iiinova — where your digital self keeps evolving

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 29/09/2026

IDPSeminars is BACK this week! 1 pm EST on Thursday! Sign up at idpseminars.com!

Giulio Tesei (Malmö University): Coarse-grained modeling of IDRs from solution to membrane interfaces

Rob Best (NIH): Dissecting the dynamics of bimolecular condensates via molecular simulation

095

Reposted by Alex Holehouse

Biophysical Journal @biophysj.bsky.social · 23/09/2026

Special issue call for papers: Fifty Years of Protein Dynamics: Celebrating Andy McCammon and the Evolution of Computational Biophysics. buff.ly/JcBPrrO

biophysics.org

https://www.biophysics.org/Portals/0/BPSAssets/Publications/Documents/BJ_CallForPapers_ProteinDynamics.pdf#Page=1

053

Reposted by Alex Holehouse

Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 14/09/2026

Happy to share our preprint on a subset of ZBTB BTB domains as highly efficient natural SUMO 'supersubstrates'. The work was spearheaded by a great postdoc, El Hadji Cisse, with input from other team members and in collaboration with @defossezlab.bsky.social and @ucagne.bsky.social

biorxiv.org

A new class of inherently efficient SUMOylation substrates

SUMOylation is an essential eukaryotic ubiquitin-like post-translational modification that plays a central role in the regulation of various nuclear processes and stress responses. It canonically occu...

33720

Reposted by Alex Holehouse

Carl T. Bergstrom @carlbergstrom.com · 13/09/2026

An Iranian friend told me about their sorrow when American bombs fell on their universities. But then, my friend explained, they looked at what was happening to US universities—and realized they got off easy by comparison.

626578

Reposted by Alex Holehouse

WALIIAnhydro @waliianhydro.bsky.social · 09/09/2026

Abstract submissions are OPEN! Share your research at the 2nd Annual WALII Virtual Symposium and connect with researchers exploring anhydrobiosis and desiccation tolerance. Deadline: October 9, 2026 Submit your abstract: bit.ly/4xkAOqL

Promotional graphic for the 2nd AnnualWALII Symposium, “Exploring Life Without Water,” featuring a desert landscape. The graphic provides abstract submission guidelines, including a one-page PDF or Word document with title, authors, affiliation, and abstract. Submission deadline is October 9, 2026.

134

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 25/08/2026

IDPSeminars is BACK for its 22nd season (!!). A fantastic new line up of speakers for Sept/Oct/Nov/Dec! Register at idpseminars.com. First seminar NEXT WEEK (Sept 3rd!) at 10 AM Pacific/1 PM Eastern/ 7 PM EU!

IDPSeminars Season 22 speakers:

Thursday Sept 3rd at noon central USA
Tianjin Yang (National University of Singapore)
Yifan Dai (Washington University in St. Louis)

Thursday Oct 1st at noon central USA
Giulio Tesei (Malmö University)
Rob Best (NIH)

Thursday Nov. 5th at noon central USA
Timothee Lionnet (NYU)
Nicole DelRosso (UCSF)

Thursday Dec 3rd at noon central USA
Margaux Pinney (UCSF)
Iva Pritišanac (Helmholtz Munich)

076

Reposted by Alex Holehouse

Giulio Tesei @giuliotesei.bsky.social · 18/08/2026

Happy to share our new preprint on MEM-CALVADOS! Work led by @rsaltutti.bsky.social extending CALVADOS to flexible proteins at lipid membrane interfaces. 🗞️ doi.org/10.64898/202... 🖥️ github.com/gitesei/MEM-... @vetenskapsradet.bsky.social

Schematic showing the combination of CALVADOS with a coarse-grained lipid model, resulting in MEM-CALVADOS, illustrated using T-cell signaling proteins LAT (cyan), Grb2 (blue), and Sos1 PRR (orange).

03710

Reposted by Alex Holehouse

WALIIAnhydro @waliianhydro.bsky.social · 07/08/2026

Mark your calendars!! We are excited to announce the date for this year's WALII Virtual Symposium on November 12, 2026! More details will be shared soon!

A 'Save the Date' graphic for the 2nd annual WALII Symposium. The text is on a brown square background over an image or dry, cracked mud and water.

176

Reposted by Alex Holehouse

Gladfelter Lab @gladfelterlab.bsky.social · 26/07/2026

You're probably already doing science advocacy — you just might not call it that. Our new commentary (www.nature.com/articles/s41...) makes the case that every scientist has a role, and that advocacy takes many forms. Find and embrace yours! @natcellbio.nature.com @vfarm15.bsky.social

nature.com

Every scientist has a role in advocacy - Nature Cell Biology

In this Comment, we call on scientists to share their stories. Through casual conversation or prepared presentations, with images or essays, scientists can advocate for their research and reach taxpay...

04724

Reposted by Alex Holehouse

Derek Lowe @dereklowe.bsky.social · 23/07/2026

Thoughts on the various Trump administration proposals to revamp US science funding - and what they all have in common:

science.org

The Assault On Science Funding Continues

3309155

Reposted by Alex Holehouse

Ed Burmila @edburmila.bsky.social · 04/07/2026

Turns out “America 250” was a temperature forecast

14935169

Reposted by Alex Holehouse

idpgrc.bsky.social @idpgrc.bsky.social · 27/06/2026

And the poster award winners: Christopher Reinkemeier (ETH) Guo-Teng Liang (Baylor) Jeff Lotthammer (WashU) Jake Simmons (UNC) Sean Carney (NIH) Nazanin Farahi (VIB) Sveinn Bjarnason (Uni. Iceland) Carla Garcia Cabau (IRB) Carlos A. Elena-Real (FMP) Marissa Zintel (Berkeley)

072

Reposted by Alex Holehouse

Itai Yanai @itaiyanai.bsky.social · 20/06/2026

Unpopular opinion: Going straight to AI limits your creatively, because it short-circuits the iterative process you need to develop new ideas.

69512

Alex Holehouse @alexholehouse.bsky.social · 13/06/2026

I’ll take “headlines that would have had you committed” for 100

BBC article with the headline: Why is Trump hosting a cage fight at the White House?

https://www.bbc.co.uk/news/resources/idt-c3a45322-cba2-468a-931c-24ec24b74a38

070

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 02/06/2026

IDPSeminars is back for a final seminar of spring 2026! This week, we welcome Wenwei Zheng and Sigrid Milles! The seminar is at 10 AM PST / 1 pm EST / 7 PM European time on Thursday. Sign up via our website at idpseminars.com!

Wenwei Zheng (Arizona State University): "Structural Organization of Intrinsically Disordered Protein Ensembles"

Sigrid Milles (FMP Berlin): "How disorder regulates endocytosis: dynamics across molecular scales"

0126

Reposted by Alex Holehouse

Beau @drbeaubeaumont.bsky.social · 24/05/2026

Aston Virra’s Orrie Wartkins:

031

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 06/05/2026

IDPSeminars is back TOMORROW (Thursday May 7th)! Come see Matt Parker and Maria Hondele speak! 1 pm EST / 7 pm EU - sign up with the link from our homepage idpseminars.com

IDPSeminar talks from two speakers:

1. Matt Parker (UTSW Medical Center); Rapid evolution of DNA replication origin selection mechanisms

2. Maria Hondele (University of Basel): DEAD-box ATPases as adaptive organizers of RNA condensates from bacteria to eukaryotes.

144

Reposted by Alex Holehouse

Paul Robustelli @paulrobustelli.bsky.social · 08/04/2026

The Robustelli laboratory is hiring a Postbaccalaureate Fellow to work in the group for 1 year with a focus on either experimental or computational biophysics! apply.interfolio.com/184353 This position is ideal for students seeking experience before applying to a PhD program.

apply.interfolio.com

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

164

Reposted by Alex Holehouse

Cameron Blevins @cblevins.bsky.social · 03/04/2026

This is so, so well-articulated.

People call this friction "grunt work." Schwartz uses exactly that phrase, and he's right that LLMs can remove it. What he doesn't say, because he already has decades of hard-won intuition and doesn't need the grunt work anymore, is that for someone who doesn't yet have that intuition, the grunt work is the work. The boring parts and the important parts are tangled together in a way that you can't separate in advance. You don't know which afternoon of debugging was the one that taught you something fundamental about your data until three years later, when you're working on a completely different problem and the insight surfaces. Serendipity doesn't come from efficiency. It comes from spending time in the space where the problem lives, getting your hands dirty, making mistakes that nobody asked you to make and learning things nobody assigned you to learn.

97107603880

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 02/04/2026

IDPSeminars back TOMORROW (Thursday, April 2nd)! Sign up here: idpseminars.com Seminar at 10 am PST/ 1 pm EST / 7 pm CEST

Min Kyung Shinn (King's College London): Multi-domain splicing factors in the nuclear speckles undergo microphase separation

Hugo Sanabria (Clemson University): IDR-mediated control of supertertiary structural ensembles

042

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 28/03/2026

IDPSeminars is BACK for a new season! Six new speakers in April, May, and June! First talk next week! Tell your friends!

Speaker information for IDPSeminars Season 21
April 2nd: Min Kyung Shinn (Kings, UK) and Hugo Sanabria, Clemson USA
May 7th: Matt Parker (UTSW, USA) and Maria Hondele (Basel)
June 4th: Wenwei Zheng (ASU USA) and Sigrid Milles (FMP, Berlin)

1196

Reposted by Alex Holehouse

Derek Lowe @dereklowe.bsky.social · 25/03/2026

How do the "death fold domain" proteins in the innate immune system react so quickly and thoroughly, but without needing any driving energy like ATP? A weird but quite believable answer:

science.org

Set Phasers to

13712

Reposted by Alex Holehouse

Davide Mercadante @mercadantelab.bsky.social · 19/03/2026

Now published in JACS🚨!! We introduce Martini3-NMR: a framework that can incorporate NMR observables directly into coarse-grained Martini models. This enables experimentally driven, high-efficiency & high-accuracy simulations in the wake of integrative biophysics! pubs.acs.org/doi/10.1021/...

pubs.acs.org

Integrating NMR Restraints into Coarse-Grained Simulations: Toward Accurate Conformational Ensembles of Complex Protein Systems

Structural dynamics play critical roles for the biological activity of protein molecules. Characterizing the inherent conformational landscapes of these macromolecules remains a major experimental and...

1209

Reposted by Alex Holehouse

Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 06/03/2026

The Protein Data Bank (#PDB) has reached a new milestone: 250,441 entries in the archive, a record since its founding in 1971, all thanks to the efforts and contributions of the structural biology community. ⬇️ more ⬇️ www.wwpdb.org/news/news?ye... #StructuralBiology

0198

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 04/03/2026

IDPSeminars is back TOMORROW! Come see @tanjamittag.bsky.social and @xsalvatella1.bsky.social ! Not to be missed!!

0198

Alex Holehouse @alexholehouse.bsky.social · 27/02/2026

New (well, very old, but 100% updated) preprint: Rational design of disordered proteins for systematic sequence-to-function investigation Work done in collaboration with @shaharsu.bsky.social lab - check out the three (3) threads from the folks who did the work!

192

Reposted by Alex Holehouse

Jerelle Joseph @jerelleaj.bsky.social · 24/02/2026

On the cover of #JCP, Pablo’s work on “Condensate Deborah Numbers” pubs.aip.org/aip/jcp/arti...

1234

Alex Holehouse @alexholehouse.bsky.social · 22/02/2026

Sad to miss my first Biophysical Society Meeting in 12 years, but the lab will have strong representation! A thread (1/7)

2111

Alex Holehouse @alexholehouse.bsky.social · 19/02/2026

Papers are like buses... You wait for ages, then two come along at once. Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published! www.nature.com/articles/s41...

nature.com

Accurate predictions of disordered protein ensembles with STARLING - Nature

The deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.

69036

Reposted by Alex Holehouse

Jerelle Joseph @jerelleaj.bsky.social · 07/02/2026

Many condensates can be described as active soft materials that generate molecular fluxes. Here we develop a new #nonequilibrium approach (TRACE) to study molecular transport through condensates! Work led by Yashraj Wani!! www.biorxiv.org/content/10.6...

biorxiv.org

1187

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 04/02/2026

IDPSeminas is back again TOMORROW! Talks from Lucia Strader (@luciastrader.bsky.social) and Heather Meyer! Sign up at idpseminars.com. Talks start at 1 pm EST / 7 PM CET!! Come learn about transcriptional adaptation and IDRs as environmental sensors and accuators!

Poster showing program for IDPSeminars on Feb 5th. Talks are:

Lucia Strader: IDR sequence features of activation domains
Heather Meyer: IDPs as environmental sensors and actuators in plants

185

Reposted by Alex Holehouse

EMBL Events @events.embl.org · 02/02/2026

Last chance to submit your abstract for 'Cellular mechanisms driven by phase separation'! Let's tackle emerging questions in cellular organisation, adaptation, and robustness together 🧬🦠 #EESPhaseSeparation 19 – 22 May 2026 Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl

1106

Reposted by Alex Holehouse

Karolina Heyduk @kheyduk.bsky.social · 23/01/2026

Me: Hey Outlook can you attach this file. Outlook: No, I'm now crashing out. Me: OK but can you show me this calendar invite? Outlook: Also no. It has been mysteriously deleted. Me: What can you do? Outlook: I definitely cannot effectively search your emails.

1112

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 06/01/2026

IDPSeminars is BACK THIS WEEK! Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time! Sign up here: forms.gle/3yCHeYvuuqLh... And check out the full Spring 2026 schedule at idpseminars.com!

Seminar titles: Andrea Soranno (Single molecule spectroscopy of
disordered regions and nucleic acids) and Bokai Zhu (Nuclear speckle rejuvenation to ameliorate proteinopathy).

0108

Alex Holehouse @alexholehouse.bsky.social · 24/12/2025

“So is it cold in St. Louis during the winter, or does it stay pretty warm?” Yes.

Screenshot of weather transitioning from 61 F to 20 F in’s ~12 hours

1110

Reposted by Alex Holehouse

Alex Bisson @archaeon-alex.bsky.social · 24/12/2025

I am beyond excited to announce that the Bisson Lab has a new home!!! Starting January 2026, I will join the Biology Department at Indiana University Bloomington as Associate Professor with tenure. I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join [1/4]

2019125

Alex Holehouse @alexholehouse.bsky.social · 22/12/2025

WorkDay is the hardest, most complex puzzle game I've ever played. Graphics are terrible, gameplay is clunky, characters are numerous but never actually useful or interesting, but the difficulty is 11/10. Truly l33t.

2100

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 12/12/2025

The @biophysicalsoc.bsky.social IDP Subgroup Postdoctoral Award honors outstanding Postdoctoral Fellows for their research accomplishments. APPLY by sending your nomination packet to idpsubgroupbps@gmail.com by Dec 15th! Find all information at: www.biophysics.org/awards-fundi...

biophysics.org

Subgroup Awards - The Biophysical Society

076

Reposted by Alex Holehouse

Terry McGlynn @hormiga.bsky.social · 11/12/2025

You can do this right now: Think of a person who wrote a paper you love, whose work influenced or helped you, or has made your professional life better. Search up their email address. Shoot them a quick email of thanks. It means so, so much. This is a rough time of year, share some joy.

13699260

Reposted by Alex Holehouse

IDPSeminars @idpseminars.bsky.social · 01/12/2025

We're back for our final seminar of 2025 with talks from @alexholehouse.bsky.social and Birthe Kragelund! 1 pm EST or 7 pm European time. If you're not already signed up, head on over to idpseminars.com to register!

Talk titles for IDPSeminars on Dec 4th at noon central time.

Alex Holehouse (Washington University in St. Louis): Sequence-to-ensemble with STARLING

Birthe Kragelund (University of Copenhagen): Disordered protein complexes and the origins of life

01512

Alex Holehouse @alexholehouse.bsky.social · 01/12/2025

Love this; inspired by early experiences and cemented by the incomparable @jiwasa.bsky.social at an incredible workshop she and @theroglab.bsky.social organized in '22, I've become thoroughly convinced that - at least for me - developing figures from scratch is a key part of scientific inquiry.

0122

Alex Holehouse @alexholehouse.bsky.social · 21/11/2025

Brief interruption to science: For the four folks reading this who may be interested, death metal band Emperor is touring the US next spring. If you care, you care 🤘.

060