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Biomolecular condensates are central to subcellular compartmentalization and RNA regulation. In the multinucleate fungus Ashbya gossypii, condensates composed of Whi3 protein and CLN3 mRNA help ensure...

BY ADRIANA V. DIFRANCO What do fungi in the forest and human placentas have in common? It sounds like a riddle, but it’s actually a fascinating biological conundrum. Fungi and placentas have two of th...

Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

Following the “Integrating Cell and Planetary Scales to Address Climate Resilience” workshop held in Lisbon in April 2025, we’re launching a new community dedicated to bridging scientific disciplines ...

Localization of the septin cytoskeleton is controlled by regulatory factors, membrane curvature, and charge. In this study, changes to lipid composition th

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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The molecular and cellular biology community has always been driven by a fascination with mechanisms – how proteins interact, how organelles communicate and how cells respond to stimuli. Yet one of th...

Biomolecular condensates mediate diverse and essential cellular functions by compartmentalizing biochemical pathways. Many condensates have internal subdomains with distinct compositional identities. ...

Cells employ cytoskeletal polymers to move, divide, and pass information inside and outside of the cell. Previous work on eukaryotic cytoskeletal elements such as actin, microtubules, and intermediate...

Septins assemble into scaffolds that direct cell growth and morphology that are often localized to the plasma membrane. While septins preferentially bind convex membranes via amphipathic helices, thei...

The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…

This course is at the forefront of new tools — molecular, computational, biophysical — as it prepares students to tackle emerging biological questions.

The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…

Morphogenesis in fungi and animals is directed by polarization of small GTPases Cdc42 and Rac. In the budding yeast Saccharomyces cerevisiae competition between polarity patches results in one polariz...

Most amino acids are encoded by multiple codons, making the genetic code degenerate. Synonymous mutations affect protein translation and folding, but their impact on RNA itself is often neglected. We ...

Coordination between growth and division is a fundamental feature of cells. In many syncytia, cell growth must couple with multiple nuclear divisions in one cytoplasm. In the fungus, Ashbya gossypii, ...