Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how sho...

A nascent group of researchers sees planetary health as an urgent reason to bridge the molecular and planetary scales. This is shaping their strategies, methods, collaborations and outlook about their...

In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent studies have now rev...

N6-methyladenosine (m6A) is a critical regulator of mRNA processing and function, impacting nearly every step of the mRNA lifecycle. Changes in m6A status have been implicated in many different types ...

A Yale study published Aug. 28 on the cover of the journal Blood explains basic scientific discoveries that could lead to innovative therapies for acute myeloid