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Carmelo Ferrai

@carmeloferrai.bsky.social
3.1K followers 941 following 1.3K posts

RNAPII &Transcription Regulation -Chromatin Conformation & Nuclear Architecture - ESCs & Neuronal Differentiation - Nuclear Mechanotransduction - Cell Plasticity UMG, Göttingen, Germany

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Carmelo Ferrai @carmeloferrai.bsky.social · 24/09/2026
Confocal image of a MSC upon sonostimulation.
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Carmelo Ferrai @carmeloferrai.bsky.social · 16/09/2026
EpiSci
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Giacomo Donati @giacomodonatijd.bsky.social · 11/08/2026
The final version is now online! #RNALocalization #Chromatin #FunctionalGenomics #CellMigration #CancerBiology www.nature.com/articles/s41...
nature.com
Multilayered control of mRNA delivery to cell protrusions drives localized mini-cytoplasm establishment for stress-induced cell activation - Nature Communications
Here the authors show that, under stress, epithelial cells reveal an unexpected role for a chromatin factor in directing mRNA to cell protrusions, enabling local organelle assembly and cell movement, ...
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Carmelo Ferrai @carmeloferrai.bsky.social · 26/08/2026
Migratory Egg…
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Carmelo Ferrai @carmeloferrai.bsky.social · 26/08/2026
Prof. Jacopo Meldolesi passed away. He was a great teacher and a lovely person with an extraordinary passion for neuroscience to which he tirelessy dedicated his life. Farewell Jacopo it was a privilege knowing you and sharing with you a few steps on the journey of scientific discovery. RIP Jacopo
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Simon Stitzinger @simonstitzinger.bsky.social · 11/06/2025
Are you in Freiburg and interested in biophysics? Remember to sign up for the Biophysical Coffee ☕ Meeting Freiburg, only a few days are left! Talks and Posters will be selected from registered participants. Participation is free, but registration is required. www.ie-freiburg.mpg.de/events/41674...
ie-freiburg.mpg.de
1st Biophysical Coffee Meeting Freiburg
To enhance the exchange and interaction among people working on biophysics in Freiburg, we are organizing the Biophysical Coffee Meeting Freiburg, which will take place on July 4, 2025 at the Max Plan...
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Simon Stitzinger @simonstitzinger.bsky.social · 24/08/2026
Dear Freiburg Biophysics community, We are happy to announce the 2026 Biophysical Coffee Meeting Freiburg on October 02, 2026! There will be talks, posters, and plenty of time for discussion and to exchange ideas. Please sign up here: register.ie-freiburg.mpg.de/event/26
Poster for the 2026 Biophysical Coffee Meeting Freiburg
02 October, 2026
University Freiburg
Chemistry Flachbau
starting at 14:00
Albertstr. 21, R 00 002
submit abstract until 11 September, 2026
register.ie-freiburg.mpg.de/event/26
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Jean-Paul Armache @valendraica.bsky.social · 08/07/2026
If you or someone you know is interested in joining a fun and productive lab (JP Armache laboratory at Penn State University) to work on exciting projects, please follow or share the link below. psu.wd1.myworkdayjobs.com/PSU_Academic...
psu.wd1.myworkdayjobs.com
Postdoctoral Position
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
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Sara Luzzi @saraluzzi.bsky.social · 16/07/2025
Don't miss your chance to register and send your abstract!
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Sara Luzzi @saraluzzi.bsky.social · 11/08/2026
🧬 𝐓𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐂𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐔𝐊 𝟐𝟎𝟐𝟔 🧬 Join us in York 18–20 November! We have an exciting program, presentation opportunities available and super-early booking discounts if you register by 18th August! More information here: www.eventsforce.net/biochemsoc/f...
eventsforce.net
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Carmelo Ferrai @carmeloferrai.bsky.social · 12/08/2026
🤩
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Carmelo Ferrai @carmeloferrai.bsky.social · 11/08/2026
Mega-enhancers compartmentalize transcriptionally active long genes in the brain www.nature.com/articles/s41...
nature.com
Mega-enhancers compartmentalize transcriptionally active long genes in the brain - Nature Cell Biology
Zhao et al. describe an enhancer-dense nuclear microenvironment in the cerebellum that includes long neuronal genes and mega-enhancers. This microenvironment partly depends on the transcription factor...
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Mathis Riehle @mornorse.bsky.social · 23/07/2026
Last week I attended the 6th 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 𝗼𝗻 𝗠𝗲𝗰𝗵𝗮𝗻𝗼𝗯𝗶𝗼𝗹𝗼𝗴𝘆 #ISMB2026 that was organised as part of SynSci — Synergy for Science 2026 and did some #Sketchnotes along the way; I plan to add the missing ones with time… bio-mat-sketches-mor.blogspot.com/2026/07/2026...
bio-mat-sketches-mor.blogspot.com
2026 International Society for Mechanobiology meeting in Glasgow at SynSci
A visual blog about science and tissue engineering. Based on live doodles/sketchnotes done during talks. Some with an abstract/writeup.
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Journal of Cell Science @jcellsci.bsky.social · 13/07/2026
Chonkit Lio, Yuexia Wang, Paige Wilson, Howard Worman, Wakam Chang, Gregg Gundersen & team find that farnesylated prelamin A variants associated with premature aging disorders disrupt mobility of LINC complex proteins leading to defects in polarity. journals.biologists.com/jcs/article/...
Figure showing nuclear positioning and centrosome orientation in prelamin A-expressing cells treated with shRNA against SUN1 or the dynein inhibitor HPI-4.
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Carmelo Ferrai @carmeloferrai.bsky.social · 13/07/2026
@xaviertrepat.bsky.social rocking the stage here at the SynSci — Synergy for Science 2026 awesome mechano-biology data in defining cell patterning
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Warmflash lab @warmflashlab.bsky.social · 18/05/2026
My lab is hiring! We have an open postdoc position to study the endometrial-embryo interface using organoids, embryo models, and live imaging. Reach out or apply: bit.ly/4duGA0P
bit.ly
Postdoctoral Research Fellow (Warmflash) Stem Cell Biology
We are seeking a postdoctoral researcher to join an interdisciplinary project focused on the biology of embryo implantation. The position centers on understanding how the endometrium and early embryo ...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 05/07/2026
Multi-ciliated cells drive many key events, including, for example, expelling pathogens and debris from our lung airways. @raghavan-thiaga.bsky.social Provides a great introduction to the cell biology behind this, and the many unanswered questions. Plus lovely images!! Check it out. 🧪
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James Briscoe @jamesbriscoe.bsky.social · 02/07/2026
Paying peer reviewers Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review Spoiler: it works - fast, high quality reviews www.nature.com/articles/d41...
nature.com
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
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Craig Kaplan @triggerloop.bsky.social · 29/06/2026
The Kaplan Lab at the University of Pittsburgh has received funds to recruit a postdoctoral fellow to establish a multiplexed assay of variant effect for a disease gene. This relates to our studies on RNA Polymerase II. This project requires experience with human cell lines and genomics 1/
cfopitt.taleo.net
Post Doctoral Associate
Click the link provided to see the complete job description.
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Akis (Argyris) Papantonis @akispapantonis.bsky.social · 27/06/2026
I have spent a long time resisting the use of AI in my everyday task, let alone in the process of scientific production (text, figures, ideas) which is anyway the bit of this weird profession that I enjoy the most. In the ensuing mini-rant, echoing Aydan’s thoughts, I want to highlight few things…
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Teif lab @teiflab.bsky.social · 28/06/2026
1/9 A few thoughts and personal opinions on the use of AI in research evaluation. I suspect many of these changes may be inevitable, so the real question may not be whether this will happen, but how we shape it responsibly 🧵
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Carmelo Ferrai @carmeloferrai.bsky.social · 29/06/2026
RIP Frank Grosveld
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Carmelo Ferrai @carmeloferrai.bsky.social · 28/06/2026
How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. hubs.la/Q04mQjrC0
hubs.la
Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity
Plasma membrane identity depends on tight control of anionic lipid composition, but how cells sense and correct imbalances remains poorly understood. Huang
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Carmelo Ferrai @carmeloferrai.bsky.social · 28/06/2026
Very nice! @mornorse.bsky.social bio-mat-sketches-mor.blogspot.com/2024/11/cars... @carstenschulte4.bsky.social
bio-mat-sketches-mor.blogspot.com
Carsten Schulte: Cellular Mechanobiology in Health & Disease: A Tour de Force
A visual blog about science and tissue engineering. Based on live doodles/sketchnotes done during talks. Some with an abstract/writeup.
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Mathis Riehle @mornorse.bsky.social · 21/03/2025
Hi - I draw along talks for a hobby - making #sketchnotes, mainly #science, sometimes #politics that I publish on my blog: bio-mat-sketches-mor.blogspot.com
bio-mat-sketches-mor.blogspot.com
TalksAsDoodles
A visual blog about science and tissue engineering. Based on live doodles/sketchnotes done during talks. Some with an abstract/writeup.
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Journal of Cell Science @jcellsci.bsky.social · 25/06/2026
Our Special Issue: Cell Biology of the Nucleus has been building over the last few months. In the coming weeks, we’ll be highlighting all the articles in this issue. First up, we have an interview with our Guest Editor @abbybuch.bsky.social: journals.biologists.com/jcs/article/... #CellBio #nucleus
Abby Buchwalter
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Abby Buchwalter @abbybuch.bsky.social · 21/06/2026
After some good funding news, we are hiring! Looking for a postdoc to join our team and lead our explorations into transposon repression by the nuclear lamina. Check out the full ad on our lab website at buchwalter-lab.github.io/postdoc-ad.pdf + contact me to learn more!
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Ruben Gonzalez @rubenlgonzalez.bsky.social · 24/06/2026
Preprint alert! Using smFRET, we define the only essential ATP hydrolysis step in translation initiation. We show that eIF3 and eIF4B stimulate ATP-hydrolysis-dependent recycling of cap-stalled eIF4F, coupling eIF4F recycling to PIC loading onto an mRNA.🔬 doi.org/10.64898/202...
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MwahahahahahadScientist @mads100tist.bsky.social · 19/06/2026
Registration deadline for Abstracts to be considered for a talk is tomorrow! 🐟 The deadline for the "From Postdoc to PI" will remain open for two more weeks. Come to Heidelberg so we can have fun. There will be prizes! 🧪
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 18/06/2026
Your periodic reminder that the non-profit publisher @biologists.bsky.social funds grants that support meetings in the areas of its journals: @jcellsci.bsky.social @dev-journal.bsky.social @jexpbiol.bsky.social @dmmjournal.bsky.social 1/2 🧪 www.biologists.com/grants/scien...
biologists.com
Scientific Meeting Grants
Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...
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Max Delbrück Center @mdc-berlin.bsky.social · 17/06/2026
Programming and reprogramming living systems take center stage at the #mdcBerlin Bioengineering Symposium 2026. Our speakers will share insights from synthetic biology, immunology, and systems biology. 🗓️ July 6 | Berlin-Buch More info and registration: 👉 www.mdc-berlin.de/BioE-2026 👈

Graphic with background image and text for the Max Delbrück Center Bioengineering Symposium 2026. The image shows a fluorescent microscopy image in blue, green, and red.

The text reads: “Afternoon Session II. Programming and Reprogramming Living Systems. Bioengineering Symposium 2026. 3:30 PM | July 6 | Berlin-Buch.”
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Zebrafish Rock! @zebrafishrock.bsky.social · 17/06/2026
JOB ALERT🚨The Zwaka Group at the Leibniz Institute for Neurobiology in Magdeburg 🇩🇪 is seeking a full-time Postdoctoral Fellow to be a key part of their fishy research team. 🐟💤🧠🫀 More details and how to apply in this thread ⬇️ #ZebrafishJobs #PostdocJobs #zebrafish 🧪 @hannazwaka.bsky.social
ALT text: A group of wild-type zebrafish larvae swimming in a petri dish. Credit to Pradeep Krishna Chintapalli.
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Carmelo Ferrai @carmeloferrai.bsky.social · 16/06/2026
Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation www.cell.com/developmenta...
cell.com
Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation
Zhang et al. develop hPSC-derived pancreatic progenitor organoids that model PDAC initiation and progression. The model reveals that CDKN2A loss is uniquely required for human pancreatic transformatio...
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Lennart Hilbert @lennarthilbert.bsky.social · 14/06/2026
The zebrafish embryo is a great model of stem cell processes: zygotic genome activation and germ layer specification, within a single work day! Similar to mouse embryonic stem cells, we find transcriptional clusters undergo massive, global shifts. advanced.onlinelibrary.wiley.com/doi/10.1002/...
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Carmelo Ferrai @carmeloferrai.bsky.social · 10/06/2026
👇🏽👇🏽👇🏽👇🏽👇🏽
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 15/02/2026
The bumpy road leads to the nucleus--cool new mechanobiology!
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Eran Meshorer @meshorer.bsky.social · 15/02/2026
Extracellular environment stabilization of stem cell state identity via KDM3A👇🔥
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Carsten Schulte @carstenschulte4.bsky.social · 01/05/2026
New PhD opportunity in my lab📣! The PhD studentship* will be embedded in a broader project looking at glioblastoma from a mechanobiological angle, funded by a recently granted Springboard award from the @acmedsci.bsky.social 🙏. *only home student fees covered 👉 www.findaphd.com/phds/project...
findaphd.com
Leveraging mechanobiology for the dissection of stem-like properties and therapeutic resistance potential in glioblastoma cells at University of Strathclyde on FindAPhD.com
PhD Project - Leveraging mechanobiology for the dissection of stem-like properties and therapeutic resistance potential in glioblastoma cells at University of Strathclyde, listed on FindAPhD.com
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Lennart Hilbert @lennarthilbert.bsky.social · 09/06/2026
I will bombard you on bluesky with more material over the next days, no shame.
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Lennart Hilbert @lennarthilbert.bsky.social · 09/06/2026
If you see this image and think "ha, fly testis!", you know your stuff. If you also know how transcription clusters form and disperse during sperm precursor formation, maybe don't read our new Advanced Science paper, out today 😉 advanced.onlinelibrary.wiley.com/doi/10.1002/...
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Carmelo Ferrai @carmeloferrai.bsky.social · 09/06/2026
Hear hear, Another fantastic collaborative project have seen the light! After a few years of backing...the manuscript on how "Stem cell differentiation disperses transcriptional clusters via a conserved surface-condensate trajectory" Is out 🥳🥳 🍾🍾🥂🥂 advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
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Carmelo Ferrai @carmeloferrai.bsky.social · 09/06/2026
Bufalina…
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Carmelo Ferrai @carmeloferrai.bsky.social · 05/06/2026
Check this out! Synergy for Science 2026 event, Glasgow UK 12–16 July 2026 👉For updates: lnkd.in/eYwaRpzd 👉Planning to attend? join the event: iop.eventsair.com/synsci26/ Registrations still open! It would be great seeing many of you there & building something genuinely cross-disciplinary together
iop.eventsair.com
Home - Synergy for Science
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Carmelo Ferrai @carmeloferrai.bsky.social · 31/05/2026
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Carmelo Ferrai @carmeloferrai.bsky.social · 30/05/2026
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Carmelo Ferrai @carmeloferrai.bsky.social · 25/05/2026
Extremely happy that our work has been selected for an oral presentation at the mechanobiology meeting in Glasgow! Looking forward for great scientific discussions on the interplay between mechanoresponse & Chromatin regulation! See U soon Glasgow! iop.eventsair.com/synergy-for-...
iop.eventsair.com
Programme: ISMB - Synergy for Science 2026: ISMB
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Carmelo Ferrai @carmeloferrai.bsky.social · 23/05/2026
😉
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Carmelo Ferrai @carmeloferrai.bsky.social · 22/05/2026
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Elisha Krieg @elishakrieg.bsky.social · 11/09/2025
Exciting application of our programmable #CellCulture matrix #DyNAtrix. By creating a mechanically reconfigurable microenvironment, we can now invert & guide epithelial cell polarity in real time. #DNAnanotech 1/ 🧵
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Carmelo Ferrai @carmeloferrai.bsky.social · 20/05/2026
So nice to see this manuscript published in Nature Communications. Congratulations to all the team that put so much effort into it 👏🏽👏🏽👏🏽. I am very happy that we have been part of it and that we had the opportunity to give our contribution to this great study! www.nature.com/articles/s41...
nature.com
Variant U1 snRNAs contribute to cell cycle and differentiation control of human iPS cells - Nature Communications
Stem cell identity and differentiation require precise gene regulation, yet key regulatory components remain poorly understood. Here, the authors show that variant U1 snRNAs have distinct and essentia...
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