Therapeutics; cancer; transcriptomics

Summary: Amoeboid cancer cells exploit actomyosin contractility, metabolic adaptability and immune evasion to drive metastasis, representing a distinct and therapeutically targetable state within the ...

Targeting AMPK as a metabolic vulnerability of metastatic cancer cells

Graziani et al. show that SLC7A11 increases during melanoma disease progression. SLC7A11 promotes Myosin II-driven amoeboid invasive behavior while shielding amoeboid cancer cells from oxidative stres...

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Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell in...

Scientists discover the ‘roadmap’ that aggressive cancer uses to spread around the body – identifying ways to block its escape

For the past 20 years, CellMech has brought together physicists, biologists, engineers, and mathematicians to discuss the advancements in cellular mechanobiology. The 2025 edition, to be held in…

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