Our new review explores how phase separation and biomolecular condensates link cancer-driving fusion proteins to altered gene expression and chromatin organisation.
Connecting biophysics with cancer biology.
doi.org/10.1080/2993...
#CancerResearch #Biophysics
doi.org
The roles of LLPS in transcription and chromatin organization in oncofusion-driven cancers
Liquid–liquid phase separation (LLPS) has emerged as a fundamental principle of cellular organization, enabling dynamic and reversible compartmentalization of biochemical processes without membrane...