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Jatin Nagpal

@jatinnagpal.bsky.social
1.8K followers 1K following 65 posts

💭 Neuroscience. Microbiome. Optogenetics. 📍APC Microbiome Ireland. University College Cork. 👤 Lecturer. Co-chair, UCC Race Equality Network. Director, ALBA Network. SciComm Coord., EU COST AFFECT-EVO. 📜 research.ucc.ie/profiles/jatin.nagp…

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Reposted by Jatin Nagpal
AFFECT-EVO @affect-evo.bsky.social · 27/09/2026
Have you already seen our AFFECT-EVO video? 🎥 Here's a teaser! Our COST Action unites researchers in biology, psychology, philosophy, social sciences, animal welfare and tech to understand affective states across species. Full video and how to join 👉 affect-evo.eu #AnimalWelfare #AnimalEmotions
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Reposted by Jatin Nagpal
APC Microbiome Ireland @apcmicrobiomeirel.bsky.social · 21/08/2026
We are recruiting a Postdoctoral Researcher at APC Microbiome Ireland and UCC to study links between the microbiota, neurodevelopment, stress and social behaviour with @jatinnagpal.bsky.social. 15 months | €47,273 to €53,925 | Apply by noon, 4 Sep: buff.ly/qnQNKyW #Postdoc #Microbiome #ResearchJobs
Hiring: Postdoctoral researcher to study early-life microbiome's effect on stress–social neural circuits in zebrafish; 15‑month role at UCC Cork; candidates with neuroscience, pharmacology, physiology, biomedical science or microbiology background; apply by 4 Sept 2026; supervisor pictured.
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Adrian Liston @labliston.bsky.social · 07/05/2026
I'm officially an expert in failing! I was asked to give the opening keynote today for a @cruk-ci.bsky.social conference, speaking on the topic "Failing in Science" youtu.be/BdrTzYcT7MY?...
youtu.be
Failing in science
YouTube video by Adrian Liston
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Jatin Nagpal @jatinnagpal.bsky.social · 30/11/2025
www.science.org/doi/10.1126/...
science.org
Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease
Intermittent fasting enhances cognition in Alzheimer’s disease via gut microbial indole-3-propionic acid activating neuronal PXR.
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Reposted by Jatin Nagpal
Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 22/10/2025
Gut bacterial metabolism of steroid hormones Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including anti-inflammatory prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability www.cell.com/cell-host-mi...
cell.com
Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway
Jacoby et al. identify a gut bacterial pathway that reduces natural and synthetic steroid hormones, including the anti-inflammatory drug prednisolone. This microbial activity is enriched in Crohn’s di...
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Reposted by Jatin Nagpal
ALBA Network @network-alba.bsky.social · 27/10/2025
🚀 #ALBADiversityWeek 2025 starts today! We celebrate diversity & intersectionality by highlighting key activities and sharing valuable resources. 👀 Stay tuned all week as we revisit achievements and launch new initiatives. Share our posts to join the #GlobalDiversityAwarenessMonth celebration. 🧵
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Carlos Ribeiro @ribeirocarlitos.bsky.social · 20/10/2025
New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...
cell.com
From cognition in the body to the body in cognition
Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform the study of ‘higher’ cognitive functions such as learning and memory across model systems.
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Jatin Nagpal @jatinnagpal.bsky.social · 16/10/2025
Had a great time discussing ‘What brain is the best to study disorders of behaviour’. Thanks to my fellow panelists and the audience for an enagaging session at European College of Neuropsychopharmacology (ECNP) 2025 meeting in Amsterdam. #ECNP2025
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Jatin Nagpal @jatinnagpal.bsky.social · 15/10/2025
Reaffirming the value of model organisms in training scientific minds | @natcellbio.nature.com www.nature.com/articles/s41...
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Reposted by Jatin Nagpal
John F. Cryan @jfcryan.bsky.social · 12/10/2025
What is the best brain to study disorders of behavior? Great discussion at @ecnp.eu moderated by @jatinnagpal.bsky.social with inputs from @ribeirocarlitos.bsky.social @emreyaksi.bsky.social @eknapska.bsky.social & Hannah Clarke #ecnp2025
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Surojit Sural @surojitsural.bsky.social · 24/09/2025
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes. www.science.org/doi/10.1126/... Thread ⬇️ (1/n)
science.org
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
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Jatin Nagpal @jatinnagpal.bsky.social · 17/09/2025
Great to see our review on microbiome, exposome and cognitive development out in @annualreviews.bsky.social. @apcmicrobiomeirel.bsky.social @uccresearch.bsky.social #MicrobiomeSky #Gut-Brain
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Atin Sharma @atinsharma.bsky.social · 27/08/2025
Did I just read the best abstract ever? 😁 www.biorxiv.org/content/10.1...
biorxiv.org
Blood, sweat, and beers: investigating mosquito biting preferences amidst noise and intoxication in a cross-sectional cohort study at a large music festival
Introduction We live in a world split between mosquito magnets and those lucky enough to remain (nearly) untouched. The reasons why some people attract more mosquito bites than others remain largely m...
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Jatin Nagpal @jatinnagpal.bsky.social · 21/08/2025
Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits. www.biorxiv.org/content/10.1...
biorxiv.org
Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits
All cells in an animal collectively ensure, moment-to-moment, the survival of the whole organism in the face of environmental stressors. Physiology seeks to elucidate the intricate network of interact...
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Jatin Nagpal @jatinnagpal.bsky.social · 17/08/2025
“Recognising the “New Ireland” means embracing its diversity, not as a problem to manage, but as a strength to celebrate.” Well articulated by Prof. Lokesh Joshi. www.thejournal.ie/readme/racis...
thejournal.ie
Professor: 'It's hard to reassure international researchers about their safety in Ireland'
Professor Lokesh Joshi of University of Galway says recent racist attacks will affect Ireland’s ability to attract world-class researchers.
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Reposted by Jatin Nagpal
David Sancho @sancholab.bsky.social · 16/07/2025
💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky
nature.com
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
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Nature Microbiology @natmicrobiol.nature.com · 16/07/2025
New RESOURCE! Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria @arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co #microbiomesky #microsky www.nature.com/articles/s41...
nature.com
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria - Nature Microbiology
A comprehensive genomic analysis reveals species- and strain-level heterogeneity in carbohydrate utilization potential across bifidobacteria of human origin.
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Reposted by Jatin Nagpal
Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · 16/07/2025
Finally online! Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections. rdcu.be/ewwrG
rdcu.be
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
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Reposted by Jatin Nagpal
John F. Cryan @jfcryan.bsky.social · 07/07/2025
Exciting Senior Scientist 👩‍🔬 👨‍🔬 role available in my research group 🧠 🦠 - Closing date Tuesday 5th August 2025. Please Share @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social Full details here my.corehr.com/pls/uccrecru...
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ScienHub @scienhub-org.bsky.social · 26/06/2025
🧠 How does your gut talk to your brain? We’re diving into the Gut-Brain Axis at #BCNMicrobiome with two leading voices: Jane Foster from #UTSWMedCenter on Microbiome & Depression and @maburto.bsky.social on Microbiota-Brain Communication
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Jatin Nagpal @jatinnagpal.bsky.social · 26/06/2025
Honoured and delighted to join the board of directors at ALBA Network. I look forward to contributing to the ALBA mission to promote equity and inclusion in neuroscience. @ucc.ie @apcmicrobiomeirel.bsky.social @uccresearch.bsky.social
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Pamela Ferretti @pamferretti.bsky.social · 04/06/2025
Interested in microbiome GWAS and heritability studies? Check out our new Review in Nature Reviews Genetics! We explore key findings, challenges, and future directions of the field. rdcu.be/epoRR @blekhman.bsky.social @sambhawa.bsky.social and Dr. Kelsey Johnson.
rdcu.be
Genomics of host–microbiome interactions in humans
Nature Reviews Genetics - In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome...
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Jan Claesen @claesengroup.bsky.social · 24/06/2025
When all this pollution is causing you headaches... 💪🦠
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Reposted by Jatin Nagpal
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 21/06/2025
Exciting fundamental discovery! Early embryos fight bacteria WITHOUT immune cells Zebrafish, mouse, and human embryos use epithelial cells (trophoectoderm)—not immune cells—to engulf and destroy 𝘌. 𝘤𝘰𝘭𝘪 and 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴 Hoijman Lab Barcelona 🇪🇸 𝘊𝘦𝘭𝘭 𝘏𝘰𝘴𝘵 𝘔𝘪𝘤𝘳𝘰𝘣𝘦 www.sciencedirect.com/science/arti...
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Jennifer Biddle @jenbiddle.bsky.social · 19/06/2025
This is so cool - octopus can sense microbiomes: sending a gift link www.nytimes.com/2025/06/17/s...
nytimes.com
Eight Arms to Taste Your Microbiome
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Reposted by Jatin Nagpal
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 15/06/2025
A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain www.biorxiv.org/content/10.1101/202…
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Reposted by Jatin Nagpal
Nature Reviews Immunology @natrevimmunol.nature.com · 12/06/2025
A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease #immunosky #microsky #microbiome
nature.com
A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology
This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...
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Jatin Nagpal @jatinnagpal.bsky.social · 04/06/2025
Microbiome for the clinicians | Cell www.cell.com/cell/fulltex...
cell.com
The microbiome for clinicians
Preclinical studies suggest a rapidly growing potential for the application of microbiome research in improving patient outcomes. This perspective lays out the potential steps that can be taken toward...
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Reposted by Jatin Nagpal
APC Microbiome Ireland @apcmicrobiomeirel.bsky.social · 30/05/2025
Congratulations to APC's @jatinnagpal.bsky.social, @maburto.bsky.social, Koushika Chandrasekaran, Alexandre Cergneux & @drmoralesgarcia.bsky.social - INSPIRE MSCA who have won the Joint @ucc.ie Research Image of the Year for ‘Brain Pipelines’
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Jatin Nagpal @jatinnagpal.bsky.social · 30/05/2025
Delighted to be awarded the joint @uccresearch.bsky.social image of the year for #zebrafish “Brain Pipelines”! Great Team Effort - @maburto.bsky.social, @drmoralesgarcia.bsky.social, Koushika and Alex. @apcmicrobiomeirel.bsky.social, @researchireland.ie, @zebrafishrock.bsky.social
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Jatin Nagpal @jatinnagpal.bsky.social · 22/05/2025
International Booker Prize 2025: Indian author and translators are first to win with a short story collection. www.irishtimes.com/culture/book...
irishtimes.com
International Booker Prize 2025: Indian author and translators are first to win with a short story collection
Banu Mushtaq’s Heart Lamp, translated by Deepa Bhasthi, chronicles the lives of women in southern India
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Jatin Nagpal @jatinnagpal.bsky.social · 21/05/2025
Grateful and proud to be among the 6 candidates on the ballot for joining the ALBA Network Board of Directors. 🗳️ Please vote and advance ALBA's actions for equity and diversity in neuroscience. Details: www.alba.network/elections @ucc.ie @apcmicrobiomeirel.bsky.social @researchireland.ie
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Zebrafish Rock! @zebrafishrock.bsky.social · 18/05/2025
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Segata Lab @cibiocm.bsky.social · 16/05/2025
🥁 NEW: Commentary in @cellcellpress.bsky.social! by @msabrysarhan.bsky.social Giacomo Antonello @whansi.bsky.social @cengoni.bsky.social @dmascalzoni.bsky.social @leviwaldron1.bsky.social Nicola Segata, Christian Fuchsberger www.cell.com/cell/fulltex... 1/4
cell.com
Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat?
Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been ove...
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Jatin Nagpal @jatinnagpal.bsky.social · 17/05/2025
Live bacteria in gut microbiome dictate asthma onset triggered by environmental particles via modulation of DNA methylation in dendritic cells | Cell Reports www.cell.com/cell-reports...
cell.com
Live bacteria in gut microbiome dictate asthma onset triggered by environmental particles via modulation of DNA methylation in dendritic cells
Ramar et al. demonstrate that gut microbiome transplantation confers asthma predisposition elicited by maternal intra-airway exposure to environmental particles. Radiation sterilization or antibacteri...
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Reposted by Jatin Nagpal
Science Magazine @science.org · 14/05/2025
Researchers have found a new ally in the fight against a serious liver disease: a symbiotic gut-dwelling fungus that produces a molecule shown to be capable of reversing disease progression in mice. scim.ag/42ZzVrC
scim.ag
A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis
The gut microbiota is known to be associated with a variety of human metabolic diseases, including metabolic dysfunction–associated steatohepatitis (MASH). Fungi are increasingly recognized as importa...
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Jatin Nagpal @jatinnagpal.bsky.social · 08/05/2025
In utero human intestine contains maternally derived bacterial metabolites | Microbiome microbiomejournal.biomedcentral.com/articles/10....
microbiomejournal.biomedcentral.com
In utero human intestine contains maternally derived bacterial metabolites - Microbiome
Background Understanding when host-microbiome interactions are first established is crucial for comprehending normal development and identifying disease prevention strategies. Furthermore, bacterially...
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Reposted by Jatin Nagpal
Erich Fischer @erichfischer.bsky.social · 07/05/2025
Our children will face unprecedented exposure to weather extremes. Our paper led by Luke Grant and @wimthiery.bsky.social published in @nature.com shows that the generation of our children and grandchildren will be exposed to a lot more weather extremes than ours. www.nature.com/articles/s41...
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Jatin Nagpal @jatinnagpal.bsky.social · 06/05/2025
Gut commensal Phascolarctobacterium faecium retunes innate immunity to mitigate obesity and metabolic disease in mice. | Nature Microbiology www.nature.com/articles/s41...
nature.com
Gut commensal Phascolarctobacterium faecium retunes innate immunity to mitigate obesity and metabolic disease in mice - Nature Microbiology
Gut microbiome member, Phascolarctobacterium faecium, mitigates the inflammatory phenotype associated with obesity by retuning the innate immune response in a mouse model of diet-induced obesity.
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Jatin Nagpal @jatinnagpal.bsky.social · 06/05/2025
Marie Howe wins the 2025 #Pulitzer Prize for poetry. vimeo.com/411239105
vimeo.com
“Singularity (after Stephen Hawking)” by Marie Howe
Poem by Marie Howe. Text and context: https://www.themarginalian.org/2020/04/23/singularity-marie-howe-animated/ Created for The Universe in Verse: https://www.themarginalian.org/the-universe-in-vers...
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Nature Microbiology @natmicrobiol.nature.com · 06/05/2025
🚨 Out now! Chronostrain - a method to profile low abundance strains in longitudinal microbiome samples 🦠💻 @travis.gibsonlab.io @younhk.bsky.social @gibsonlab.io @harvardmed.bsky.social @broadinstitute.org #MicroSky 🦠 #MicrobiomeSky www.nature.com/articles/s41...
nature.com
Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain - Nature Microbiology
ChronoStrain accurately profiles low-abundance strains in longitudinal samples by jointly modelling nucleotide sequencing errors, strain presence/absence and the temporal information associated with e...
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Jatin Nagpal @jatinnagpal.bsky.social · 03/05/2025
A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis. | Science www.science.org/doi/10.1126/...
science.org
A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis
The gut microbiota is known to be associated with a variety of human metabolic diseases, including metabolic dysfunction–associated steatohepatitis (MASH). Fungi are increasingly recognized as importa...
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Jatin Nagpal @jatinnagpal.bsky.social · 03/05/2025
The gut-brain axis mechanism of normal appetite induced by kynurenic acid | Cell Reports www.cell.com/cell-reports...
cell.com
The gut-brain axis mechanism of normal appetite induced by kynurenic acid
Feeding is a fundamental requirement for the survival of host and gut microbiota. Here, Pan et al. discovered how gut microbiota influences feeding behavior through KYNA. During fasting, increased KYN...
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Reposted by Jatin Nagpal
Seye Abimbola @seyeabimbola.bsky.social · 15/11/2024
To mark the centenary of James Baldwin, I wrote a short essay for @TheLancet. On what he's taught me about responding to pushback. To beware of "strategic ignorance" and "the imaginary line of selective judgment". James Baldwin: ignorance, power, justice - www.thelancet.com/journals/lan...
The image is a screenshot of a 2-page article titled James Baldwin: ignorance, power, justice
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Jatin Nagpal @jatinnagpal.bsky.social · 02/05/2025
Global genetic structure of human gut microbiome species is related to geographic location and host health | Cell www.cell.com/cell/fulltex...
cell.com
Global genetic structure of human gut microbiome species is related to geographic location and host health
32,152 gut metagenomes were analyzed, revealing strain-level geographic patterns shaped by horizontal transmission. Microbial phylogenies associate with human phenotypes, including Collinsella clades ...
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Jatin Nagpal @jatinnagpal.bsky.social · 30/04/2025
Diet outperforms microbial transplant to drive microbiome recovery in mice | Nature www.nature.com/articles/s41...
nature.com
Diet outperforms microbial transplant to drive microbiome recovery in mice - Nature
Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions th...
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Reposted by Jatin Nagpal
Julien Tap @julientap.bsky.social · 24/04/2025
Dethlefsen and Relman new #microbiome article is always an event www.nature.com/articles/s41...
nature.com
Brief antibiotic use drives human gut bacteria towards low-cost resistance - Nature
Brief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after exposure a...
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Jatin Nagpal @jatinnagpal.bsky.social · 21/04/2025
Killing the Science Golden Goose | William G. Kaelin, Jr. www.amjmed.com/article/S000...
amjmed.com
Killing the Science Golden Goose
In the 1970’s I was probably one of the last American high school students who was told that if you wanted to go to medical school, you should learn to speak German. This was because in the late 19th ...
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Liz Ortiz de Ora @ortizdeora.bsky.social · 18/04/2025
I am thrilled to share the first manuscript from the Wiles lab! We present "Phollow", an in vivo phage-tagging approach that enables direct observation of phage outbreaks with single-virion resolution by live imaging. Here some highlights 👇 www.nature.com/articles/s41...
nature.com
Phollow reveals in situ phage transmission dynamics in the zebrafish gut microbiome at single-virion resolution
Nature Microbiology - ‘Phollow’ is a live imaging-based fluorescence tagging approach that can track phage replication and spread in situ with single-virion resolution.
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Jatin Nagpal @jatinnagpal.bsky.social · 18/04/2025
Phollow reveals in situ phage transmission dynamics in the #zebrafish gut #microbiome at single-virion resolution | Nature Microbiology doi.org/10.1038/s415...
doi.org
Phollow reveals in situ phage transmission dynamics in the zebrafish gut microbiome at single-virion resolution - Nature Microbiology
‘Phollow’ is a live imaging-based fluorescence tagging approach that can track phage replication and spread in situ with single-virion resolution.
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