Wie lässt sich die Erforschung der Alzheimer-Demenz schneller, effektiver und besser machen? Nach Jahrzehnten intensiver Forschung weltweit und trotz jüngster therapeutischer Fortschritte ist es bisla...

Whole-brain tissue clearing and spatial transcriptomics were applied to map postnatal vascular development in the mouse brain, identifying three coordinated phases that link vascular growth to neurona...

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CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

Panagiotakopoulou et al. developed a co-culture system combining human cerebral organoids and mouse brain slices. The model supports long-term study of human microglia, enhances cortical marker expres...

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Microglia, the primary myeloid cells of the brain, are crucial for maintaining brain homeostasis and are implicated in various neuropathological processes. Microglial identity and function are determi...

Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...