Applying dynamical systems theory to single-cell data can provide a detailed picture of the cellular states observed during cell fate decisions. This study presents a dynamic landscape analysis (DLA) ...

Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane adapts by measuring collagen turnover. We find that perlecan, another basement membrane protein, regulates collagen turnover to control organ shape.

The mammalian liver possesses a regenerative capacity that is unmatched by any other organ. Following injury, liver epithelial cells can proliferate or even change their identity, enabling the organ t...

Integrin adhesions allow dynamic cell-matrix interactions to regulate cell behaviour. Here, the authors reveal that tensin 1, a multidomain adaptor protein, forms condensates in cells that act as reve...

We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...

A comparative analysis of cnidarian larval morphogenesis combined with active surface theory identifies a set of mesoscale mechanical modules that predict species-specific shapes. Manipulating these m...

Chromosomal chaos rewires immune defense into tumor-promoting inflammation.

We proudly invite experts in biological physics worldwide to the International Conference on Biological Physics 2026 (ICBP 2026) in the magnificent Italian city of Genoa from June 28 to July 5, 2026

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Human metabolism; Cell biology; Biophysics

Human metabolism; Cell biology; Biophysics