Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 24/09/2026www.isd-research.de/news/dynamic...isd-research.de 000
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 18/08/2026Congratulations! ISD researcher Jule Filler received the Young Investigator Award at the European Stroke Organisation Conference (ESOC) 2026 in Maastricht for her work "Early plasma NfL predicts cognitive outcomes 5 years after stroke" 👏👏👏 www.isd-research.de/isd-research... 000
Reposted by Institute for Stroke and Dementia Research (ISD)Healthcare in Europe (DE) @health-europe-de.bsky.social · 12/08/2026🧠 Ein Team um @paquetlab.bsky.social vom @isd-research.bsky.social des @lmu-klinikum.bsky.social hat ein neuartiges 3D‑Gewebemodell entwickelt, das die komplexen Zusammenhänge im Gehirngewebe bei #Alzheimer real abbildet. Das könnte die Erforschung der neurodegenerativen Erkrankung voranbringen.healthcare-in-europe.comAlzheimer-Forschung: Modell bildet Hirngewebe in 3D abWie lässt sich die Erforschung der Alzheimer-Demenz schneller, effektiver und besser machen? Nach Jahrzehnten intensiver Forschung weltweit und trotz jüngster therapeutischer Fortschritte ist es bisla... 032
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 17/08/2026Rolf Becker Prize for ISD Researcher Dominik Paquet and Angelika Dannert for their publication on a three-dimensional model of the human blood brain barrier developed entirely from induced pluripotent stem cells .. Congrats! @paquetlab.bsky.social 000
Reposted by Institute for Stroke and Dementia Research (ISD)LMU Klinikum München @lmu-klinikum.bsky.social · 11/08/2026🏆 LMU Medical Scientist of the Year 2026: Dr. Naomi Vlegels wurde für ihre Forschung zu tau-Proteinen und Hirnschäden nach Schlaganfall ausgezeichnet. Im Video erzählt sie mehr über ihre Arbeit und ihre tägliche Inspiration. lmu-klinikum.de/scrivito/new...lmu-klinikum.deLMU Medical Scientist of the Year 2026: Dr. Naomi VlegelsAuf dem Jahresempfang der Medizinischen Fakultät der LMU wurde Dr. Naomi Vlegels vom Institut für Schlaganfall- und Demenzforschung für ihre Arbeit "Brain-derived tau for monitoring brain injury in ac... 012
Reposted by Institute for Stroke and Dementia Research (ISD)PaquetLab @paquetlab.bsky.social · 05/08/2026🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de published in @natneuro.nature.com: We developed a highly reproducible 3D human brain tissue model (3BTM) that enables studying microglial phenotypes in health and disease! #OA PDF here: rdcu.be/fxLou Thread👇: 1/11 32212
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 16/07/2026ISD researchers found that the brain’s modular network organization influences how amyloid-driven tau pathology spreads. Published in Alzheimers&Dementia: alz-journals.onlinelibrary.wiley.com/doi/10.1002/... 001
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 25/06/2026ISD researchers investigated how plasma biomarkers (phosphorylated tau 217 [ptau217], glial fibrillary acidic protein [GFAP], neurofilament light chain [NfL]) relate to imaging markers of SVD and AD, and cognition in memory clinic patients. -> doi.org/10.1002/alz.... 000
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 26/05/2026www.nature.com/articles/s41...nature.comA deep-learning framework reveals whole-body perturbations at cell level - NatureAn analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia. 000
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 06/05/2026The SFB 1744 / CRC 1744 website is now published www.sfb1744.de 🎊 It not only represents work, events, publications of the CCN in NVD network but furthermore offers a platform for the Graduate Program IRTG-BrainVasc including open PhD positions! www.sfb1744.de/sfb1744 www.sfb1744.de/open-positio... 011
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 24/04/2026Advanced Clinician Scientist Program for Comprehensive Neuroscience (PROMISE) www.med.lmu.de/de/wissensch... 013
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 23/04/2026CRC1744 Launch – Kick-off Event With the official launch of CRC1744 we welcomed principal investigators and early career researchers as well as distinguished guest speakers to a one-day kick-off meeting. www.isd-research.de/news/crc1744... 030
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 21/04/2026A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology | Science Translational Medicine www.science.org/eprint/5H5YD...science.orgA human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathologyA human iPSC–derived tauopathy model endogenously recapitulates late-stage pathology and enables translational applications. 040
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 19/03/2026Biomarkers for advancing diagnosis and prognosis in stroke - www.sciencedirect.com/science/arti... 000
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 17/03/2026ISD Investigators have secured major funds from Germany’s Federal Ministry of Research, Technology and Space, to strengthen clinician-led, translational neuroscience research. PROMISE will support 12 competitively selected Advanced Clinician Scientists >> www.isd-research.de/scrivito/adv... 001
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 19/02/2026Image of the Week: Congrats to the team of González-Gallego J et al., Nat Neurosci. 2026 for this lovely award in Nature Briefing 🏆 🖼️ @judit-gonzalez.bsky.social @paquetlab.bsky.social (->Fig 2b www.nature.com/articles/s41...) 022
Reposted by Institute for Stroke and Dementia Research (ISD)Alzheimer Forschung Initiative @afi-ev.bsky.social · 17/02/2026Frühe und verlässliche Diagnostik ist ein Schlüssel in der Alzheimer-Forschung. Dr. Anna Dewenter forscht am @isd-research.bsky.social der @lmu.de genau daran. In ihrem AFI-Projekt untersucht sie mithilfe moderner MRT-Bildgebung feine Veränderungen der weißen Hirnsubstanz.youtube.comVollautomatisiertes Verfahren zur Diagnostik einer Alzheimer-assoziierten GefäßerkrankungYouTube video by Alzheimer Forschung Initiative 001
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 15/01/2026Brain-derived tau for monitoring brain injury in acute ischemic stroke - Great work by Steffen Tiedt, his team of ISD researchers and international partners now published in Science Translational Medicine: www.science.org/doi/10.1126/... 🎊🙌 #BD-tau #ischemicscience.orgBrain-derived tau for monitoring brain injury in acute ischemic strokeBrain-derived tau in plasma reflects the extent of brain injury in acute ischemic stroke, predicts functional outcomes, and detects treatment effects. 020
Reposted by Institute for Stroke and Dementia Research (ISD)PaquetLab @paquetlab.bsky.social · 15/12/2025New paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10 1279
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 10/12/2025Congratulations! 🏆 The European Research Council has awarded the prestigious ERC Consolidator Grant to support TRAINED, a project led by Arthur Liesz (ISD) that investigates how maladaptive trained immunity drives systemic inflammation and multimorbidity after stroke and myocardial infarction. 120
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 25/11/2025German Research Foundation (DFG) has approved funding of a new CRC on “Compartmentalized Cellular Networks in Neurovascular Diseases”. Thanks to everyone involved!🙏 www.lmu.de/en/newsroom/... 020
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 25/11/2025Synaptic density and tau pathology in Alzheimer’s disease: a dual role in susceptibility and degeneration url: academic.oup.com/brain/articl...academic.oup.comSynaptic density and tau pathology in Alzheimer’s disease: a dual role in susceptibility and degenerationLuan et al. used dual PET imaging to examine the relationship between synaptic density and tau pathology in Alzheimer’s disease. They show that synapse-ric 010
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 13/11/2025Happy to find Martin Dichgans on the list of Highly Cited Researchers™ once more 🎉 clarivate.com/highly-cited... 020
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 20/10/2025Key risk factors for post-stroke dementia uncovered: results from DEMDAS study identify metabolic syndrome + reduced HDL cholesterol as novel, modifiable risk factors for post-stroke dementia... www.thelancet.com/journals/lan... 010
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 15/09/2025Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease url: academic.oup.com/brain/articl... #tao @nfranzme.bsky.socialacademic.oup.comCortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s diseaseIn Alzheimer’s disease, tau pathology not only contributes to cortical atrophy but also leads to the degeneration of white matter tracts that connect diffe 052
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 09/09/2025Marios Georgakis and team showed IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk www.nature.com/articles/s44... 010
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 09/09/2025Mikael Simons receives $500,000 for a project to investigate disease mechanisms involving tau proteins. The funding is part of the international program „Tauopathy Challenge Workshop 2025“, supporting research projects aimed at understanding and treating tau-associated diseases such as AD. 🎉 010
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 10/07/2025Annual ISD Research Retreat 🎆 Great talks, project presentations, poster session, games, guest talks and an amazing LLM workshop by Rainer Malik 🙏 031
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 02/06/2025Arthur Liesz received the prestigious ESO Scientific Excellence Award for his contributions to the understanding of stroke and neurovascular disease. The award was delivered in the Presidential Session at the European Stroke Organisation Conference (ESOC 2025) in Helsinki. @arthurliesz.bsky.social 👏 141
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 27/05/2025The Munich Cluster for Systems Neurology (SyNergy) has been awarded a third funding period (2026-2032) by the DFG. 🎆 👏 @synergy-munich.bsky.social 060
Reposted by Institute for Stroke and Dementia Research (ISD)Alzheimer Forschung Initiative @afi-ev.bsky.social · 16/04/2025Die Europäische Kommission hat den Wirkstoff Lecanemab (Handelsname: Leqembi) zur Behandlung der Alzheimer-Krankheit im frühen Stadium zuzulassen. Damit wird es erstmals in Deutschland eine Alzheimer-Behandlung geben, die ursächlich an einer der möglichen Krankheitsursachen angreift.alzheimer-forschung.deZulassung LeqembiEuropäische Kommission lässt Wirkstoff Lecanemab (Handelsname: Leqembi) zur Behandlung der Alzheimer-Krankheit im frühen Stadium zu. 031
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 14/04/2025Interested in cellular mechanisms of cognitive decline after stroke? Check out this work in Nature communications: Anna-Sophia Wahl lab track the fate of individual neurons involved in spatial memory before + after multiple, distributed microstrokes using chronic 2photon imaging in-vivo. 👍rdcu.beBrain-wide microstrokes affect the stability of memory circuits in the hippocampusNature Communications - To reveal cellular mechanisms of cognitive decline after stroke the authors established an experimental paradigm in mice monitoring individual nerve cells involved in... 0102
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 14/04/2025For his research project “Reprogrammed microglial cells as a therapeutic approach against Alzheimer's Disease” Dominik Paquet receives funding from the Alzheimer Forschung Initiative 🙌 @afi-ev.bsky.social www.alzheimer-forschung.de/forschung/fo... 121
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 18/03/2025Alpha-synuclein co-pathology promotes tau accumulation in Alzheimer’s disease - findings by ISD investigators published in Molecular Neurodegeneration 👏 rdcu.be/ed0Su @nfranzme.bsky.social @springernature.com 171
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 13/03/2025An atypical chemokine that links atherosclerosis and metabolic disease - A new study led by ISD staff identifies D-dopachrome tautomerase (D-DT/MIF-2) as an atypical chemokine that promotes both atherosclerosis and hepatic lipid accumulation. (...) read: 👉 www.isd-research.de/scrivito/isd... 👏 010
Reposted by Institute for Stroke and Dementia Research (ISD)PaquetLab @paquetlab.bsky.social · 12/03/2025Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply 0159
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 06/03/2025Finally printed: ISD Annual Report 2023/2024: Nice overview about the last years of research life and events at the institute. Thanks to everyone who contributed.🫶 www.isd-research.de/about-us/med... 020
Reposted by Institute for Stroke and Dementia Research (ISD)Alzheimer Forschung Initiative @afi-ev.bsky.social · 06/03/2025Prof. Dr. Paquet (@paquetlab.bsky.social) von der LMU München und sein Team züchten Mikrogliazellen mit neuen Rezeptoren, die schädliche Eiweiße wie Amyloid-beta besser erkennen und beseitigen sollen. Mit dieser Strategie könnten die neuen Alzheimer-Therapien ergänzt werden. Mehr Infos im Video!youtube.comDemenz-Forscher Prof. Dr. Dominik PaquetYouTube video by Alzheimer Forschung Initiative 012
Reposted by Institute for Stroke and Dementia Research (ISD)SyNergy - Munich Cluster for Systems Neurology @synergy-munich.bsky.social · 18/02/2025👋 Meet our PhD and Postdoc Representatives 💭 The voice of our PhD students and Postdocs. A point of contact for feedback, questions, criticism, and improvements. And they organize extracurricular activities! Meet @angelikadannert.bsky.social, Clara, Lis and Nathalie. 🔗 Read more: lnkd.in/dKtzshqr 177
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 29/01/2025www.cell.com/immunity/ful... - 👉ISD investigators now defined a mechanism whereby HDAC9 regulates activation of the NLRP3 inflammasome and developed a targeted anti-inflammatory approach for treating atherosclerosis. #HDAC9 #cell #immunity 055
Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 27/01/2025A study led by ISD researchers suggests a key mechanistic link between Aβ and tau accumulation in Alzheimer’s disease, showing that Aβ induces neuronal hyperconnectivity, thereby promoting the spread of tau pathology across interconnected brain regions. 👍 www.science.org/doi/10.1126/... 131