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Miro Astore

@miroastore.bsky.social
456 followers 533 following 37 posts

Postdoc @rockefeller. Making cryoEM into a tool for RNA biophysics one molecule at a time.

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Miro Astore @miroastore.bsky.social · 27/04/2026
Responses to this work have been great. I want to specifically highlight the contributions of Robert Clark tinyurl.com/5dmm5yns. He started this project as an intern and made it into a rigorous study. He's starting to look for postdocs and I cant recommend him highly enough. Please reach out to him!
tinyurl.com
Have a look at my paper! I have had an amazing time working on this and I'm really proud of the outcome. I want to say thank you in particular to Miro Astore, Sonya Hanson and Pilar Cossio for the...
Have a look at my paper! I have had an amazing time working on this and I'm really proud of the outcome. I want to say thank you in particular to Miro Astore, Sonya Hanson and Pilar Cossio for the int...
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Miro Astore @miroastore.bsky.social · 24/04/2026
We just preprinted one of my favorite studies @FlatironInst . I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
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Miro Astore @miroastore.bsky.social · 22/02/2026
Cannot recommend the talk by Louis Smith enough. It's been such an amazing project!
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Miro Astore @miroastore.bsky.social · 10/02/2026
Really neat math that I use a lot. Well done @pilarcossio.bsky.social, Wai Shing, Jeff and Adi!
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Michael O’Brien @m0bri3n.bsky.social · 06/02/2026
It’s been fun to put together and write up cryoJAX. Hooray for open-source cryo-EM software! Now it’s time to use it…
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Miro Astore @miroastore.bsky.social · 04/02/2026
Go use cryojax ! It's awesome! I can't wait to see what people do with it.
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Structural Biology @actacrystd.iucr.org · 20/01/2026
Alexandre G. Urzhumtsev: Quantifying distributions of cryo-EM projections #CryoEM #AngularDistributionOfViews #NonUniformDistribution ... #IUCr journals.iucr.org/paper?S2059798325…
journals.iucr.org
Quantifying distributions of cryo-EM projections
We propose a numerical measure to quantify the deviation of a distribution of cryo-EM 2D views from the uniform distribution. This approach allows the traditional two-dimensional projection diagrams to be complemented with quantitative characteristics and simple, easily generated curves that are straightforward to analyze.
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cryoEM papers @cryoempapers.bsky.social · 25/11/2025
The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge pubmed.ncbi.nlm.nih.gov/41280101/ #cryoEM
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cryoEM papers @cryoempapers.bsky.social · 20/11/2025
CryoLike: a Python package for cryo-electron microscopy image-to-structure likelihood calculations pubmed.ncbi.nlm.nih.gov/41258998/ #cryoEM
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Miro Astore @miroastore.bsky.social · 14/11/2025
Hello world! It's been a true joy to work on this with Michael. Both him and cryoJAX are things to keep an eye on. They're going to make amazing things happen in cryo and beyond.
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cryoEM papers @cryoempapers.bsky.social · 25/10/2025
CryoJAX - A Cryo-Electron Microscopy Image Simulation Library in JAX www.biorxiv.org/content/10.1101/2025.10.23.682564v1 #cryoEM
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Oli Clarke @olibclarke.bsky.social · 13/09/2025
This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x
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Miro Astore @miroastore.bsky.social · 14/09/2025
I'm very excited to announce that I've just joined Steve_Bonilla's lab at @rockefelleruniv.bsky.social. With the help of @pilarcossio.bsky.social and colleagues at @flatironinstitute.org. I'll be developing cryoEM into a quantitative method to study RNA biophysics.
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Khaled_Selim Lab @selimlab.bsky.social · 24/07/2025
The results of the first #cryoEM heterogeneity challenge are up on biorxiv! www.biorxiv.org/content/10.1...
biorxiv.org
The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge
Despite the rise of single particle cryo-electron microscopy (cryo-EM) as a premier method for resolving macromolecular structures at atomic resolution, methods to address molecular heterogeneity in v...
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Miro Astore @miroastore.bsky.social · 23/07/2025
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv! biorxiv.org/content/10.110
biorxiv.org
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Miro Astore @miroastore.bsky.social · 30/03/2025
Super excited for this one! Great job guys.
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Lander Lab @landerlab.bsky.social · 19/03/2025
That’s a wrap on the 2025 Cold Spring Harbor CryoEM course! Huge thanks to the amazing students for your enthusiasm, the TAs for your dedication, and the invited lecturers for sharing your expertise. Keep pushing the boundaries of single particle EM - excited to see what you all accomplish next!
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Miro Astore @miroastore.bsky.social · 16/03/2025
Watch out world. I can pipette now.
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Lander Lab @landerlab.bsky.social · 16/03/2025
Saturday night and the lab is in full swing as the participants of the CSHL #CryoEM course prepare for the final competition - solve the structure of a mystery protein in less than 4 hours.
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Miro Astore @miroastore.bsky.social · 17/02/2025
Come work in a great place with great people. Loads of fun projects and ideas.
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 05/02/2025
Join leaders from CCDC, ICDD, ICSD, and RCSB PDB on February 12 to learn how data management impacts future research register.gotowebinar...
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Frank Noe @franknoe.bsky.social · 06/12/2024
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...
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YC Lin @yiechanglin.bsky.social · 19/11/2024
I made a MD starter pack! Dm or reply to be added ☺️☺️ go.bsky.app/QQjPjbL
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