Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

Summary: The placenta is the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. This Review highlights its high mutational load, structural variants, aneupl...

Proportional organ growth requires tissue-level control of cell behavior. Yet the cues that adapt growth rates, especially after organ injury, remain unclear. Here, we uncover that developing organs a...

Modern amphibians are characterized by an aquatic larval stage that ends abruptly with a period of widespread tissue remodeling (metamorphosis) upon transition to terrestrial adulthood. A transient la...

Imaging spotlight - How to divide without a ring: a mechanical ratchet drives unilateral cytokinesis - News

A small tissue fold present in fruit fly embryos buffers mechanical stresses and may have evolved in response to mechanical forces.

Biomolecular condensates are made of multiple components but current techniques cannot capture their complex composition quantitatively. Now it has been shown that the dense-phase binodal point defini...

This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

Xu et al. investigate how the speed of chromosome separation is regulated during the cleavage divisions of the Drosophila blastoderm. They find that spindle length and the cell cycle oscillator jointly control the velocity of chromosome movement in anaphase.

In the embryo, morphogenetic signals instruct regional patterning thereby defining the body axes of the future animal. Remarkably, in the absence of such signals, collections of pluripotent stem cells...