iiinova — where your digital self keeps evolving

Sergiu P. Pasca @sergiuppasca.bsky.social · 28/09/2026

The 5th edition of the CSHL meeting on neural #organoids, #assembloids & human development is approaching! Since the first meeting in 2017, this has become a special forum for the field. This edition promises outstanding speakers, strong trainee engagement & the perfect setting to hear the latest

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Sergiu P. Pasca @sergiuppasca.bsky.social · 25/09/2026

Here’s a short summary of our recent #xenocortication article in @nature.com, including the rationale, approach, key findings, application to disease modeling & current limitations. A tremendous effort led by Konstantin Kaganovsky, Kevin Kelley, Tilo Gschwind, and Paul Harary. Article below 👇

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Sergiu P. Pasca @sergiuppasca.bsky.social · 24/09/2026

Superb work from Helen Bateup’s lab in @nature.com this week, led by the remarkable Tommy Li— a former PhD student at Stanford & lan alumnus. Using regionalized cortical #organoids, they discover glia as major players in tuberous sclerosis.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026

Today in Nature @nature.com, we report a new approach to studying human brain development and modeling disease in vivo. Open article link below 👇

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Kevin Kelley @kevinkelley.bsky.social · 16/09/2026

9/ Thank you to all co-authors. Really enjoyed working closely with Konstantin, Tilo, Paul Harary. Very grateful to @sergiuppasca.bsky.social for his vision, support, and mentorship. Here is the paper: www.nature.com/articles/s41...

nature.com

Developmental xenocortication using human-derived organoids in mice - Nature

Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026

Thank you @nitafarahany.bsky.social Very grateful for the discussions and guidance!

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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026

Thank you, Kevin! There are many questions about development that we can now begin to address, including what you’ve been proposing for a long time about stochasticity in neural assembly. @wiringthebrain.bsky.social

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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/09/2026

Thank you @anilseth.bsky.social Really appreciate this and your thoughtful perspective on the work.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 10/09/2026

This year, we captured our Stanford Brain Organogenesis Center hand-on workshop on human stem cell models course in action. Every year here on campus , we share methods developed in our lab for generating and applying #organoids and #assembloids. A glimpse of it here: youtu.be/J-TJfdO11AQ?...

youtu.be

Stanford Brain Organogenesis Workshop (2026)

YouTube video by Sergiu Pasca, MD

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Sergiu P. Pasca @sergiuppasca.bsky.social · 28/08/2026

Thank you to everyone who shared our Executive Director search last week! As our effort takes off, 2 more positions are now open: a Clinical Trials Regulatory Manager and a Clinical Coordinator Please share with anyone who might be a fit!

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Sergiu P. Pasca @sergiuppasca.bsky.social · 20/08/2026

We are building a new translational effort at focused on advancing therapies for severe neuropsychiatric disorders. We are recruiting an Executive Director to help shape this initiative across @stanfordmedicine.bsky.social and Lucile Packard Children’s Hospital.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 08/07/2026

Our article, led by the remarkable Xiangling Meng, on establishing CRISPR screens in neural #assembloids and #organoids is on the cover of Nature Protocols today

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Sergiu P. Pasca @sergiuppasca.bsky.social · 29/06/2026

The 5th edition of the @cshlmeetings conference on Development and Modeling of the Human Brain with #assembloids and #organoids will take place in December. We will have a spectacular group of speakers and a series of selected talks from trainees. Deadline in September. More below 👇

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Sergiu P. Pasca @sergiuppasca.bsky.social · 11/06/2026

Check out this Venice Neuroscience course on #assembloids, which I am co-organizing with @jimena-andersen.bsky.social and @fikri-birey.bsky.social, who developed the initial assembloid system a decade ago. It promises to be a fun week, with a spectacular lineup of speakers and in-depth discussions.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 14/05/2026

This week we welcome at Stanford a remarkable cohort from all the over the world for our hands-on course on human brain #assembloids & #organoids! Amazing energy as they learn methods developed in the lab over the years, and as we discuss and troubleshoot the projects they are building home.

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Sarah DeWeerdt @sarahdeweerdt.bsky.social · 01/05/2026

Loved working on this story because it illustrates the interdependence of science: an innovation from one lab unexpectedly clears a roadblock that had stymied another, which then leads to advance that opens up a whole new space for others to explore. Thanks @sergiuppasca.bsky.social for sharing w me

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Sergiu P. Pasca @sergiuppasca.bsky.social · 24/04/2026

Deeply honored to receive the Sir Wilfrid Le Gros Clark Prize, and very grateful for this recognition as I look forward to delivering the lecture at Oxford @ox.ac.uk next week.

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Simon Fisher @profsimonfisher.bsky.social · 08/04/2026

“Over the next decade these stem-cell-based models will increasingly help reveal the biology of complex brain conditions & demystify diseases that have long remained inaccessible” says organoid guru @sergiuppasca.bsky.social in this Nature news piece on an elegant & beautiful area of modern science🧪

nature.com

Mini models of the human brain are revealing how this complex organ takes shape

Lab-grown organoids are turbo-charging the study of human brain development and disease.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 02/04/2026

Several staff scientist positions available in our lab at Stanford University! More details and application at the link below

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Sergiu P. Pasca @sergiuppasca.bsky.social · 11/03/2026

This week we are introducing neuromodulatory assembloids. Over the past few years, many circuits and cell-cell interactions have been modeled in assembloids, but these systems have not systematically incorporated neuromodulation.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 05/03/2026

So fun to meet lab alumni at conferences and watch how their own labs are thriving! Really happy to see Jimena Andersen, now faculty at Emory University. When she was at Stanford, Jimena built 3-part #assembloids to study the corticospinal pathway

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Sergiu P. Pasca @sergiuppasca.bsky.social · 18/02/2026

It is a privilege to join the Board of this organization committed to accelerating discoveries that accelerate our understanding and treatment of human disease by supporting fundamental research.

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Stem Cell Podcast @stemcellpodcast.com · 06/02/2026

The latest @nature.com paper from Drs. @sergiuppasca.bsky.social and Daniel Geschwind's labs uses cortical #organoids to model #AutismSpectrumDisorder, and identifies how genetic risk can impact neurodevelopment. 🖇️ go.nature.com/4qZUzkS 🗨️ bit.ly/4thHuVG

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Sejin Yoon @sejinyoon.bsky.social · 30/01/2026

I am happy to share our paper uncovering developmental convergence and divergence in autism spectrum disorder (ASD) using human stem cell models. This work was made possible through a wonderful collaboration with Sergiu Pasca’ lab @sergiuppasca.bsky.social and Daniel Geschwind’s lab.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 29/01/2026

This week, we report in @nature.com our effort to identify molecular convergence and divergence in #autism spectrum disorder (ASD) using human stem cell models.

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Waggoner Lab @labwaggoner.bsky.social · 29/01/2026

Risk associated with genetically defined forms of ASD can propagate by means of transcriptional regulation to affect convergently dysregulated pathways @nature.com @sergiuppasca.bsky.social @stanforduniversity.bsky.social @dgsomucla.bsky.social www.nature.com/articles/s41...

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Sergiu P. Pasca @sergiuppasca.bsky.social · 09/01/2026

A recent @npr.org piece by highlights the recent Asilomar meeting we organized on ethical considerations surrounding human stem cell models (#organoids & #assembloids and their transplantation), focusing on emergent questions and the potential to uncover new biology and therapeutics. Audio below 👇

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Sergiu P. Pasca @sergiuppasca.bsky.social · 23/12/2025

In our most recent publication in Nature Protocols, we outline detailed methods for performing CRISPR screens in neural #organoids and #assembloids. The integration of these approaches is becoming increasingly powerful for uncovering human biology and gaining mechanistic insights into disease.

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Stanford Brain Organogenesis Center @brainorganogenesis.bsky.social · 12/12/2025

Applications closing at 6pm PT today!

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Sergiu P. Pasca @sergiuppasca.bsky.social · 12/12/2025

Applications are pouring in for our international course on neural #assembloids taking place next spring on our beautiful Stanford campus This is the LAST day to apply! No deadline extensions. Please share 👇

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Sergiu P. Pasca @sergiuppasca.bsky.social · 10/12/2025

Remarkable energy at the inaugural @cshlnews.bsky.social conference on Assembloids and complex cell–cell interactions across tissues and systems A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging

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Emma Rawlins @labrawlins.bsky.social · 10/12/2025

Great meeting!!! Amazing talks and posters today also.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 09/12/2025

The inaugural conference on #assembloids and complex cell-cell interactions starting tonight at @cshlnews.bsky.social ! Amazing energy and inspiring opening keynote by Ruslan Medzhitov.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 06/12/2025

In a recent with Jan Carette’s lab, we introduce an #assembloid model for studying neuro-infection with enteroviruses including poliovirus. The videos below capture the loss of human muscle contraction, which is under the control of spinal cord neurons, after a week of infection.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 02/12/2025

Deadline approaching for participating in the international Stanford Course on Neural Assembloids in spring 2026! This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.

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Liset M. de la Prida @lmprida.bsky.social · 24/11/2025

We are moving neuroscience forward with the support of our outstanding SAB. @marinlab.bsky.social @mbartos.bsky.social @sergiuppasca.bsky.social Luthi, Heneka, Sanchez-Vives & Moro

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Sergiu P. Pasca @sergiuppasca.bsky.social · 02/12/2025

Looking forward to joining this group!

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Hank Greely @hankgreely.bsky.social · 20/11/2025

Article in @science.org on the Asilomar neural organoids meeting Sergiu Pasca & I co-organized last week. www.science.org/content/arti... Good summary...& we are still thinking about what comes next.

science.org

Lab-grown models of human brains are advancing rapidly. Can ethics keep pace?

Whether neural organoids feel pain or should be placed in animals are among the questions swirling around biology’s hot new technology

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Sergiu P. Pasca @sergiuppasca.bsky.social · 20/11/2025

This week we introduced an #assembloid-based platform to begin studying how #enteroviruses affect human neuromuscular systems. This is a collaboration with Jan Carette here at Stanford. Work led by Christine Peters, Jimena Andersen and Min-Yin Li.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 19/11/2025

Some ideas and discussions from our recent Asilomar meeting on the ethics and societal implications of neural organoid and assembloid research www.the-scientist.com/as-neural-or...

the-scientist.com

As Neural Organoid Research Accelerates, Scientists Discuss Ethics

Neuroscience experts convened in Asilomar to talk through guidelines around ethical research on human neural organoids.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 14/11/2025

An amazing group of scientists, philosophers, legal scholars, ethicists, policy makers, patient advocates, funders and trainees convened at Asilomar for one of the most stimulating meetings I have had the privilege to organize, focused on the ethics of research with neural #organoids & #assembloids

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stanfordbrain.bsky.social @stanfordbrain.bsky.social · 12/11/2025

Scientists and ethicists, including Wu Tsai Neuro affiliates @sergiuppasca.bsky.social and Hank Greely, call for an international process to guide the field of human neural organoids. Read the full @statnews.com story: www.statnews.com/2025/11/06/n...

Confocal light micrograph of a synaptic conjugation between three dimensional (3D) human embryonic stem cell (hESC)-derived brain organoids grown on an organ-on-chip (OOC) system. An OOC is a multi-channel 3D microfluidic cell culture. Organoids are miniature, simplified versions of organs grown in the laboratory. These organoids are being grown to study neural tube formation and neuronal development.

Image credit: Arthur Chien, Science Photo Library.

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Sergiu P. Pasca @sergiuppasca.bsky.social · 13/11/2025

Last day of discussions at this thought-provoking conference at Asilomar on the ethics and societal implications of neural organoids and assembloids, which I co-organized with @hankgreely.bsky.social

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Sergiu P. Pasca @sergiuppasca.bsky.social · 07/11/2025

This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.

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Dana Foundation @danafoundation.bsky.social · 27/10/2025

(1/2) Considering a career in neuroscience? In this bonus clip from NeuroSociety Stories, @sergiuppasca.bsky.social, a neuroscientist pioneering technology to recreate human brain tissue and neural circuits in the lab, shares why this is a pivotal moment for neuroscience. #neurosociety #neuroscience

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Sergiu P. Pasca @sergiuppasca.bsky.social · 23/10/2025

Applications are now open for the Stanford course on neural #assembloids! Deadline: December 12

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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/10/2025

By popular demand — the next edition of our hands-on @Stanford @BrOrganogenesis course is coming in 2026! This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease. 🧠 Deadline: mid-December

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