Faithful chromosome segregation during meiosis I requires tight control of interhomolog recombination. In budding yeast, the meiotic chromosome axis, built on Rec8-containing cohesin together with Red...

Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

YouTube video by Stowers Institute for Medical Research

Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...

The new website of the Ensembl project

Argonaute proteins are best known for their role in microRNA-mediated post-transcriptional gene silencing. Here, we show that AGO3 and AGO4, but not AGO2, localize to the sex chromatin of pachytene sp...

Most extant eukaryotic systems share core meiosis-specific genes, suggesting meiosis evolved only once in the last eukaryotic common ancestor (LECA). These genes have been characterized as master regu...

Crossing over between homologous chromosomes in meiosis is essential in most eukaryotes to produce gametes with the correct ploidy. Meiotic crossovers are typically evenly spaced, with each homolog pa...

The dated genetics taught in U.S. schools stokes misconceptions about race and human diversity. A biological anthropologist calls for change.

An Owner's Guide to the Human Genome

<p>The Symposium will showcase transformative, fundamental research in Human Genetics for a broad audience of biologists and biomedical researchers. To this end, we bring together an interdisciplinary...

Using five complementary short- and long-read sequencing technologies, we phased and assembled >95%

Meiotic recombination is a fundamental process that generates genetic diversity by creating new comb

Homologous recombination rearranges genetic information during meiosis to generate new combinations

Evidence from the corn snake suggests that PR domain zinc finger protein 9 may not act alone to specify recombination hotspots in all species.

Crossing-over between homologous chromosomes is essential for accurate segregation during meiosis. I