The annual turquoise killifish (Nothobranchius furzeri) cone photoreceptor mosaic is an ordered lattice but lacks regularity of cone subtypes in adulthood. The cone mosaic differs between life stages...

Biologists at the Flatiron Institute’s Center for Computational Biology used mathematical models to improve our understanding of sperm structure and function.

European Research Council funds research project on physical foundation for sequence-guided genome organization with 2.5 million euros

Researchers have catalogued dozens of new marine species found in the depths of Australia's most remote waters. The result is a window into a rarely glimpsed world.

Optimal neural processing relies on precise tissue patterning across diverse cell types. Here, we show that spontaneous calcium waves arise among non-neuronal support cells in the developing Drosophil...

Interview with Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard Univ...

Nature Reviews Molecular Cell Biology, Published online: 11 November 2025; doi:10.1038/s41580-025-00917-1The ability to track single cells in vivo, combined with insights into chromatin structure, immune–tissue crosstalk, bioelectric and metabolic cues and quantitative modelling, is changing our understanding of how tissues are repaired and renewed. This Review discusses how signals are regulated during regeneration and future directions for a more quantitative understanding of regenerative biology.

The generation of a periodic body plan is a fundamental property of vertebrates. While biological oscillators provide a mechanism for timing the formation of repeated structures, few examples of signa...

The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attempts to exhaustively tabulate the interactions within d...

How do vascular tissues grow with the rest of the developing organism postnatally? In this issue of Cell Systems, Pi et al. combine modeling with molecular biology to uncover how cell behaviors scale ...

The two-week-long Symbiosis program yielded six experimental short films about basic science.

During development, cells must interpret extracellular signals with speed and accuracy. While morphogen gradients pattern tissues, how cells respond to dynamic morphogens remains unclear. Here, we inv...

A model for the generation of a cell fate pattern via a coupling between mechanical stress and cell fate is presented. $I\phantom{\rule{0}{0ex}}n$ $v\phantom{\rule{0}{0ex}}i\phantom{\rule{0}{0ex}}t\ph...

An exploration of how artificial intelligence is changing what it means to do science and math, and what it means to be a scientist.

A conserved feature of metazoan meiosis is that it occurs in a syncytium. Here, the authors show that intercellular bridges that connect germ cells in a syncytium are critical for ensuring proper meio...

A Flatiron Institute scientist has developed the first analytical model for predicting how bacteria spread in environments filled with obstacles.

We address the problem of explaining the decision process of deep neural network classifiers on images, which is of particular importance in biomedical datasets where class-relevant differences are no...