Nuclear speckles are “hot”, but how do they actually sequester mRNPs?
We find that stalled mRNPs are retained in nuclear speckles by a combinatorial RNA-binding protein network.
www.biorxiv.org/content/10.6...
biorxiv.org
A combinatorial pre-mRNP retention factor network couples nuclear speckle architecture to splicing quality control
Cells must prevent incompletely spliced transcripts from entering the cytoplasm, yet how splicing status is recognized and converted into selective nuclear retention remains unclear. Here, we identify...
