Nature Protocols - An approach for combining expansion microscopy with fluctuation-based super-resolution analysis enables the visualization of individual proteins via conventional fluorescence...

An approach for combining expansion microscopy with fluctuation-based super-resolution analysis enables the visualization of individual proteins via conventional fluorescence microscopy.

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Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light microscopy.

From cells to amino acids: 1000ExM pushes expansion microscopy beyond 1000×, potentially resolving individual protein residues on standard microscopes. Bigger volume expansion opens a new frontier for...

𝗘𝘅𝗽𝗮𝗻𝘀𝗶𝗼𝗻 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆 physically enlarges the sample, but it also dilutes fluorophores, exposes them to harsh chemistry, and leaves them in a water-rich gel. Not every dye survives that. Ali Shaib and...

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