky.social · 17/09/2026
What if a membrane protein’s movement is as important as what it does? Our latest work reveals the unrestricted lateral mobility of a rhomboid protease enables neuronal synapse remodelling tinyurl.com/yk6xfxzr All credit to @annabodzeta.bsky.social for this stunning work, who is on the job hunt!
A cartoon depicting the unhindered movement of the rhomboid protease RHBDL2, which is required for it to encounter available synaptic adhesion proteins. Without this process, excitatory synapses fail to remodel.
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Fromme Lab @fromme-lab.bsky.social · 16/09/2026
Come be our colleague!
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eLife @elife.bsky.social · 15/09/2026
DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2, and -3
buff.ly
DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2, and -3
All three kinesin transport families exhibit unexpectedly slow dissociation under load, explaining robust competition with dynein during bidirectional cargo transport.
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Jessica Cross @jessicacross.bsky.social · 16/09/2026
🚨 Applications open until 21 Sept! We're recruiting a Research Associate/Senior Research Associate in Intracellular Transport & Protein Design at Bristol. 🧬 Protein design, biophysics & cell biology 🌟 3-year Wellcome-funded post Lab: jesscrosslab.org Apply: lnkd.in/emhyYzjT
jesscrosslab.org
Jess Cross Lab
Engineering Biology lab at the University of Bristol
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Sjors Scheres @sjorsscheres.bsky.social · 15/09/2026
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...
nature.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
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Massimo (mirror) @rainmaker1973-m.bsky.social · 14/09/2026
Single-cell manipulation with laser-powered microbots using elastic nanorods and laser tweezers. [🔬 Szeged Institute of Biophysics, Hungary] Original post
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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 14/09/2026
⏰⏰⏰ Less than 2 weeks to submit your Lister Prize 2027 application. Deadline: Midnight, 28 September 2026. lister-institute.org.uk/research-pri...
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Tanmay Bharat @tbharat-lab.bsky.social · 11/09/2026
Exciting work by @florianmayer.bsky.social, @buzzbaum.bsky.social and colleagues. Archaea with more than one membrane! cryo-FIB-SEM volume imaging from Andriko von Kügelgen and @zhexinwang.bsky.social.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 11/09/2026
Ready to take the next step in your research career? The LMB is now accepting applications for PhD placements starting in October 2027. Deadline: 08 December 2026 (allow time for reference submission). Discover what we offer here: mrclmb.ac.uk/careers-and-people/phd…
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Matthew Freeman @mjafreeman.bsky.social · 09/09/2026
Less than 2 weeks to apply! If you are looking for early career fellowship sponsorship, consider @dunnschool.bsky.social to launch your independent career Great science, great support and, of course, lovely colleagues... www.path.ox.ac.uk/work-with-us...
path.ox.ac.uk
Group Leader Career Development Fellowships - Dunn School
Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?
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Niakan Lab @niakanlab.bsky.social · 09/09/2026
Few days left to apply! Please like and share to spread the word!
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Matthew Freeman @mjafreeman.bsky.social · 08/09/2026
Feels like an interesting one... oh, wait...!
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Stefan Luschnig @luschnig.bsky.social · 09/09/2026
Interested in combining #Drosophila genetics, advanced imaging, and modeling to study inter-organ transport and epithelial dynamics? Apply now for #PhD position @uni-muenster.de, integrated in @sfb1348.bsky.social Graduate School. Learn more tinyurl.com/5n86bmsf and tinyurl.com/ypx74a5d
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In Preparation @inprep.bsky.social · 08/09/2026
inpreparation.substack.com
40% Of PhD Now Spent Selecting ‘All Squares Containing Bicycles’
BALTIMORE, MD—A study published Tuesday in PLOS ONE found that approximately 40% of doctoral training is now spent confirming the researcher is not a robot, primarily through the selection of squares…
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Madalena M. Reimão Pinto @madalenamrp.bsky.social · 07/09/2026
Applications for the IMPRS Bio-MAP PhD program now open! 🎉 dipp.cmcb.tu-dresden.de/ausschreibun...
dipp.cmcb.tu-dresden.de
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Lara Krüger @lara-kruger.bsky.social · 09/06/2026
📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.
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The Berro lab @berrolab.bsky.social · 26/08/2026
We are recruiting two experimentalists with interests 1) in stem cells, organoids and/or immune cells, and/or 2) in protein and/or cell engineering, to work on mechanobiology projects and develop the next generation of force sensors and force transducers. forms.gle/zKLGsPzpJoLf...
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Simon Bullock @simonbullock11.bsky.social · 26/08/2026
An exciting opportunity to combine protein design and cytoskeletal transport!👇
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Mary Munson @marymunson4.bsky.social · 26/08/2026
Structural biology postdoctoral position open in my lab--apply now! For more information about the lab, see www.umassmed.edu/munsonlab/. Interested candidates should apply through the University of Massachusetts Chan Medical School jobs portal (www.ummsjobs.com/job/11668/).
umassmed.edu
Munson Lab | Home | BMB | UMass Chan Medical School
The Munson Lab researches the mechanistic basis for the regulation of spatial and temporal specificity in membrane trafficking in the Biochemistry & Molecular Biotechnology Department at UMass Chan Me...
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Jitte @jittebug.nl · 25/08/2026
"Noot noot" #Invertefest
A colorful fly with a weird black-and-white pattern on its wings and abdomen. Its mouthparts are extended like the claymation Pingu character (which commonly says "noot noot")
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Seema Grewal @seemagrewal.bsky.social · 23/08/2026
Join the @jcellsci.bsky.social team! We’re looking for a Reviews Editor to join our editorial team. Details below 👇 Application deadline: 3 September
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Simon Bullock @simonbullock11.bsky.social · 24/08/2026
Fantastic opportunity in a great lab with a great mentor!
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The Dunn School, Oxford @dunnschool.bsky.social · 18/08/2026
There is still 1 month to apply! If you think we might provide the scientific environment you need to launch your independent career, we want to hear from you!
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Helmholtz Institute Würzburg @helmholtz-hiri.bsky.social · 17/08/2026
🧬 @rnamed.bsky.social is hiring! Apply for one of six fully funded #PhD positions in RNA biology and RNA therapeutics, and work with leading RNA experts in an international, interdisciplinary environment. 📅 Application deadline: September 17, 2026 More info: www.helmholtz-hiri.de/en/jobs-tale...
helmholtz-hiri.de
RNAmed - Future Leaders in RNA-based Medicine
RNAmed takes a holistic approach to endow doctoral students with the necessary knowledge and skills in the fast-growing area of RNA-based medicine.
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Lori Passmore @lapassmore.bsky.social · 14/08/2026
Ben Nicholson at the CRUK Cambridge Institute is recruiting a new postdoc to investigate piRNA biology. This is a collaborative project with my group at MRC Laboratory of Molecular Biology (LMB). Interested? Apply or get in touch to discuss! tinyurl.com/y25z8wkn
cam.ac.uk
Postdoctoral Research Associate (piRNA Team) (Fixed Term)
The Cancer Research UK Cambridge Institute is situated on the Biomedical Campus in Cambridge, UK. As part of the University of Cambridge, the institute's research ranges from basic biology through tra...
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Kashish Singh @kashishsingh.bsky.social · 13/08/2026
Very happy to see the final version of our work on the structure and composition of cytoplasmic lattices in mouse embryos, previously shared on bioRxiv, now published in The EMBO Journal! Many thanks to our editor, Ieva Gailite, and the reviewers for their constructive input.
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Matthew Taliaferro @jmtali.bsky.social · 12/08/2026
Excited to share our newest work! We asked whether RNA molecules need to be in a specific place in the cell to do their job. We found that a single RNA must reach the midbody, the structure that pinches two dividing cells apart, for cell division to finish efficiently. 🧵⬇️
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Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
jobs.york.ac.uk
Jobs - The University of York
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PLOS Biology @plosbiology.org · 10/08/2026
During #embryogenesis, anterior-posterior axis formation depends on #chromatin accessibility, but axis determinants are species-specific. This study reveals complex temporal patterns of chromatin accessibility during axis specification in the moth fly. 🧪 #AcademicSky #development plos.io/4hewogE
An image of a moth fly embryo with different patterning determinants creating a color gradient along the anterior-posterior axis.
Flies (Diptera) have evolved many kinds of anterior determinants to specify the primary body axis but so far only the mechanism of action of one, Bicoid, has been characterized in the fruit fly Drosophila melanogaster. Ezra Amiri, Muzi Li, Shelby Blythe, Urs Schmidt-Ott and co-workers find that the anterior determinant of the moth fly Clogmia albipunctata, which is encoded by the zic family member odd-paired, initiates anterior patterning by opening chromatin and activating transcription at Clogmia’s homeobrain (blue) and sloppy-paired (purple and yellow) loci.
Image credit: Maxwell Devine

The authors confirm that this image can be used under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 07/08/2026
Magdalena Sutcliffe, @lancasterlab.bsky.social & @stefanschoenfelder.bsky.social demonstrate how epigenetic ‘memory’ shapes stem cell potential, but a chemical reset can restore differentiation ability. Read more: shorturl.at/PZ4tV #LMBResearch @cellbiol-mrclmb.bsky.social @babrahaminst.bsky.social🧪
Human pluripotent stem cells favour either anterior or posterior formation, but this can be mediated by chromatin restoration (CHR) treatment.Fluorescent micrograph of an organoid with intricate folds and patterns in blue and purple
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Journal of Cell Science @jcellsci.bsky.social · 07/08/2026
We’re looking for a Reviews Editor to join the team. Joining an experienced & successful journal team, this is an exciting opportunity for a talented scientific editor to make a significant contribution to an important journal in the field of cell biology. www.biologists.com/about-us/wor...
biologists.com
Work for us
Explore career opportunities at The Company of Biologists. Join a team passionate about science, publishing and community support.
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Kat Toropova @kattoropova.bsky.social · 16/07/2026
This is a fantastic opportunity, I started my lab through this scheme and the support throughout is phenomenal, please share.
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Simon Bullock @simonbullock11.bsky.social · 21/07/2026
The winners of our school microscopy competition for this year have been announced. Thank you to all the team, and especially Molly Magarotto for all her hard work coordinating the project! mrclmb.ac.uk/news-events/...
mrclmb.ac.uk
A catalyst for curiosity: the 2026 Microscopes 4 Schools Competition sparks students’ scientific intrigue | MRC Laboratory of Molecular Biology
Over 600 students across Cambridge, Peterborough and Bedfordshire took part in the 2026 Microscopes 4 Schools Competition, unlocking a new thirst for scient ...
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Simon Bullock @simonbullock11.bsky.social · 06/07/2026
Great news, Manu! And very thoroughly deserved!
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Matthew Taliaferro @jmtali.bsky.social · 11/06/2026
2/ This study was led by Charlie Moffatt, who just earned their PhD from our lab based in part on this work. @CUAnschutz ⭐️ Preprint here: www.biorxiv.org/content/10.6...
biorxiv.org
Robust mammalian RNA localization elements are complex and multipartite
The subcellular localization patterns of RNAs are controlled by regulatory elements contained within them. However, for most localized RNAs, the identities of these elements remain unknown. We had pre...
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Journal of Cell Biology @jcb.org · 05/06/2026
Design principles of human membrane protein topology. New study from Haoxi Wu @ox.ac.uk and Ramanujan S Hegde @mrclmb.ac.uk: rupress.org/jcb/article/... #membrane #lipid
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