iiinova — where your digital self keeps evolving

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Sukrit Singh @sukritsingh92.bsky.social · 15/09/2026

📣 The Singh Lab opens at Fox Chase Cancer Center in Spring 2027, where I will be starting as an Assistant Professor!📣 Excited to continue studying how protein biophysics shapes drug response. I am hiring across all levels and disciplines! Apply on the "Join" page ( & spread the word!): singhlab.bio

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Jerelle Joseph @jerelleaj.bsky.social · 20/08/2026

Out now in #JACS work led by the talented @nathanieldhess.bsky.social on protein folding inside condensates!! pubs.acs.org/jacsat/artic...

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 21/08/2026

And this on stability of RRMs in condensates bsky.app/profile/lind...

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Nate @nathanieldhess.bsky.social · 21/08/2026

Very excited that our work is now officially published in @jacs.acspublications.org (doi.org/10.1021/jacs...)! I am very grateful to my advisor @jerelleaj.bsky.social, the reviewers, editor, funders, and all the people I've had discussions with on this project over the years!

Biomolecular condensates dictate the folding landscape of protein alpha-helices through multivalent interactions, crowding, and kinetic frustration leading to a dually sequence dependent folding landscape.

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Laboratory of Soft and Living Materials @SoftLiv_Cornell @softliv.bsky.social · 06/08/2026

Our new paper is out! We asked how small molecules influence biomolecular condensation. Our findings help identify molecules and rxns that regulate physiology and inform therapeutic development. Susceptibility and regulation of biomolecular condensates by solutes | PNAS www.pnas.org/doi/10.1073/...

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Gladfelter Lab @gladfelterlab.bsky.social · 26/07/2026

You're probably already doing science advocacy — you just might not call it that. Our new commentary (www.nature.com/articles/s41...) makes the case that every scientist has a role, and that advocacy takes many forms. Find and embrace yours! @natcellbio.nature.com @vfarm15.bsky.social

nature.com

Every scientist has a role in advocacy - Nature Cell Biology

In this Comment, we call on scientists to share their stories. Through casual conversation or prepared presentations, with images or essays, scientists can advocate for their research and reach taxpay...

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Laboratory of Soft and Living Materials @SoftLiv_Cornell @softliv.bsky.social · 01/06/2026

New preprint! 🧪 What happens when phase separation couples to a nematic transition? 🫧 By combining experiment and theory 🔬, we find some pretty wild ternary phase diagrams! 🌈 Congrats on this milestone, Sully! Check it out here. arxiv.org/abs/2605.26338

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Juan C. Landoni @jclandoni.bsky.social · 03/04/2026

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

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xavier salvatella @xsalvatella1.bsky.social · 16/03/2026

Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !

science.org

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule

The druggability of intrinsically disordered regions.

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Gladfelter Lab @gladfelterlab.bsky.social · 08/03/2026

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations. www.nature.com/articles/s41...

nature.com

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology

Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

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Laboratory of Soft and Living Materials @SoftLiv_Cornell @softliv.bsky.social · 28/02/2026

Happy to share our first preprints from work originating at Cornell! Takumi's paper describes how small molecules shift phase equilibria of condensates by focusing on the dilute-phase response. It shows how metabolites may tune stability and material properties. www.biorxiv.org/content/10.6...

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Takumi Matsuzawa @takumimatz.bsky.social · 28/02/2026

Here’s another condensate paper from the lab. We revisit biomolecular condensation—phase separation in protein suspensions—through the lens of critical phenomena. Kaarthik did excellent work characterizing mechanical properties and comparing their scaling behavior to the 3D Ising universality class.

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Laboratory of Soft and Living Materials @SoftLiv_Cornell @softliv.bsky.social · 28/02/2026

Our second Cornell-era preprint is also out! Kaarthik's paper discusses the gap between cellular and in vitro condensates. In cells, condensates are low-contrast (small partition coefficients), enabling a wide range of responses. Congrats, Kaarthik and the team! www.biorxiv.org/content/10.6...

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Jerelle Joseph @jerelleaj.bsky.social · 24/02/2026

On the cover of #JCP, Pablo’s work on “Condensate Deborah Numbers” pubs.aip.org/aip/jcp/arti...

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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 23/02/2026

Partition Coefficients Reveal Changes in Properties of Low-Contrast Biomolecular Condensates www.biorxiv.org/content/10.64898/20…

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Jerelle Joseph @jerelleaj.bsky.social · 07/02/2026

Many condensates can be described as active soft materials that generate molecular fluxes. Here we develop a new #nonequilibrium approach (TRACE) to study molecular transport through condensates! Work led by Yashraj Wani!! www.biorxiv.org/content/10.6...

biorxiv.org

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Jerelle Joseph @jerelleaj.bsky.social · 14/01/2026

How does protein folding change inside biomolecular condensates? Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social

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Nate @nathanieldhess.bsky.social · 14/01/2026

I am very excited to share our pre-print that was just released on the bioRxiv entitled "Biomolecular Condensates Dictate the Folding Landscape of Proteins" doi.org/10.64898/202... Very grateful for @jerelleaj.bsky.social and the members of the Joseph Group for their support on this project! (1/4)

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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 14/01/2026

Biomolecular Condensates Dictate the Folding Landscape of Proteins www.biorxiv.org/content/10.64898/20…

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Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · 23/01/2025

Now online - the Review "Structured protein domains enter the spotlight: modulators of #biomolecularcondensate form and function" from Nathaniel Hess and @jerelleaj.bsky.social. #PhaseSeparation #ProteinProteinInteraction #Oligomerization #ProteinRNAInteraction authors.elsevier.com/sd/article/S...

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