Nature Reviews Genetics, Published online: 08 September 2026; doi:10.1038/s41576-026-01004-7Programmed DNA elimination is a developmentally regulated process in which specific DNA sequences are reproducibly removed from particular cell lineages. Here, the authors review the mechanistic diversity and evolutionary dynamics of DNA elimination, spanning chromosome breakage, whole-chromosome elimination and whole-genome elimination.

Animal fertility and germ cell genome integrity is protected by the Piwi-interacting RNA (piRNA) pathway. While germline development unfolds through profoundly different chromatin and transcriptional ...

The 2027 Gordon Research Conference on Epigenetics will be held in Holderness, New Hampshire. Apply today to reserve your spot.

Chez les eucaryotes, la marque épigénétique H3K27me3 est classiquement associée à la répression transcriptionnelle.

Abstract. While genome-wide analyses in vertebrates suggest that transcription negatively regulates replication origin activation, thereby shaping the land

Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...

In a dividing cell, chromosome pairs are pulled apart thanks to attachment sites called centromeres. Yeast genomes reveal key steps in how centromeres have evolved. In a dividing cell, chromosome pairs are pulled apart thanks to attachment sites called centromeres. Yeast genomes reveal key steps in how centromeres have evolved.

Background The role of transposable elements (TEs) in host adaptation has gained interest in recent years. Individuals of the same species undergo independent TE insertions, providing genetic variabil...

DNA replication in multicellular organisms follows a tightly regulated spatio-temporal program. Although the mechanisms underlying this replication program remain only partially understood, studies in...

Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler

Nature Reviews Molecular Cell Biology - A study that showed that programmed DNA elimination in somatic genomes of ciliates involves excision of intrusive, transposon-derived sequences from genes.

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...

Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...

The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involvin...

Background. Paramecia belong to the ciliate phylum of unicellular eukaryotes characterized by nuclear dimorphism. A diploid germline micronucleus (MIC) transmits genetic information across sexual gene...

Nature Communications - Here, the authors investigate chromatin-based gene regulation in the closest relative of animal, choanoflagellates. They uncover a putative dual role for the histone...

Abstract. To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms

Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...