iiinova — where your digital self keeps evolving

Reposted by Mahsa Mofidi

Samuel Sledzieski @samsl.io · 28/04/2026

Introducing MIMIC: a new foundation model trained natively across DNA, RNA and proteins. MIMIC is multimodal and generative: it can use structure, regulation, evolution, and experimental context to infer missing biology or design new sequences. 🧵⬇️

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Reposted by Mahsa Mofidi

Miro Astore @miroastore.bsky.social · 24/04/2026

We just preprinted one of my favorite studies @FlatironInst . I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...

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Mahsa Mofidi @mahsamofidi.bsky.social · 29/04/2026

All-atom MD shows how septin amphipathic helices bind lipid bilayers and interact cooperatively. We observe a curved “smile-like” bound helix and sequential anti-parallel AH–AH contacts, suggesting a mechanism for cooperative recruitment/assembly. #Septins #MD #CompBio dx.plos.org/10.1371/jour...

dx.plos.org

Study of Protein-Protein Interactions in Septin Assembly: Multiple amphipathic helix domains cooperate in binding to the lipid membrane

Author summary Cells sense and respond to their shape in order to grow, divide, and organize internal structures. Septins are a family of proteins that help cells detect membrane curvature, allowing t...

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Reposted by Mahsa Mofidi

Samuel Sledzieski @samsl.io · 15/02/2025

I'm at @biophysicalsoc.bsky.social #BPS2025 with a bunch of folks from the Structural and Molecular Biophysics @flatironinstitute.org group-- come say hi and check out our posters/talks! @sonyahanson.bsky.social @pilarcossio.bsky.social @miroastore.bsky.social

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