Genetic association tests prioritize candidate genes based on different criteria.

Our one-year Master’s programme in Brain Health and Disease: Clinical Neurosciences offers an exceptional opportunity for students to engage with the forefront of clinical neuroscience through a dynam...

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Expression quantitative trait locus (eQTL) studies in human cohorts typically detect at least one regulatory signal per gene, and have been proposed as a way to explain mechanisms of genetic liability...

We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.

Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...

Females receive an attention deficit hyperactivity disorder (ADHD) diagnosis at an older age than males. We examined the antecedents and outcomes of later (age 12+) diagnosis in females using data fro...

Genetic factors influence vulnerability to common mental health conditions, but their role in early-life mental health remains understudied. We analysed genotype array and exome sequence data from two...

An independent taskforce set up to tackle challenges in attention deficit hyperactivity disorder (ADHD) care has published its interim report and recommendations today (Friday 20 June 2025). The repor...

Population structure is a well-known confounder in statistical genetics, particularly in genome-wide association studies (GWAS), where it can lead to inflated test statistics and spurious associations...

Nature Reviews Genetics - Genomic advances have enhanced our understanding of schizophrenia, bipolar disorder and major depressive disorder, revealing genetic architectures and risk mechanisms...

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...

Comparative genomic studies between contemporary and extinct hominins revealed key evolutionary modifications, but their number has hampered a system level investigation of their combined roles in sca...

This prognostic study evaluates the predictive performance of combining genetic variants and developmental milestones to predict intellectual disability in autistic children.

Recently, de novo variants in an 18 nucleotide region in the centre of RNU4-2 were shown to cause ReNU syndrome, a syndromic neurodevelopmental disorder (NDD) that is predicted to affect tens of thous...

An academic position as a Clinical Research Fellow in Psychiatry (2 Posts available) is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities...

Nature Genetics - Rare variant association analysis of plasma proteins using whole-genome sequencing data in 54,306 individuals in the UK Biobank demonstrates that combining both single-variant and...

Molecular Psychiatry - Polygenic scores for autism are associated with reduced neurite density in adults and children from the general population