New in Nature Methods! 🔬🧪Joly et al. profiled intact tau molecules one at a time. Across cell models and brain tissue, they found 130 forms of full-length tau and certain phosphorylation sites that tend to show up together on the same molecule. doi.org/10.1038/s415...
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Large-scale single-molecule analysis of tau proteoforms - Nature Methods
Iterative Mapping of proteoforms enables large-scale measurement of intact proteoforms with single-molecule resolution. The approach is demonstrated here by quantifying tau proteoform groups across co...
