Our new Cell Reports paper is out! CD4 cytotoxic T cells expand in centenarians and supercentenarians, remain responsive, and form large private clones—suggesting active immune remodeling in exceptional aging.
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CD4 CTLs in supercentenarians: Signs of adaptive expansion in healthy aging
Hashimoto et al. show that CD4 CTLs expand around age 100 and form large private clones
without exhaustion. These cells exhibit stepwise differentiation and cytokine plasticity,
suggesting adaptive re...