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Samuel Sledzieski

@samsl.io
779 followers 256 following 73 posts

Research Fellow @flatironinstitute.org @simonsfoundation.org Formerly @csail.mit.edu @msftresearch.bsky.social @uconn.bsky.social Computational systems x structure biology | he/him | samsl.io | 👨🏼‍💻

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Reposted by Samuel Sledzieski
pilarcossio.bsky.social @pilarcossio.bsky.social · 14h
*Job alert*: Postdoc position at the Flatiron Institute to work on biophysical inference and cryo-EM. ❄️ 🔬Applications are welcome! apply.interfolio.com/193799
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Reposted by Samuel Sledzieski
Matt Norlander @norlander.bsky.social · 28/09/2026
One of the most revered and celebrated albums in music history was released on Sept. 28, 1976 — 50 years ago today. Songs in the Key of Life tracks, ranked:
Vinyl copy1. Sir Duke
2. As
3. Contusion
4. Another Star
5. Have a Talk With God
6. I Wish
7. Love’s in Need of Love Today
8. Summer Soft
9. Black Man
10. Pastime Paradise
11. Ordinary Pain
12. Isn’t She Lovely
13. Ngiculela
14. Village Ghetto Land
15. Joy Inside My Tears
16. Knocks Me Off My Feet
17. If It’s Magic
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Rob Patro @robp.bsky.social · 25/09/2026
Ok comp. bio / bioinformatics / genomics friends. Let's talk about @recombconf.bsky.social and, specifically, the way in which the "proceedings" have evolved. This seems like something that we, as a community, should address. RECOMB now has no "published" proceedings in the classic sense.
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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Niema Moshiri @niema.net · 17/09/2026
My department is hiring an Assistant Professor! Come join us at @ucsandiego.bsky.social Computer Science & Engineering! Beautiful city, awesome colleagues, delicious tacos 😄 apol-recruit.ucsd.edu/JPF04649
apol-recruit.ucsd.edu
Assistant Professor - CSE
University of California, San Diego is hiring. Apply now!
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Sukrit Singh @sukritsingh92.bsky.social · 15/09/2026
📣 The Singh Lab opens at Fox Chase Cancer Center in Spring 2027, where I will be starting as an Assistant Professor!📣 Excited to continue studying how protein biophysics shapes drug response. I am hiring across all levels and disciplines! Apply on the "Join" page ( & spread the word!): singhlab.bio
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kate @katewitko.bsky.social · 19/08/2026
[steely dan voice] 8/19
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Niema Moshiri @niema.net · 13/08/2026
Our department is hiring an Adjunct Professor at all ranks! apol-recruit.ucsd.edu/JPF04582
apol-recruit.ucsd.edu
Assistant, Associate or Full Adjunct Professor
University of California, San Diego is hiring. Apply now!
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Reposted by Samuel Sledzieski
Max Fürst @maxfus.bsky.social · 11/08/2026
Extraordinary blog post by @moalquraishi.bsky.social moalquraishi.wordpress.com/2026/08/10/a... Starting with the question on whether workaphiles will be dying breed post AGI, it later turns into serious scifi - "The 'easy' solution is to make our brains bigger"
moalquraishi.wordpress.com
A Workaphile’s Apology
Disclaimer: No LLMs were used in the writing of this essay—all em dashes are mine1. Soon after the AlexNet breakthrough burst onto the scene over a decade ago, I became preoccupied with the followi…
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Reposted by Samuel Sledzieski
Jason Nomburg @jnoms.bsky.social · 22/07/2026
Ad forthcoming, but I am hiring for a postdoc or staff scientist to advance related investigations of the virus-host conflict. This position is ~80-100% computational, but with opportunities for experimental work if desired. If interested, shoot me an email with your CV! Reposts appreciated! 15/15
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Nicholas Grossman @nicholasgrossman.bsky.social · 18/07/2026
The US built the greatest talent magnet ever, attracting the smart, skilled, and striving. They’d come to study, then stay and build things here, or leave with positive impressions and fruitful connections. Helped make the US wealthy and powerful. Then America chose to throw it away. And for what?
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Samuel Sledzieski @samsl.io · 15/07/2026
I'm giving a poster on MIMIC at #ISMB2026 today (C-211)! Drop by and chat with me about multimodal modeling for DNA, RNA, and protein biology. Inference code + checkpoints + sample data are all now available on GitHub/HuggingFace. github.com/PolymathicAI...
github.com
GitHub - PolymathicAI/MIMIC: A Generative Multimodal Model for Biomolecules
A Generative Multimodal Model for Biomolecules. Contribute to PolymathicAI/MIMIC development by creating an account on GitHub.
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Magnus Bauer @kinasekid.bsky.social · 14/07/2026
Can we program a kinase like a switch? Inspired by natural autoinhibitory complexes, we designed miniproteins against active- and inactive-like conformations of Focal Adhesion Kinase. Depending on the targeted state, the resulting binders either activated or inhibited the kinase.
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Yun S. Song @yun-s-song.bsky.social · 06/07/2026
I am thrilled to share that UC Berkeley and UCSF have launched a joint initiative in Computational Biomedicine! cdss.berkeley.edu/news/uc-berk... We will soon be recruiting new faculty and postdoctoral fellows. Please repost to help spread the word.
cdss.berkeley.edu
UC Berkeley and UCSF Launch Computational Biomedicine Initiative
UC Berkeley and UCSF have launched a joint program called the Bakar Computational Biomedicine Initiative to develop the frontier of AI and biomedicine, tremendously accelerating advances in clinical c...
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Reposted by Samuel Sledzieski
Wandering Scientist @wandsci.bsky.social · 30/05/2026
My go to example of this sort of thing is the study of weird thermophilic bacteria gave us PCR, upon which so much of modern biological research and its many applications (including drug discovery!) depend
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 30/05/2026
Everything you wanted to know about the protein chemistry behind how amino-acid changes affect the cellular abundance of proteins from @tkschulze.bsky.social Effects of residue substitutions on the cellular abundance of proteins doi.org/10.7554/eLif...
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EMBL-EBI @ebi.embl.org · 28/05/2026
We told you it wouldn’t be a long wait. 👀 Even more predicted protein structures have been added to the #AlphaFold Database. This time, the database has expanded to include heterodimers – protein complexes made up of two different proteins. alphafold.ebi.ac.uk
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Samuel Sledzieski @samsl.io · 28/04/2026
Introducing MIMIC: a new foundation model trained natively across DNA, RNA and proteins. MIMIC is multimodal and generative: it can use structure, regulation, evolution, and experimental context to infer missing biology or design new sequences. 🧵⬇️
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Miro Astore @miroastore.bsky.social · 24/04/2026
We just preprinted one of my favorite studies @FlatironInst . I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
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Samuel Sledzieski @samsl.io · 02/04/2026
Our review on ML for modeling conformational ensembles is out now in Current Opinion in Structural Biology (w/ @sonyahanson.bsky.social)! It's been exciting to follow all the progress in this field recently, and I'm equally excited to see where it goes! www.sciencedirect.com/science/arti...
sciencedirect.com
The landscape of machine learning approaches for modeling protein conformational ensembles
The conformational ensemble of a protein and its corresponding probabilities and dynamics are crucial determinants of its function, but are difficult …
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Matt Norlander @norlander.bsky.social · 30/03/2026
ONE OF THE BIGGEST SHOTS AND CRAZIEST MOMENTS IN CBB HISTORY
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cryoEM papers @cryoempapers.bsky.social · 20/03/2026
StrucTTY: An Interactive, Terminal-Native Protein Structure Viewer www.biorxiv.org/content/10.64898/2026.03.17.712308v1 #cryoEM
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Michael Baym @baym.lol · 17/03/2026
Annual reminder: if you’ve been accepted to multiple graduate programs and are still deciding, please let the ones you’re definitely not going to know as soon as possible! -Someone who got into his PhD off the waitlist the day after the deadline
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 17/03/2026
AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk
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EMBL-EBI @ebi.embl.org · 16/03/2026
You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database. This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list. www.ebi.ac.uk/about/news/t...
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Samuel Sledzieski @samsl.io · 11/03/2026
Had a lot of fun working on this with Darius, Christian, and Rohit. We address the problem of unpredictable scaling behavior for PLMs -- with a simple 2-line drop-in replacement for ESM2, you no longer need to worry that a smaller model might end up performing better! 🧵⬇️
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Pedro Beltrao @pedrobeltrao.bsky.social · 04/03/2026
We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations. www.evocellnet.com/2026/03/mapp...
evocellnet.com
Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration
We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...
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Andre Cornman @ancornman1.bsky.social · 03/03/2026
Predicting protein-protein interactions (PPIs) at proteome scale can take months with co-folding models due to the massive all-vs-all comparisons required. We are excited to announce FlashPPI, a contrastive learning framework that predicts proteome wide physical interfaces in minutes. 1/🧵
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Mayor Zohran Kwame Mamdani @mayor.nyc.gov · 28/02/2026
Additionally, I want to speak directly to Iranian New Yorkers: you are part of the fabric of this city — you are our neighbors, small business owners, students, artists, workers, and community leaders. You will be safe here.
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Sonya @sonyahanson.bsky.social · 22/02/2026
A great start to the Biophysical Society Annual Meeting in San Francisco! Check out the various projects being presented on work from Flatiron Institute people! #bps2026
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Patrick Bryant @patrickbryant1.bsky.social · 07/02/2026
Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure. We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)
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Samuel Sledzieski @samsl.io · 03/02/2026
Looking forward to speaking to @jhucompsci.bsky.social and JHU Biomedical Engineering this Thursday!
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 30/01/2026
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...
science.org
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
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sam @samthielman.com · 22/01/2026
I just thought everyone should see this
Dr Kareem Carr
man: i wish to publish
@kareem_carr
Jan 21
reviewer 2: your paper is no good
man: i'll do anything to improve
reviewer 2: it's simple. you must read the work of the great scientist Pagliarini
man: *bursts into tears* but i am Pagliarini
Andre Pagliarini
@apagliar
Jan 21
a first: in rejecting an article I submitted to a journal, reviewer 2 noted I failed to engage the work of one Andre Pagliarini
Jan 21, 2026 • 3:47 PM UTC
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Milot Mirdita @milot.bsky.social · 20/01/2026
My time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring! mirdita.org
mirdita.org
Mirdita Lab - Laboratory for Computational Biology & Molecular Machine Learning
Mirdita Lab builds scalable bioinformatics methods.
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Minhuan Li @minhuanli.bsky.social · 02/01/2026
Check our new preprint smoothing rugged Cryo-EM landscapes: shorturl.at/gYs9U We tackle practical hurdles of Optimal Transport (OT) loss—differentiability, cost & noise sensitivity—make it a feasible inference workhorse. W/ G. Woollard, D. Herreros, @pilarcossio.bsky.social, K. Dao Duc 🧵👇 (1/9)
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Samuel Sledzieski @samsl.io · 07/01/2026
🌿 MINT is out now in Nature Communications! 📄: www.nature.com/articles/s41... 💻: github.com/VarunUllanat...
nature.com
Learning the language of protein-protein interactions - Nature Communications
Protein language models capture single proteins but struggle with interactions. Here, authors present MINT, trained on large PPI datasets, which outperforms existing PLMs in predicting binding, mutati...
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Rodger Sherman @rodger.bsky.social · 19/12/2025
Terrifying headline if you don’t realize they are sports teams.
Rockets owners expand talks to buy, move Sun
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Hayden Nunley @haysconun.bsky.social · 11/12/2025
The Center for Computational Biology at the Flatiron Institute is accepting applications for summer intern positions. CCB is a great place to work, and the intern program is excellent. Please check out the Computer Vision and Developmental Dynamics groups in particular. apply.interfolio.com/177779
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Samuel Sledzieski @samsl.io · 01/12/2025
We're recruiting summer interns at all levels (Bachelors, Masters, PhD) and across all groups at @flatironinstitute.org Center for Computational Biology. Come work with us in New York City! (Full-time paid, June 1-August 14 2026, applications close January 16 2026) apply.interfolio.com/177779
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Sonya @sonyahanson.bsky.social · 07/11/2025
Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/challenge #cryoem
heterogeneity.notion.site
CAHRA 2025: Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms
A community-wide data processing challenge for cryo-electron microscopy.
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pilarcossio.bsky.social @pilarcossio.bsky.social · 22/10/2025
**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org
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Samuel Sledzieski @samsl.io · 12/10/2025
D-SCRIPT + BMPI is out today in Bioinformatics! academic.oup.com/bioinformati...
academic.oup.com
Memory-Efficient, Accelerated Protein Interaction inference with Blocked, Multi-GPU D-SCRIPT
AbstractSummary. D-SCRIPT is a powerful tool for high-throughput inference of protein-protein interactions (PPIs), but it is expensive in time and memory t
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 02/10/2025
Integrative modelling of biomolecular dynamics Time-dependent and -resolved experiments combined with computation provide a view on molecular dynamics beyond that available from static, ensemble-averaged experiments Review w @dariagusew.bsky.social & Carl G Henning Hansen doi.org/10.48550/arX...
Figure 1 from the review. Caption: Comparison of a schematic example showing static, time-dependent, and time-resolved experiments illustrated by a protein folding process. (a) A static experiment measuring the observable O$_{\text{exp}}$ is shown, which can be modelled as a distribution of simulated values, O$_{\text{calc}}$, representing a conformational ensemble of folded and unfolded states. (b) Shows a time-dependent experiment, where the equilibrium dynamics of reversible folding gives rise to measured transition times $\tau_1$ and $\tau_2$. These can be modelled as equilibrium dynamics, illustrated by a free energy (FE) surface along a chosen degree of freedom (D.O.F.) (c) A time-resolved experiment probes a non-equilibrium process, where the system begins at $t_{0}$ in the folded state. During the observation time $t$ the protein unfolds until $t_{\text{max}}$. At each time point, a distinct ensemble average, O$_{\text{exp}}$, can be observed, reflecting the proteins changing structure. This evolution can be modelled as distributions of O$_{\text{calc}}$ at each time point. These are shown together with a FE surface.
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Rodger Sherman @rodger.bsky.social · 02/10/2025
These are the quarterbacks since 2010 who complete passes at roughly the rate Microsoft Excel’s AI mode accurately edits spreadsheets
Jake Locker
Davis Webb
Tom Savage
Rex Grossman
Garrett Gilbert
Kellen Clemens
Mark Sanchez
Logan Woodside
Zach Wilson
David Blough
Derek Anderson
Johnny Manziel
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pilarcossio.bsky.social @pilarcossio.bsky.social · 19/09/2025
*Job Alert*: postdoc positions available @flatironinstitute.org in Computational Mathematics: apply.interfolio.com/173401
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Barış Ekim @ekimb.bsky.social · 16/09/2025
Happy (a^2, b^2, c^2)! www.npr.org/2025/09/16/n...
npr.org
On 9/16/25, celebrate a date of mathematical beauty
Pythagorean Triple Square Day, as one man affectionately calls 9/16/25, is a day like no other this century.
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David A Knowles @davidaknowles.bsky.social · 10/09/2025
YouTube link for MLCB2025 is up! Starting in 30 min. www.youtube.com/live/19I7xTh...
youtube.com
Machine Learning in Computational Biology 2025
YouTube video by Machine Learning in Computational Biology
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Samuel Sledzieski @samsl.io · 10/09/2025
I’ll be at MLCB today and tomorrow, and talking about our latest work on modeling protein dynamics 🚀 tomorrow afternoon!
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Peter Koo @pkoo562.bsky.social · 10/09/2025
2025 Machine Learning in Computational Biology (#MLCB) meeting starts TODAY (9/10) at 9:30a (EST) at the NY Genome Center in NYC! We have a great lineup of keynotes, contributed talks, and posters today and tomorrow Schedule: mlcb.org/schedule Join for free via livestream: m.youtube.com/@mlcbconf
mlcb.org
MLCB - Schedule
The in-person component will be held at the New York Genome Center, 101 6th Ave, New York, NY 10013. All times below are Eastern Time.
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