The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

A blog about scientific publishing and academic productivity

PhD Project - Developing a non-coding RNA predictive biomarker in bladder cancer at University of Sheffield, listed on FindAPhD.com

Step 1: Register through our event page. All attendees should register to attend through our event page. Early bird registration deadline is the 17th of July (£35) and late registration deadline is th...

Abstract. CREB-binding protein (CBP) is a histone acetyltransferase and transcriptional co-activator that operates across the genome at cis-regulatory elements (CREs) to regulate gene expression. Comp...

Acetylation of histones and transcriptional regulators modulates gene expression, but how acetyltransferases define target specificity remains puzzling. In Cell Reports, Gelder et al. have shown how i...

Gelder et al. demonstrate that intrinsically disordered regions (IDRs) with divergent sequence properties maintain a functional balance between positive and negative regulation of CBP condensates. This intramolecular mechanism tunes CBP’s sensitivity to lysine acetylation; its disruption fundamentally alters chromatin binding, histone acetylation, and gene expression.