Sign in

Chris Toseland

@christoseland.bsky.social
2.4K followers 3.2K following 88 posts

Prof. Cancer Biophysics at University of Sheffield. Investigating Nuclear Myosin, Nuclear Organisation and Mechanobiology in Cancer with single molecule Biophysics Web: Toseland-lab.com

PostsRepliesMedia
Chris Toseland @christoseland.bsky.social · 8h
Our new review explores how phase separation and biomolecular condensates link cancer-driving fusion proteins to altered gene expression and chromatin organisation. Connecting biophysics with cancer biology. doi.org/10.1080/2993... #CancerResearch #Biophysics
doi.org
The roles of LLPS in transcription and chromatin organization in oncofusion-driven cancers
Liquid–liquid phase separation (LLPS) has emerged as a fundamental principle of cellular organization, enabling dynamic and reversible compartmentalization of biochemical processes without membrane...
020
Reposted by Chris Toseland
Michael Way @drmichaelway.bsky.social · 02/10/2026
Looking for a PhD? @crick.ac.uk PhD applications for next year are open. 4 year program with lots of outstanding projects on offer. If you are interested in viral host interactions, cytoskeleton, cell bio, live cell imaging - see Way lab project + video. plz repost www.crick.ac.uk/careers-and-...
crick.ac.uk
PhD student positions
PhD projects for the 2027 Crick PhD programme.
02528
Reposted by Chris Toseland
Lennart Hilbert @lennarthilbert.bsky.social · 03/10/2026
Just gonna leave this here while it’s still hot off the press 🤩 On the Structure and Function of Transcription Bodies Maciej A. Kerlin Shivali Dongre @shivalidongre.bsky.social Eleonora Perego Martino Ugolini Nadine Vastenhouw @nvastenhouw.bsky.social www.annualreviews.org/content/jour...
annualreviews.org
On the Structure and Function of Transcription Bodies
Transcription is a key process in the life of cells. In the 1990s, cell biologists observed that transcription often takes place in discrete transcription bodies in eukaryotic nuclei, which has sparke...
055
Chris Toseland @christoseland.bsky.social · 02/10/2026
🚨 New work from our lab: ESR1 fusions don’t just alter ER signalling — they fundamentally change how the protein behaves in the nucleus. We show they form chromatin-linked condensates that reshape nuclear organisation and transcription. www.biorxiv.org/content/10.6...
1253
Chris Toseland @christoseland.bsky.social · 20/08/2026
Happy to see this work come out and it was great to work with @mkvalluru.bsky.social
020
Reposted by Chris Toseland
Mir Lab @mirlab.bsky.social · 07/06/2026
1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...
37836
Reposted by Chris Toseland
Tjian + Darzacq Lab, UC Berkeley @tjiandarzacq.bsky.social · 02/06/2026
Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵 www.science.org/doi/10.1126/...
science.org
Unstructured transcription factor interactions enable emergent specificity
How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...
17835
Reposted by Chris Toseland
Julia Lazzari-Dean @jlazzaridean.bsky.social · 12/05/2026
We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...
A cartoon overview of triplet tumbling microscopy, comparing data from bound and unbound samples.
416654
Chris Toseland @christoseland.bsky.social · 05/05/2026
Thank you for all the donations - over £2500 raised for Oscar’s charity. The kids smashed the challenged and we could not be prouder! The weather was not the kindest but we made it through 38km and over 1000m of height gain! www.justgiving.com/team/thaliaf...
0110
Reposted by Chris Toseland
James Gagnon @james-gagnon.bsky.social · 28/04/2026
Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...
A cartoon showing how a caged guide RNA poises CRISPR cleavage until release by light. Below, a cartoon of injection of "light-activated CRISPR" into the embryo, followed by activation.
211240
Chris Toseland @christoseland.bsky.social · 27/04/2026
Thalia & her sister Aneira are taking on the #NineEdgesChallenge on May 3rd for @OscarsCharity After 3 surgeries, chemo & radiotherapy for an aggressive brain tumour, Thalia is now walking to help others facing this disease. Please support 🙏 www.justgiving.com/team/thaliaf...
031
Reposted by Chris Toseland
epithelial mechanics fan club @epimechfc.bsky.social · 23/04/2026
Kalukula, Y., Ciccone, G., Mohammed, D., Procès, A., Versaevel, M., Deridoux, A., ... & Luciano, M. (2025). Unlocking the therapeutic potential of cellular mechanobiology. Science advances, 11(44), #EpithelialMechancisReview doi.org/10.1126/scia...
294
Chris Toseland @christoseland.bsky.social · 19/04/2026
Two weeks to go! Please donate! Over 100 people will be walking the 9 Edges Challenge. Please donate so we can raise vital money for Oscar’s Pediatric Brain Tumour Charity.
032
Reposted by Chris Toseland
Arnaud Krebs @arnaudkr.bsky.social · 24/03/2026
Want to know how histone marks regulate your favorite gene? Go single molecule with ChromSMF: integrated measure of chromatin accessibility and histone marks + DNA methylation, TF footprints and genotype for free! Very proud of @mpalamin.bsky.social ! @embl.org
17118
Reposted by Chris Toseland
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 08/04/2026
Our H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
26430
Reposted by Chris Toseland
Suyang Zhang @suyangzhang.bsky.social · 24/03/2026
Our lab @mrclmb.ac.uk in Cambridge is seeking a passionate PhD student to explore transcription-coupled splicing! Join our team for an exciting project to understand human gene regulation 🧬 Feel free to get in touch directly #PhD #cryoEM #biochemistry mrclmb.ac.uk/careers-and-...
0165
Chris Toseland @christoseland.bsky.social · 19/03/2026
So excellent to get this work out from our fantastic collaboration with AstraZeneca. This is a great amount of work led by joint-PhD student Noah Hitchcock! lnkd.in/ejV6QBrQ
2132
Chris Toseland @christoseland.bsky.social · 18/03/2026
Three years ago Thalia was diagnosed with a brain tumour. She had multiple surgeries, chemotherapy and radiotherapy. This year we are walking the Nine Edges Challenge to raise awareness and money for OSCAR's Paediatric Brain Tumour Charity. Please donate: www.justgiving.com/team/thaliaf...
justgiving.com
Thalia’s Team fundraising for OSCAR's Paediatric Brain Tumour Charity
Help Chris Toseland raise money to support OSCAR's Paediatric Brain Tumour Charity
0106
Reposted by Chris Toseland
Rob Klose @robklose.bsky.social · 13/03/2026
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
1106125
Reposted by Chris Toseland
David Brückner @davidbrueckner.bsky.social · 14/03/2026
How do pairs of DNA loci - such as enhancers and promoters - find each other inside the nucleus? 🤔 Most models assume the random forces driving locus motion are independent in space New preprint by @janniharju.bsky.social: this assumption fails in living cells 🧵 www.biorxiv.org/content/10.6...
311346
Reposted by Chris Toseland
Pietro Cicuta @pcicuta.bsky.social · 14/03/2026
International Congress in Biological Physics, Genova, Italy, 28 June to 3 July 2026. URGENT: submission deadline 25 March. Session topics, plenary and invited speakers: www.icbp2026.org IUPAP Physics of Life medal awarded at meeting. Spread the word - and act quickly to submit your work.
icbp2026.org
ICBP 2026
We proudly invite experts in biological physics worldwide to the International Conference on Biological Physics 2026 (ICBP 2026) in the magnificent Italian city of Genoa from June 28 to July 5, 2026
01413
Chris Toseland @christoseland.bsky.social · 13/03/2026
011
Chris Toseland @christoseland.bsky.social · 23/02/2026
Save the date! We have an exciting conference coming up next year for the UK Mechanobiology community!
02312
Chris Toseland @christoseland.bsky.social · 23/02/2026
It was great to collaborate with Javier Redondo Muñoz in this project and I am very happy to see it in press: www.cell.com/cell-reports...
0112
Chris Toseland @christoseland.bsky.social · 13/02/2026
We are very proud that Thalia has been nominated for three Yorkshire Choice awards - Please vote here: www.yorkshirechoiceawards.co.uk/vote Three years ago, Thalia was diagnosed with a devastating brain tumour. She has fought back and done her best to raise awareness and funds to support others!
1113
Reposted by Chris Toseland
Yanlan Mao @yanlanmao.bsky.social · 28/11/2025
Registration deadline 20th Dec! We have generous travel grants for early career researchers! April is a beautiful time to visit China!
1147
Reposted by Chris Toseland
Andrea Musacchio @andrea-musacchio.bsky.social · 17/11/2025
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It… 1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
nature.com
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
13714
Reposted by Chris Toseland
María Mariner @mariamafau.bsky.social · 15/11/2025
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉 Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨ #PhD #3DGenome
03637
Chris Toseland @christoseland.bsky.social · 15/11/2025
In this work we show that you don’t have to target the main players in disease….instead you identify and target what they depend on!
090
Reposted by Chris Toseland
Journal of Cell Science @jcellsci.bsky.social · 13/11/2025
We're still accepting submissions for our 'Cell Biology of the Nucleus' special issue, which is being guest edited by @abbybuch.bsky.social and Megan King (@luskinglab.bsky.social). Submission deadline: 5 January journals.biologists.com/jcs/pages/nu... #nucleus #notforprofit #freetopublish
02813
Reposted by Chris Toseland
bioRxivpreprint @biorxivpreprint.bsky.social · 14/11/2025
Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells. www.biorxiv.org/content/10.1101/202…
022
Chris Toseland @christoseland.bsky.social · 14/11/2025
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells. www.biorxiv.org/content/10.1... We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
12210
Reposted by Chris Toseland
Molecular & Clinical Cancer Medicine (MCCM) @livunicancer.bsky.social · 13/11/2025
A PhD position is available in the lab of @zech-lab.bsky.social co-supervised @christoseland.bsky.social An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project... #CellBio #SuperResolutionMicroscopy #MolecularBio #AgeingResearch #PhDOpportunity
findaphd.com
MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool, l...
122
Reposted by Chris Toseland
Steve Quinn @steve-quinn-lab.bsky.social · 31/10/2025
🔬Want to develop a blood test for dementia? A fully funded PhD position is available in our lab to probe and detect single molecules! Join our team @york.ac.uk ! Find out more & apply by 4th Dec: tinyurl.com/yt36p9tx @ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
144
Chris Toseland @christoseland.bsky.social · 05/11/2025
Please repost - Multiple PhDs available www.findaphd.com/phds/project... www.findaphd.com/phds/project... www.findaphd.com/phds/project...
13755
Chris Toseland @christoseland.bsky.social · 02/11/2025
Please Repost! Tobi Zach and I have an MRC DiMeN PhD position available! Come join us! www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool, l...
046
Chris Toseland @christoseland.bsky.social · 31/10/2025
It’s Halloween so time to make the cells scream!
0323
Reposted by Chris Toseland
Seema Grewal @seemagrewal.bsky.social · 16/07/2025
Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way! #notforprofit
02317
Reposted by Chris Toseland
Ewerslab @ewerslab.bsky.social · 10/07/2025
Phantastic review of SPT method and analysis. Great resource for every single molecule tracking enthusiast! Congratulations, @gebhardtlab.bsky.social
031
Chris Toseland @christoseland.bsky.social · 09/07/2025
Yesterday we had the School of Medicine and Population Health PGR symposium - a fantastic range of talks and posters from our students! We had excellent career sessions from Faith Nutter Howard David King and Amy Turner Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
041
Reposted by Chris Toseland
Felix Campelo @felixmendu.bsky.social · 04/07/2025
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio meetings.embo.org/event/26-org...
meetings.embo.org
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
17345
Chris Toseland @christoseland.bsky.social · 03/07/2025
Doubling up on the measurements and toys today - so great and useful to have this kit next door to each other!
040
Reposted by Chris Toseland
Alessandro Costa @costalaboratory.bsky.social · 20/06/2025
Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...
17880
Reposted by Chris Toseland
Akis (Argyris) Papantonis @akispapantonis.bsky.social · 19/06/2025
This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u A short thread follows 1/n
39439
Reposted by Chris Toseland
The University of Sheffield @sheffielduni.bsky.social · 19/06/2025
The QS World University Rankings 2026 have just been released and we’ve placed 92nd within the World Top 100! Huge congratulations and thanks to everyone in the University of Sheffield community for this achievement; from staff and students to alumni, supporters and friends around the world!
A graphic of an outline of a shield filled with photographs of students, teachers, academics and other members of the University of Sheffield community. The QS logo is prominently displayed near the bottom of the shield. Underneath is written ‘The University of Sheffield Top 100 QS World University Rankings 2026’
0199
Reposted by Chris Toseland
BIAUnit @biaunit.bsky.social · 17/06/2025
🚀 Manual mask annotation slowing you down? 💡 SAMJ is a new ImageJ/Fiji plugin using Segment Anything (SAM) for fast, interactive segmentation — no GPU needed, one-click install, real-time results. 🔬 Perfect for large biomedical images. arxiv.org/abs/2506.02783 #AI #Bioimaging #ImageJ #OpenSource
15513
Reposted by Chris Toseland
Amy Strom @dnamystrom.bsky.social · 16/06/2025
If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments www.biorxiv.org/content/10.1...
59025
Chris Toseland @christoseland.bsky.social · 06/06/2025
Back again!
150
Reposted by Chris Toseland
Emmanuel Margeat @emmanuelmargeat.bsky.social · 26/05/2025
Applications are now open for the 4th edition of the “Ecole de Physique des Houches” on Fluorescence Markers for Advanced Microscopies, a WE-Heraeus seminar. March 15th-20th 2026 Join us to learn everything you wanted to know about Fluorescent Markers for advanced microscopies.
12822
Chris Toseland @christoseland.bsky.social · 18/05/2025
Back in Harwell again for a late night reagent drop!
020