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Jakob Grove

@jakobgrove.bsky.social
150 followers 219 following 1 posts

Professor of medical bioinformatics and statistical genetics at Aarhus University

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Reposted by Jakob Grove
Alicia Martin @genetisaur.bsky.social · 08/07/2026
So excited to see this published! This method was a long time in the making and is now being widely used to balance scale with depth, especially for participants where unbiased sequencing approaches are so much more useful than arrays
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Jakob Stegelmann @jakobstegelmann.bsky.social · 24/06/2026
@amnesty.org theintercept.com/2026/06/23/p...
theintercept.com
Prairieland Defendant Sentenced to 30 Years in Prison for Moving a Box of Antifascist Zines
Anti-ICE activists received lengthy prison terms — including a 100-year sentence — in the first major trial of the NSPM-7 era.
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Kristian G. Andersen @kgandersen.bsky.social · 10/06/2026
"One day, American taxpayers might wake up and demand to know why we fund research on baseless conspiracy theories rather than investing in our collective future." This is not some dystopian future, we're already there - question is, will we allow it to continue? www.nytimes.com/2026/06/09/o...
nytimes.com
Opinion | Trump’s Assaults on Scientific Research Just Got Worse
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Michael D. Green, PhD @michaeldgreen.phd · 28/05/2026
President of MIT not mincing words today in @statnews.com www.statnews.com/2026/05/27/s...
So let me say it as clearly as I can: Without basic scientific research, supported by the kind of farsighted public investment that allows large-scale, undirected, curiosity-driven inquiry, the scientific pipeline will run dry.
In daily life, people may not feel the effects right away, or even in 10 years. But we will feel it. And when someone we love needs therapies that could have emerged but didn't or when other countries now
investing in science can launch new science-based industries or run their societies on vast resources of fusion energy or reap the benefits of quantum computing power or advanced medical breakthroughs, America will wish it sustained its leadership in scientific research here and now.
Sally Kornbluth is the president of MIT.
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SMARTbiomed @smartbiomed.bsky.social · 15/05/2026
New full-time postdoc position (32 months) with SMARTbiomed at Aarhus university! Application deadline is June 10th, and all the details can be found at www.au.dk/om/stillinge... - where you can also apply, if you're the one we're looking for!
au.dk
Postdoc in health data science at the Pioneer Centre for SMARTbiomed - Ledig stilling på Aarhus Universitet
Ledig stilling ved Institut for Folkesundhed - Center for Registerforskning, Aarhus Universitet
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 28/04/2026
New autism GWAS incoming! At #INSAR2026, @jakobgrove.bsky.social presented the latest updates on the yet-to-be-released autism GWAS. Curious about the findings? Find them below ⬇️
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Hanbin Lee @epigenci.bsky.social · 30/03/2026
journal website version ! academic.oup.com/genetics/adv...
academic.oup.com
Genetic prediction with ARG-powered linear algebra
Abstract. Ancestral recombination graphs (ARGs) are an attractive means for quantitative genetic analysis of complex traits because they encode the realize
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Huisheng (Julie) Zhu @huishengzhu.bsky.social · 30/03/2026
This work was done in collaboration with my wonderful mentors @yuvalsim.bsky.social , @jeffspence.github.io , @gs2747.bsky.social , and @jkpritch.bsky.social . doi.org/10.64898/202... 🧵2/n
doi.org
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Cedric Boeckx @cedricboeckx.bsky.social · 26/03/2026
Superb resource to study human brain development, out in @nature.com 🧪🧠 An atlas showing how patterns of functional connectivity between brain regions change from birth to old age “Functional hierarchy of the human neocortex across the lifespan” www.nature.com/articles/s41...
nature.com
Functional hierarchy of the human neocortex across the lifespan - Nature
fMRI data from individuals of a wide range of ages (from a few days to 100 years old) are used to map the key organizational axes of functional connectivity in the human cortex throughout the lifespan...
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Kai Sandbrink @ackaisa.bsky.social · 26/03/2026
Excited that my paper on metacontrol in humans and neural networks with @summerfieldlab.bsky.social and @lhuntneuro.bsky.social is out in PNAS! We examine the way that predictive representations of control enable behavioral adaptation across settings, and pathologies: www.pnas.org/doi/10.1073/...
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Hannah Richter @hannah-richter.bsky.social · 11/03/2026
“We were aware that we might have a similar situation this year,” the Ig Nobel founder said after Trump's border policies prompted 4/10 winning teams to decline traveling in 2025. "Then the situation got far worse.” Read about the Igs' decision to move abroad @science.org: tinyurl.com/3kfrdh7y
tinyurl.com
After 35 years, Ig Nobel ceremony to leave the U.S.
Finances and Trump policies underlaid the decision to move the satirical science event to Switzerland
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Dan Søndergaard @dansondergaard.bsky.social · 12/03/2026
We're expanding the compute capacity of GenomeDK significantly! genome.au.dk/news/major-i... Available in Q2 to all new and existing users. @hdsai.sund.ku.dk @au.dk @molbiolau.bsky.social
genome.au.dk
GenomeDK
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Bruce Springsteen @brucespringsteen.net · 28/01/2026
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free
youtu.be
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
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Norm DePlume @normdeplume.bsky.social · 29/01/2026
Hannah Arendt did not mince words, did she? 'Totalitarianism replaces all first-rate talents with crackpots and fools whose lack of intelligence and creativity is still the best guarantee of their loyalty.' From "The Origins of Totalitarianism" (1951)
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Eric Michael Garcia @ericmgarcia.bsky.social · 26/01/2026
You may not know what the Interagency Autism Coordinating Committee is, but it's the central advisory panel for autism in the federal government. @rosebroderick.bsky.social reports that RFK Jr. is loading it up with autism conspiracy theory cranks. www.statnews.com/2026/01/23/k...
statnews.com
Key autism committee is being reshaped to support Kennedy's vaccine agenda, researchers and advocates fear
Researchers and advocates fear a key autism committee is being reshaped to support Kennedy's vaccine agenda.
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Michel Nivard @michelnivard.bsky.social · 06/01/2026
🚨 anyone with methodological skills, an intrest in psychiatric genetics and having impact no psychiatric care should consider this PhD position in Amsterdam with Wouter Peyrot! Its work related to THE first example I give when asked when and how genetics might actually influence care. 🚨
werkenbij.amsterdamumc.org
Vacatures - PhD student: Genetic Prediction in Psychiatry - Amsterdam UMC
Do you want to develop cutting-edge genetic prediction methods to improve early detection of serious mental illness? Join our ERC-funded PhD project and work with large-scale genetic data in an international research team.
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Nature @nature.com · 14/12/2025
Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants go.nature.com/3XM18e7
go.nature.com
Huge genetic study reveals hidden links between psychiatric conditions
Nature - Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants.
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Nature @nature.com · 12/11/2025
Nature research paper: Rare genetic variants confer a high risk of ADHD and implicate neuronal biology go.nature.com/3LARwjy
go.nature.com
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology - Nature
An analysis of rare genetic variants identifies three genes—MAP1A, ANO8 and ANK2—that have a role in attention deficit hyperactivity disorder (ADHD) and investigates the potential underlying biological mechanisms.
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Nature @nature.com · 03/10/2025
Nature research paper: Polygenic and developmental profiles of autism differ by age at diagnosis go.nature.com/3KsKgpj
go.nature.com
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
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Elliot Tucker-Drob @tuckerdrob.bsky.social · 01/10/2025
Non-paywalled link to my commentary on @vw1234.bsky.social and colleagues new paper in @nature.com rdcu.be/eI2NG
rdcu.be
Early- and late-diagnosed autism are genetically distinct | Nature
Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development. Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development.
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Drug Monkey @drugmonkey.bsky.social · 01/10/2025
yep. You can't make a 'better case' that convinces tyranny of the value of science since knowledge is tyranny's kryptonite.
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Jonathan Sebat @sebatlab.bsky.social · 02/10/2025
Please repost: we are recruiting a postdoc for a project in my lab on genes and environment in autism
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Reposted by Jakob Grove
Nature @nature.com · 01/10/2025
The age at which a person is diagnosed with autism can be partly explained by genetic factors go.nature.com/4pQND9E
go.nature.com
Features of autism can affect age of diagnosis – and so can genes
The age at which a person is diagnosed with autism can be partly explained by genetic factors.
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The Guardian @theguardian.com · 01/10/2025
Autism should not be seen as single condition with one cause, say scientists
theguardian.com
Autism should not be seen as single condition with one cause, say scientists
Those diagnosed as small children typically have distinct genetic profile from those diagnosed later, study finds Autism should not be viewed as a single condition with a unified underlying cause, according to scientists who found that those diagnosed early in childhood typically have a distinct genetic profile to those diagnosed later. The international study, based on genetic data from more than 45,000 autistic people in Europe and the US, showed that those diagnosed in early childhood, typically before six years old, were more likely to show behavioural difficulties from early childhood, including problems with social interaction, but remain stable. Continue reading...
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Varun Warrier @vw1234.bsky.social · 01/10/2025
This was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app. Article: www.nature.com/articles/s41...
nature.com
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
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Videnskab.dk @videnskab.dk · 01/10/2025
Autisme: Gener kan påvirke, hvornår diagnosen opdages #dkvid #dkforsk
videnskab.dk
Autisme: Gener kan påvirke, hvornår diagnosen opdages
Sent diagnosticerede har ofte andre psykiatriske lidelser sammen med autisme. En af årsagerne kan være, at de har en særlig genetik, viser ny forskning.
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Nature [Unofficial] @nature.com.web.brid.gy · 23/09/2025
nature.com
Trump links autism and Tylenol: is there any truth to it?
Nature, Published online: 22 September 2025; doi:10.1038/d41586-025-02876-1 The US president repeatedly advised people, “Don't take Tylenol,” but scientists say that strong evidence between the medication and autism is lacking.
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Timothy Snyder @timothysnyder.bsky.social · 20/09/2025
Here is my best guidance, rendered beautifully by the great John Lithgow. I first published these lessons nearly nine years ago, in late 2016. They open the twenty chapters of "On Tyranny: Twenty Lessons from the Twentieth Century." snyder.substack.com/p/twenty-les...
snyder.substack.com
Twenty Lessons, read by John Lithgow
Key selections from On Tyranny, for viewing and sharing
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Miaganga @miaganga.bsky.social · 20/09/2025
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Sam Bagenstos @sbagen.bsky.social · 18/08/2025
"Kennedy would be less hazardous if he decided to do cardiac surgery. Then he would kill people only one at a time rather than his current ability to kill by the thousands." Damn. www.statnews.com/2025/08/18/r... via @statnews.com
statnews.com
Former CDC Director William Foege: How public health can fight back in a time of dangerous nonsense
“Kennedy would be less hazardous if he decided to do cardiac surgery. Then he would kill people only one at a time,” writes former CDC Director William Foege.
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Arseny Khakhalin @khakhalin.bsky.social · 13/08/2025
Somehow them (dictators) destroying the past often feels even more disturbing and depressing than them poisoning the future. The future is malleable, we don't know it yet, there's always hope. Coming for the past may be less immediately impactful, but it does feel as a deeper betrayal
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Kristian G. Andersen @kgandersen.bsky.social · 07/08/2025
Just to give the TL;DR on this one: *The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.
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Jehannine (J9) Austin @j9austin.bsky.social · 26/07/2025
Here’s the “donate” link to save you the time and effort of clicking through: donate.wck.org/give/525879?...
donate.wck.org
World Central Kitchen
{{MetaTags.description}}
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Dan Søndergaard @dansondergaard.bsky.social · 10/07/2025
At GenomeDK, we’re proud to support Danish research and teaching with powerful, flexible computing infrastructure. One of the areas where this really makes a difference is in hands-on teaching environments. Read more here: genome.au.dk/news/ngs-cou...
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Catherine Subsisting in revolting times...Unbelievable @glasscatty.bsky.social · 02/07/2025
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Simon Fisher @profsimonfisher.bsky.social · 21/06/2025
Highly recommend this superb forum article on genomics of human communication traits, free to read in @cp-trendsgenetics.bsky.social. Beautifully succinct & accessible overview by @rosagisladottir.bsky.social on where the field is now & where it's heading. 🗣️💬🧠🧬🧪 www.sciencedirect.com/science/arti...
A screenshot of the first page of a newly published forum article entitled "Advancing GWAS of human communication" authored by Rosa S. Gisladottir in the journal Trends in Genetics. The abstract reads as follows:
The last decade has seen an explosion in genome-wide association studies (GWAS) on almost any imaginable phenotype. Unfortunately, humanity’s most distinctive trait – communication, broadly construed – has been underserved. In this forum article I review recent advances and promising avenues that may help us understand the genetics and evolution of human communication.
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(1/9) 📣 OUT NOW! 📣 So excited to share that our systematic review and meta-analysis on the autism polygenic score is now published in JAACAP Open @jaacapjournals.bsky.social. doi.org/10.1016/j.ja... A (long) thread of our main findings ⤵️
doi.org
Redirecting
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Nature Reviews Genetics @natrevgenet.nature.com · 19/05/2025
ICYMI: New online! Genomics of schizophrenia, bipolar disorder and major depressive disorder
nature.com
Genomics of schizophrenia, bipolar disorder and major depressive disorder
Nature Reviews Genetics, Published online: 12 May 2025; doi:10.1038/s41576-025-00843-0Genomic advances have enhanced our understanding of schizophrenia, bipolar disorder and major depressive disorder, revealing genetic architectures and risk mechanisms through large-scale genome-wide association studies and sequencing, which could address limitations in current diagnostic frameworks and treatment strategies in the future.
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Silvia De Rubeis @derubeislab.bsky.social · 18/05/2025
🧪 New paper alert! In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠 www.nature.com/articles/s41...
nature.com
Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X - Nature Communications
Genetic mutations in the DDX3X gene are associated with a neurodevelopmental disorder primarily affecting females. Here authors show that Ddx3x mediates sexual dimorphisms during brain development at ...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 16/05/2025
📣Out now 📣 In a GWAS meta-analysis, @angelicaronald.bsky.social and colleagues identified 11 independent genome-wide significant loci associated with age at onset of walking. www.nature.com/articles/s41...
nature.com
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
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Abdel Abdellaoui @dr-appie.bsky.social · 13/05/2025
Check out our new OCD GWAS (53,660 cases and 2,044,417 controls) in @natgenet.nature.com 🧬🧠 Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia. Open access: www.nature.com/articles/s41...
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Laurits Skov @lauritsskov.bsky.social · 05/05/2025
We ( @zeniabaek.bsky.social @moicoll.bsky.social and @asgerhobolth.bsky.social ) present a new cool way to visualize the optimal trade off for hmm decoding called Artemis plots! arxiv.org/pdf/2504.15156 www.biorxiv.org/content/10.1...
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Mikkel Heide Schierup @mikkelschierup.bsky.social · 04/05/2025
Come join us at the Bioinformatics Research Centre at Aarhus University. Tenure track/associate professor position available with application deadline June 1, 2025. Application details here: international.au.dk/about/profil...
international.au.dk
Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University
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skouped.bsky.social @skouped.bsky.social · 02/05/2025
I have two open postdoc positions in generative AI and blood-based cancer detection (application deadline: 25 May 2025). Learn more and apply here: health.au.dk/en/about-hea... #GenerativeAI #ctDNA #Bioinformatics #DataScience #StatisticalMethods #CancerResearch #Nucleosome
health.au.dk
Two postdoctoral positions in generative AI modeling for blood-based cancer detection - Vacancy at Aarhus University
Vacancy at Department of Clinical Medicine - Department of Molecular Medicine (MOMA), Aarhus University
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Varun Warrier @vw1234.bsky.social · 29/04/2025
Many thanks to our wonderful collaborators @raibethlehem.bsky.social , @sofievalk.bsky.social @wanb.bsky.social @jakobgrove.bsky.social and many others not on this app.
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Kevin Mitchell @wiringthebrain.bsky.social · 25/04/2025
Seems like we have the same collective amnesia about fascism as we do about measles. Cuz we haven’t seen it in a few generations, we’ve forgotten that we need to protect ourselves against it.
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Varun Warrier @vw1234.bsky.social · 22/04/2025
Pleased to share our recent work led by Raphael Bourque where we ask if it's possible to predict co-occurring intellectual disability among autistic individuals using genetic and developmental data. Early identification of these children may be useful for targeted support. bit.ly/4jFY5Nh
jamanetwork.com
Genomic Models to Predict Outcomes in Autistic Children
This prognostic study evaluates the predictive performance of combining genetic variants and developmental milestones to predict intellectual disability in autistic children.
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Robert Reich @rbreich.bsky.social · 12/04/2025
The United States is the richest country in the history of the world. But who benefits from those riches? Consider: the richest 10% of Americans hold nearly 70% of the nation’s wealth – while the bottom 50% hold just 3%. See the problem?
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