A huge congratulations to Zheng and the entire Guo lab for this beautiful story! Very cool mechanism!
www.nature.com/articles/s41...
nature.com
Intestinal stem cells count self-renewal divisions to switch multipotency - Nature
In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...