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Ilaria Morella

@ilariamorella.bsky.social
230 followers 344 following 6 posts

Assistant Professor @University of Pavia decoding protein signalling to tackle neurodevelopmental disorders 🧠 | Former post-doc @Cardiff University | Behavioural neuropharmacologist in awe of stem cells 🐭💊🧫 Art galleries wanderer 🖼️| Music lover 🎶

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Reposted by Ilaria Morella
Giovanni D’Angelo @giodang.bsky.social · 23/09/2026
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Dr. Jonathan N. Stea @jonathanstea.bsky.social · 03/09/2026
I once asked Daniel Kahneman (Nobel Prize recipient) to be involved in a book I was co-editing. Though qualified, he so very kindly declined, citing his lack of expertise. When I contrast his humility with the daily death of expertise on social media, I die a little inside.
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The Transmitter @thetransmitter.bsky.social · 27/08/2026
A network of more than 1,800 protein-protein interactions reveals how autism-associated proteins converge on similar complexes and mechanisms. By @claudia-lopez.bsky.social www.thetransmitter.org/spectrum/aut...
thetransmitter.org
Autism-linked variants rewire protein networks
The myriad proteins tied to autism cluster together in previously unrecognized ways that can be disrupted by specific variants in the proteins.
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Prof Anthony Isles @profantisles.bsky.social · 28/08/2026
Nice work from my Cardiff colleagues
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Nature @nature.com · 21/08/2026
Nature research paper: Human brain organoids record the passage of time over multiple years go.nature.com/4xT4Ked
go.nature.com
Human brain organoids record the passage of time over multiple years - Nature
Human brain organoids were developed for over five years in culture to demonstrate that brain cells can continue to mature and record the passage of time, following human-specific endogenous programs, even outside the context of the organism.
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PaquetLab @paquetlab.bsky.social · 05/08/2026
🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de published in @natneuro.nature.com: We developed a highly reproducible 3D human brain tissue model (3BTM) that enables studying microglial phenotypes in health and disease! #OA PDF here: rdcu.be/fxLou Thread👇: 1/11
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Max Delbrück Center @mdc-berlin.bsky.social · 16/07/2026
Organoids models often consist of immature cells. Models that resemble adult tissue would be better for studying late-onset diseases like ALS. Our scientists show that electrical pulse stimulation helps organoid to mature. Details: www.mdc-berlin.de/news/news/el...
scientific image. Headline: "Electrical stimulation helps organoids mature"
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Jack Underwood @jfgunderwood.bsky.social · 30/06/2026
Pleased to share our new paper, out open-access in Psychological Medicine. In this work we looked at the relationship between childhood trauma, autism/ autistic traits and depression over a 28 year follow-up in the ALSPAC birth cohort.
cambridge.org
Childhood trauma as a mediator between autistic traits and depression: Evidence from the ALSPAC birth cohort | Psychological Medicine | Cambridge Core
Childhood trauma as a mediator between autistic traits and depression: Evidence from the ALSPAC birth cohort - Volume 56
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The Royal Society @royalsociety.org · 30/06/2026
In 'How to Change a Memory', Steve Ramirez draws on his own memories of friendship, family, loss and recovery to reveal how memory can be turned on and off like a switch, edited and even constructed from nothing. royalsociety.org/medals-and-p...
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Sean Carroll @seanmcarroll.bsky.social · 30/06/2026
Scientists, especially younger ones, are going to have to come to terms with the idea that “doing science” is no longer enough. We all have to fight for science: what it means, what are its values, and why it matters.
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Science Magazine @science.org · 25/04/2026
In a new study, researchers describe a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide. Learn more on #DNADay: scim.ag/3OEc2RV
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Sagiv Shifman @sagivshifman.bsky.social · 14/04/2026
Why do pathogenic variants in the same gene lead to different neurodevelopmental outcomes? Our Trends in Genetics review discusses how variant effects, genetic background, environment, and developmental noise may all contribute. www.cell.com/trends/genet... authors.elsevier.com/a/1mxFv_3rsx...
cell.com
Complex genotype–phenotype relationships in neurodevelopmental disorders
With the advent of sequencing technologies in recent years, hundreds of high-confidence risk genes have been implicated in neurodevelopmental disorders (NDDs). However, individuals carrying pathogenic...
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Athena Akrami @athenaakrami.bsky.social · 07/04/2026
Academic friends, It's beyond heartbreaking to watch what's unfolding in Iran & the region. A few of us drafted an open letter calling for protection of civilians & of educational, research, medical & cultural institutions. Please read & sign if you agree: sites.google.com/view/protect... #IranWar
sites.google.com
Protect Academic Life in Iran
We, the undersigned academics and researchers from around the world, express our profound concern over recent military strikes on Iran, the retaliatory responses, and the reported impact on civilian l...
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Ana Dorrego Rivas @adorrego.bsky.social · 11/02/2026
The International Day of Women and Girls in Science is definitely one to celebrate. We have come a long way, and the future is bright and hopeful. But to get there, we need to keep acknowledging the systemic biases that sadly still exist nowadays 👇🏻
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Sergiu P. Pasca @sergiuppasca.bsky.social · 29/01/2026
This week, we report in @nature.com our effort to identify molecular convergence and divergence in #autism spectrum disorder (ASD) using human stem cell models.
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Prof Anthony Isles @profantisles.bsky.social · 28/01/2026
Pleased to be able to offer a summer placement at the Centre for Neuropsychiatric Genetics and Genomics @cardiffuni.bsky.social through this scheme. Research Access Placements are open to undergraduates from underrepresented backgrounds @gensocuk.bsky.social
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The Transmitter @thetransmitter.bsky.social · 14/01/2026
Most iPSC lines come from European donors. Now, two teams in Africa are studying neurodevelopment and neurodegeneration using iPSCs and organoids from African donors. By Lauren Schenkman www.thetransmitter.org/cellular-neu...
thetransmitter.org
Bringing African ancestry into cellular neuroscience
Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.
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Ted Abel @tedabelneuro.bsky.social · 05/01/2026
Check out our new manuscript describing the circuit-specific impact of 16p11.2, a chromosomal region linked to neurodevelopmental disorders! @UIowaNeuro @IowaNeuroPharm @Hawk_IDDRC www.nature.com/articles/s41...
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allen institute @alleninstitute.org · 29/12/2025
Holiday travel ahead? Add a little science to your journey with our #LabNotes podcast! Recent episodes explore: ⚙️ Engineering life 🧠 Science of addiction (and possible paths to cures) 💻 Creating a digital brain 🛰️ Sending stem cells to space 🎧: alleninstitute.org/podcast-lab-notes
alleninstitute.org
Lab Notes | Podcast
A podcast by the Allen Institute revealing the human stories behind headline-grabbing science
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Science Friday @scifri.bsky.social · 28/12/2025
A wonderful reminder from physicist and author Sean M. Carroll. 📖
"We have to keep up the romance and the idealist notions of what it means to learn things and to be a better educated person... Take time to learn things. It's one of the best things you could do with your time." —Dr. Sean M. Carroll
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fatimasnc.bsky.social @fatimasnc.bsky.social · 19/12/2025
Your new batch of cortical organoids resulted in mixed regional identities closer to hindbrain. Why is patterning so hard?😩 ✨Our latest paper might help you✨ tinyurl.com/neorgpat #morphogen #neuralorganoids #patterning #scRNAseq @graycamplab.bsky.social @ethz.ch @nazbukina.bsky.social
A summary schematic showing morphogen gradients in the developing human embryo, an overview of two screenings performed in the study (one testing factors related to patterning conditions, another one testing factors related to patterning reproducibility) and icons representing the main readouts of the screenings: organoid cell type composition, measures of morphogen interactions, primary atlas comparison and regulon activity.
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Prof Anthony Isles @profantisles.bsky.social · 19/12/2025
If you want to learn more about #MURIDAE project and @mrcmousenetwork.bsky.social @mrcharwell.bsky.social to which this position is linked, please read this brief overview of our symposium at the @britishneuro.bsky.social Festival of Neuroscience #BNA2025 🧠🐭🧬 journals.sagepub.com/doi/10.1177/...
journals.sagepub.com
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
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allen institute @alleninstitute.org · 24/11/2025
🧠 Basal Ganglia data is now explorable, mappable, and programmatically accessible. Includes both single-cell and spatial transcriptomics. 🔗 brain-map.org/consortia/hm...
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BK. Titanji @boghuma.bsky.social · 20/11/2025
If there was any doubt at all that the CDC is fully destroyed, this page on autism and vaccines on its website confirms it. It's now just another vessel of dangerous health misinformation. I have no words. This is beyond sad.
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Dr. Dawn Bowdish @msmacrophage.bsky.social · 17/11/2025
Would you like to learn about how vaccines protect the aging brain from dementia? I'll be doing this free webinar on the topic with Anthony Levinson & @miramcmaster.bsky.social . Free, fun, and fact-based. I would love to see you there.
alumlc.org
ALC | Watch | McMaster University Alumni Webinars and Online Events
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Alex Hoischen @ahoischen.bsky.social · 17/11/2025
Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social. www.radboudumc.nl/en/news-item... (1/n)
radboudumc.nl
World first: Radboudumc pioneers new genetic test in clinical practice - New test is faster, more efficient, and provides more diagnoses for rare diseases
17 November 2025
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Bita Moghaddam @bita137.bsky.social · 07/11/2025
Raise a glass for Rosalind Franklin tonight and honor her memory and scientific contributions
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Harmit Singh Malik @harmitmalik.bsky.social · 07/11/2025
When people celebrate the individual genius of folks in science, they should also mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
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Johanna Joyce @johannajoyce.bsky.social · 05/11/2025
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬 An amazing set of resources for all scientists working on the brain! 🧠 Immersive feature: www.nature.com/immersive/d4... 🧠 Perspective: www.nature.com/articles/s41...
Cover of this week's Nature showing a brain rendering

Cover caption from the journal:
Brain development:
Our ability to process information into complex emotions, behaviours and decisions relies on the rich diversity of cell types that make up the human brain. Uncovering the molecular and cellular events that take place during brain development could reveal not only the mechanisms that give rise to this diversity but also shed light on how this process might go awry in neurodevelopmental disorders such as autism and schizophrenia. In this week’s issue, the BRAIN Initiative Cell Atlas Network (BICAN) builds on its previous work creating atlases of cell types in the adult mouse, non-human primate (NHP) and human brains to present cell-type atlases of the developing human, mouse and NHP brains. Across a suite of papers, nine of which are published in Nature, the researchers uncover the complex programs through which cell types emerge during brain development in humans and animals, revealing both the shared and unique features of the human brain. The latest work, along with future research directions, is summed up in a Perspective article by Tomasz Nowakowski and colleagues
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Alessandro Gozzi @gozziale.bsky.social · 04/11/2025
Great coverage by @thetransmissions.bsky.social of our latest preprint: adding new evidence (and a hint of controversy 🙂) to the E/I imbalance debate in autism 👇👇 www.thetransmitter.org/spectrum/ram...
thetransmitter.org
Ramping up cortical activity in early life sparks autism-like behaviors in mice
The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.
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Prof Anthony Isles @profantisles.bsky.social · 29/10/2025
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS 🐭🧬
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Timothy Caulfield @caulfieldtim.bsky.social · 30/10/2025
Covid in pregnancy tied to autism, developmental issues, study wapo.st/4hB1OvP Emphasized: "an observational study, the findings do not prove that covid causes the conditions..." Still "...the findings underscore the importance of covid-19 vaccination during pregnancy"
wapo.st
Covid in pregnancy tied to autism, developmental issues, study says
A study published in the journal Obstetrics and Gynecology analyzed more than 18,100 births in Massachusetts of children born to women who contracted the virus starting in the early months of the pand...
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UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · 31/10/2025
🧟This Halloween, explore how eerie experiments and 19th-century neuroscience shaped the darkest corners of gothic literature. Join @selinawray.bsky.social, @caswell.bsky.social & @drjlange.bsky.social for a spooktacular Brain Stories. 🎃 Listen: share.transistor.fm/s/51e18001 @uclqsion.bsky.social
media.tenor.com
a black and white photo of frankenstein laying on a bed with his eyes closed
ALT: a black and white photo of frankenstein laying on a bed with his eyes closed
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Varun Warrier @vw1234.bsky.social · 01/10/2025
This was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app. Article: www.nature.com/articles/s41...
nature.com
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
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King's College London @kingscollegelondon.bsky.social · 30/09/2025
Living in an unequal society, regardless of individual wealth, can lead to structural changes in the brains of children. #ScienceatKings #PopulationHealth
theguardian.com
Study links greater inequality to structural changes in children’s brains
Researchers say findings show inequality creates toxic environment and reducing it is ‘a public health imperative’
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Eric Topol @erictopol.bsky.social · 25/09/2025
A new @nature.com feature on autism with real data and facts Published today, written before the Tylenol debacle. ' Kennedy and the HHS are “going to falsely declare the cause for autism — and that that gets in the way of a great deal of progress”.' www.nature.com/articles/d41...
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allen institute @alleninstitute.org · 17/09/2025
Copy our protocols! 📝 Find many of our lab protocols and techniques on @protocolsio.bsky.social at www.protocols.io/search?q=%22... 🎥 Go deeper with recorded video tutorials of some of our most requested methods: alleninstitute.org/education/sc... #OpenScienceWeek
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Jatin Nagpal @jatinnagpal.bsky.social · 17/09/2025
Great to see our review on microbiome, exposome and cognitive development out in @annualreviews.bsky.social. @apcmicrobiomeirel.bsky.social @uccresearch.bsky.social #MicrobiomeSky #Gut-Brain
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Ilaria Morella @ilariamorella.bsky.social · 13/09/2025
Incredible resource and a big step forward in modelling neurodevelopmental disorders 👇🏻 #organoids #neurodevelopment
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Alessandro Gozzi @gozziale.bsky.social · 10/09/2025
🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience ➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism? Check out what we found! 🧵1/n
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Saba Altaf @sabaaltaf.bsky.social · 06/09/2025
Our lncRNA-in-brain review is out in @natrevneuro.nature.com ✨ The emerging roles of long noncoding RNAs in the brain We discuss 🧬 lncRNA roles in brain development, synaptic function, learning, & behavior 💡 Therapeutic potential and future directions. @unswrna.bsky.social @unswbabs.bsky.social
innatrevneuro.nature.com
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OneNeuro Initiative @oneneurojhu.org · 05/09/2025
OneNeuro's August #FotoFriday #FluorescenceFriday contest winner is "Cellular Subtype Composition of an Amphetamine-activated Ensemble in mPFC," by Suhaas Adiraju from @martinowk.bsky.social at the @lieberinstitute.bsky.social View the complete gallery here: www.oneneurojhu.org/art/
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Ilaria Morella @ilariamorella.bsky.social · 05/09/2025
Honoured to have shared our recent findings on 16p11.2 CNV-associated syndromes at the Neurofront meeting at University of Bari. Inspiring talks covering precision medicine, biomarkers discovery, stem cells, advanced imaging and glial cells. Looking forward to the next meeting!
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Prof Anthony Isles @profantisles.bsky.social · 01/09/2025
I am a co-supervisor on one of these #PhD projects, led by @asamioguroando.bsky.social Find the details here: gw4biomed.ac.uk/neuronal-clu...
gw4biomed.ac.uk
Neuronal Clues to Astrocytes: Uncovering Hidden Mechanisms in the Developing Brain - GW4 BioMed MRC DTP
Project Code MRCNMH26Ex Oguro-Ando Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary How do neuronal signals drive astrocyte-mediated changes in brain...
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Stacey Ogden 🦔 @labogden.bsky.social · 25/08/2025
Are you interested in understanding how cells communicate during development? We are now accepting applications for a Senior Scientist in my group at St. Jude Children's Research Hospital! Please ✅ out the link below. Reposts appreciated! 🧪 👩‍🔬 🔬 stjude.wd1.myworkdayjobs.com/stjude/job/M...
stjude.wd1.myworkdayjobs.com
Senior Scientist- Ogden Lab
The Ogden lab's current efforts are aimed at understanding how cells exchange signals through specialized filopodia to drive tissue morphogenesis in the developing nervous and cardiopulmonary systems....
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Indigo V. L. Rose @ivlrose.bsky.social · 23/08/2025
Ever wanted to do a CRISPR screen directly in the mammalian brain? While perturbing thousands of genes in parallel? All while targeting specific cell types? Check out our latest paper describing CrAAVe-seq, a powerful new functional genomics tool for massively parallel neuroscience research
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UK Dementia Research Institute @ukdri.ac.uk · 22/08/2025
Could a vaccine help prevent dementia? Data suggests the shingles vaccine is linked to a lower risk of developing dementia, adding to evidence that viral infections could influence brain health. 🎙️@tspiresjones.bsky.social breaks down the findings on BBC Radio 4's Inside Health ⬇️
buff.ly
BBC Radio 4 - Inside Health, Potential Break Through in Dementia Treatment
Shingles vaccine to reduce dementia risk? Antibiotic resistant gonorrhoea & tech trousers
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Science Magazine @science.org · 22/08/2025
A new #ScienceReview looks at a different approach to drug discovery that may enable drugging of unconventional targets through stabilization of macromolecular complexes with molecules known as “LOCKTACs.” Learn more: scim.ag/4lC2aCM
LOCKTACs comprise a subset of proximity drugs that stabilize naturally existing complexes. (A) Categories of proximity-based drugs. (B) Mechanism of PROTAC drugs. (C) LOCKTAC acting within a protein-protein interface. (D) LOCKTAC acting adjacent to a protein-protein interface. (E) Heterobifunctional LOCKTAC that does not bind at protein-protein interface. (F) Allosteric drugs induce conformational changes at a distance and are not LOCKTACs.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 21/08/2025
Important initiative 👇
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