This EMBO Workshop focuses on development, degeneration, and repair of the nervous system across lifespan. These three fields of neurobiology have greatly expanded over the last years, with exciting …

Nature Reviews Neurology, Published online: 29 September 2026; doi:10.1038/s41582-026-01262-3Exploration of the underlying genetic causes of neurodegenerative disorders has revealed defects in endolysosomal pathways as crucial contributors to neuronal dysfunction and death. This Review provides an overview of mechanisms of lysosomal dysfunction in neurodegenerative disease, focusing particularly on Parkinson disease, Alzheimer disease, frontotemporal dementia and amyotrophic lateral sclerosis.

Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

Compartmentalisation enables cells to spatially organise essential biochemical processes. This is exemplified by the eukaryotic nucleolus, which concentrates the machinery for ribosome biogenesis. Bac...

In the nervous system, aging causes deterioration of cellular and molecular processes that are associated with declines in cognition, sensory perception, and motor coordination. Aging is also the strongest risk factor for neurodegenerative disease, yet the mechanisms by which aging predisposes neurons to dysfunction remain incompletely understood. While genomic instability, proteostasis decline, mitochondrial dysfunction, and chronic inflammation have dominated prevailing models, recent evidence highlights RNA dysregulation as a central component of age-associated decline. In this review, we summarize recent findings suggesting that aging progressively erodes RNA regulatory fidelity through alterations in RNA-binding protein abundance, localization, biophysical behavior, and RNA interactions. We argue that age-dependent RNA dysregulation represents an important mechanism that converges with genetic risk to drive neuronal vulnerability and neurodegeneration.

STARFISH, a method for visualizing endogenous mRNA translation, is used to show that tau is translated exclusively in neuronal dendrites and rapidly degraded by neuroproteasomes. Failure of this degra...

This Review discusses the spatial organization of nucleotide metabolism and its integration with cellular signalling pathways, emphasizing its importance as a dynamic regulatory axis in both physiolog...

Bacterial ribosomes can synthesize proteins encoded within their own RNA.

RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.

As a university student working towards my bachelor’s degree, I didn’t even know what it would mean to add “Dr.” to my name. Six months into my postdoc, I

Mammalian oocytes undergo an extended growth phase, during which transcription gradually declines. To sustain meiotic divisions and early embryonic development, growing oocytes must accumulate materna...

Nuclear speckles are prominent biomolecular condensates enriched in RNA-processing factors. Although historically viewed as reservoirs for spliceosoma…

This Roadmap clarifies terminology, core physics, biological roles, and key theoretical, computational, and experimental challenges to guide a coordinated effort toward a predictive understanding and ...

By ruthlessly narrowing down his priorities, Zachary Sentell managed to publish several papers in the final year of his PhD and graduate on time.

In this perspective, Haidar et al. discuss the emerging function of cytoplasmic RNP condensates in translation. The perspective highlights the dual role of condensates in translational repression and activation and the biophysical properties allowing these two functions. It further proposes future directions for decoding the functional compartmentalization of condensates.

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Nature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01008-5MBS1 condensates induced by high light conditions shield chloroplasts and prevent accumulation of singlet oxygen, thereby conferring tolerance without reduction in photosynthesis.

Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

A new study from Carnegie Mellon University identifies a mechanism that controls how cell condensate patterns form and how they play a key role in a cell’s function.

Scientific database for biomolecular condensates research

Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how sho...

This Review discusses how long noncoding RNAs (lncRNAs) control transcription activation by RNA polymerase II, including how they are produced at active enhancers or chromatin-domain boundaries and ac...

Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle conden...

He et al. identify a central regulator of condensate size and dynamics in the Chlamydomonas CO2-fixing condensate, the pyrenoid. KEY1 phosphorylates EPYC1, a linker protein for Rubisco, to maintain py...

LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...

The Institute for Digital Molecular Analytics and Science (IDMxS), officially launched on 1 December 2022, is a Research Centre of Excellence (RCE) supported by a total investment of around S$160 mill...

The deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.

RNA-binding proteins (RBPs) constitute a diverse class of proteins essential for every stage of the gene expression process. Many RBPs are also linked to human diseases and pathologies. Understandi...

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding proteins engage their targets in living cells. This approach quantifies the binding strength of protein-RNA...

RNA-binding proteins (RBPs) are best known as effectors along the entire gene expression pathway and as constituents of RNA-protein machines such as t…

Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

Interview with Omaya Dudin, who uses Ichthyosporea as models to study how and why unicellular organisms evolved multicellularity at the University of Geneva.