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Sylvain Gabriele

@sgabriele.bsky.social
874 followers 1K following 31 posts

Associate Professor at University of Mons Mechanobiology & Biomaterials group www.cellmechanobiology.com

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Sylvain Gabriele @sgabriele.bsky.social · 09/06/2026
🚀 New preprint on bioRxiv! How do physical boundaries shape collective cell migration? We show that geometric confinement progressively suppresses ERK signaling waves and slows collective epithelial migration by pushing tissues into a mechanically compressed state. 👉🏼 doi.org/10.64898/202...
doi.org
Geometric confinement regulates ERK signaling dynamics and collective migration
Collective cell migration is a fundamental process in morphogenesis, tissue repair, cancer invasion, and frequently occurs under geometric confinement in vivo. However, how confinement interfaces with...
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Judith Pineau @judithpineau.bsky.social · 29/04/2026
On my way back from Mons - thank you @sgabriele.bsky.social and Nikon for inviting me to this 3D imaging and mechanobiology symposium - very nice and interesting interactions (and I even got the super cool Ti2 Plushie 🔬🤩)
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David Brückner @davidbrueckner.bsky.social · 12/05/2026
Super excited to continue our collaboration with @sgabriele.bsky.social on the mechanical memory of migrating cells with an SNSF-FNRS Weave grant 🥳 How do cells retain memory of past migration events? We aim to uncover mechanisms & functional implications Background: www.nature.com/articles/s41...
nature.com
The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics
Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...
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Mechanics of Life Leverhulme Doctoral Scholarship Programme @mechanicsoflife.bsky.social · 20/02/2026
Our next #ForceTalk is with Prof Sylvain Gabriele @sgabriele.bsky.social exploring "Mechanosensing of epithelial cells: curvature, confinement and memory" 📅 4 March 2026 🕒 15:00 - 16:00 GMT Online & open to all 👉 www.kcl.ac.uk/events/force... #mechanobiology @kingsnmes.bsky.social
Background of DNA strand with logos of King's College London and the Leverhulme Trust and text 4 March 2026 Mechanosensing of epithelial cells: curvature, confinement and memory Professor Sylvain Gabriele University of Mons Force Talks Mechanics of Life Leverhulme DSP seminar series
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Sylvain Gabriele @sgabriele.bsky.social · 20/01/2026
Beautiful work from @rouxlab.bsky.social on the mechanical adaptation of epithelial tissues to multiscale curvature 👏🏻 Congrats to @marineluciano.bsky.social and all co-authors !
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Sylvain Gabriele @sgabriele.bsky.social · 14/01/2026
🚀 Very happy to see our research article “Tube feet dynamics drive adaptation in sea star locomotion” out in PNAS ! 👉🏼 www.pnas.org/doi/10.1073/... Fantastic collab with Patrick Flammang (UMONS), Sina Heydari (California State), Stanislav N. Gorb (Kiel Univ), and Eva Kanso (Univ Southern California)
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Sylvain Gabriele @sgabriele.bsky.social · 15/09/2025
The place to be 👇🏼👇🏼👇🏼
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Sylvain Gabriele @sgabriele.bsky.social · 11/09/2025
I am delighted to share that I have been awarded the Francqui Research Professorship 🥳 This achievement is above all a collective success and I sincerely thank all the researchers of my lab www.cellmechanobiology.com, past and present, for their incredible work! web.umons.ac.be/fs/fr/sylvai...
web.umons.ac.be
Sylvain Gabriele nommé « Professeur de recherche Francqui » pour la période 2025-2028 - Faculté / FS
La Fondation Francqui a sélectionné Sylvain Gabriele, chargé de cours au Département de Chimie de la Faculté des Sciences de l’UMONS, pour le prestigieux mandat de Professeur de recherche Francqui. Ce...
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Xavier Trepat @xaviertrepat.bsky.social · 01/09/2025
New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...
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Sylvain Gabriele @sgabriele.bsky.social · 25/08/2025
Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳 Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻 Enjoy the reading www.nature.com/articles/s41...
nature.com
The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics
Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...
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Pau Guillamat @pauguillamat.bsky.social · 30/06/2025
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations. The tissue morphogenesis logic, now engineered into living, programmable materials. www.biorxiv.org/content/10.1... #ActiveMatter #TissueEngineering
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Sylvain Gabriele @sgabriele.bsky.social · 04/06/2025
🔬 Excited to share our new publication in Soft Matter about hydrogel dimensionality to investigate mechanobiology. This paper with @marineluciano.bsky.social is part of the themed collection “Pioneering Investigators” - Lab website : www.cellmechanobiology.com 👉🏼 pubs.rsc.org/en/content/a...
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CellMech2025 @cellmech2025.bsky.social · 15/05/2025
@sarawickstrom.bsky.social 🎤Mechanical regulation of cell states bsky.app/profile/cell...
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Sylvain Gabriele @sgabriele.bsky.social · 14/05/2025
My lab is co-organizing the CellMech2025 conference @cellmech2025.bsky.social. I’m excited to announce that the scientific program is now online! 👉🏼 cellmech2025.org/programme/ There’s still time to submit your abstract for the Scientific Art Contest and compete for prizes !
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Sylvain Gabriele @sgabriele.bsky.social · 25/04/2025
Have you ever wondered what happens when a sea star carries a backpack full of beads? You can now find out: « Tube feet dynamics drive adaptation in sean star locomotion » www.biorxiv.org/cgi/content/...
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epithelial mechanics fan club @epimechfc.bsky.social · 16/03/2025
Luciano, M., Tomba, C., Roux, A., & Gabriele, S. (2024). How multiscale curvature couples forces to cellular functions. Nature Reviews Physics, #EpithelialMechanicsReveiw
nature.com
How multiscale curvature couples forces to cellular functions - Nature Reviews Physics
Structure and function of biological tissues are closely intertwined. This Review surveys the challenges in uncovering critical physical elements involved in the mechanical regulation of curved tissue...
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epithelial mechanics fan club @epimechfc.bsky.social · 16/03/2025
Paper 1: @sgabriele.bsky.social lab placed cells on wavy substrates (20-50µm) to demonstrate the impact of curvature on cell thickness ➡️ nudging nucleus shape ➡️ revealing mechanoadaptation.
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Benoit Ladoux @bladoux.bsky.social · 14/03/2025
Happy to share our new publication in @naturematerials.bsky.social on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats @luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉 www.nature.com/articles/s41...
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Sylvain Gabriele @sgabriele.bsky.social · 14/03/2025
🚨Only a few hours left to register for @cellmech2025.bsky.social, deadline by March 16, 2025 ! 👇🏼
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Sylvain Gabriele @sgabriele.bsky.social · 26/02/2025
Time is flying, hurry up guys !
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CellMech2025 @cellmech2025.bsky.social · 20/02/2025
⚠️⏳ There are less than 2 weeks left to submit your abstract!! Hurry up and submit here! 👇🏻 cellmech2025.org/abstracts/
media.tenor.com
a man is walking down a dirt road in a field
ALT: a man is walking down a dirt road in a field
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Sylvain Gabriele @sgabriele.bsky.social · 19/02/2025
Join us online on Tuesday, February 25, for this exciting DGZ workshop on #celladhesion and #mechanobiology 👇🏼
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Sylvain Gabriele @sgabriele.bsky.social · 17/02/2025
Check out our latest paper in Advanced Science 🥳, where we use viscoelastic hydrogels to better understand how spatial confinement and matrix viscoelasticity jointly regulate cell migration: lnkd.in/diRstW2B Great collaboration between UMONS and @giusciccone.bsky.social @manuelsalmeron.bsky.social
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Sylvain Gabriele @sgabriele.bsky.social · 04/02/2025
The 10th edition of CellMech 2025, which my lab is co-organizing in Sept-Oct ‘25, has officially opened the abstract submission portal! cellmech2025.org We are thrilled to announce our amazing list of keynote speakers, who will help us to make this conference a major event in mechanobiology!
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Julia Eckert @juliaeckert.bsky.social · 29/01/2025
Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems! www.biorxiv.org/content/10.1... Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris Any 3D systems?👇
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Roux Lab, Geneva @rouxlab.bsky.social · 20/01/2025
Yamini @yamini-ravichan.bsky.social changed the topology of Hydra to show that actin orientational defects of Hydra induce the full program of head regeneration: www.science.org/doi/10.1126/... Mechanics controls development! Thanks to Dan Pearce, Karsten Kruse, Matthias Vogg & Brigitte Galliot.
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fspasqualini.bsky.social @fspasqualini.bsky.social · 17/01/2025
And here is pre-print 2/2! *HYDRA: HYdrogel Dispensing with Robotic Automation* - a scalable solution for drug testing. Great work by 1st author @eloisa_torchia and team with help from the labs of @sgabriele.bsky.social Elisa Cimetta and Johan Lind biorxiv.org/content/10.1...
biorxiv.org
HYDRA: HYdrogel Dispensing with Robotic Automation for high throughput drug testing
The poor predictivity of traditional cell culture platforms hampers drug research and development efficiency. While organoids and organs-on-chip mitigate this problem by introducing biomimetic in-vitr...
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Sylvain Gabriele @sgabriele.bsky.social · 13/01/2025
Really looking forward to visit the Salmeron’s lab at the Institute for Bioengineering of Catalonia @ibecbarcelona.eu at Barcelona tomorrow ! Thanks to @manuelsalmeron.bsky.social and @giusciccone.bsky.social for their kind invitation !
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Sylvain Gabriele @sgabriele.bsky.social · 21/12/2024
Season’s greetings and happy holidays from the Mechanobiology & Biomaterials group at the University of Mons
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Andy Moore @aaandmoore.bsky.social · 18/12/2024
Really bummed to have missed ASCB this year due to some last-minute circumstances, but excited that our manuscript describing an IF disassembly tool will (hopefully) be posted soon. Here's a movie of vimentin color-coded by orientation.
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Sylvain Gabriele @sgabriele.bsky.social · 11/12/2024
Super cool study 🤩
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CellMech2025 @cellmech2025.bsky.social · 10/12/2024
👋Hello #mechanobiology community in 🦋! This is the official account of the 10th Edition of the Cell Mech conference! 🔧We will soon announce the invited speaker list! Visit our website, subscribe to the mailing list, and follow us!: cellmech2025.org 😍Join us in Leuven 2025!
cellmech2025.org
The organizing committee, Sylvain Gabriele, Marine Luciano, Jorge Barrasa Fano, Yohalie Kalukula, Bart Smeets, Apeksha Shapeti, Hans Van Oosterwyck
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Sylvain Gabriele @sgabriele.bsky.social · 10/12/2024
🤩 Very proud of my PhD student Yohalie Kalukula who has been selected by The Rising Stars in Soft and Biological Matter Symposium hosted by the UChicago and UCSD MRSECs👏🏻 You can register to watch her talk on the mechanical memory of confined migrating cells👇🏼 mrsec.uchicago.edu/about-us/ris...
mrsec.uchicago.edu
Rising Stars 2024 | Chicago Materials Research Center
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Pablo J. Sáez @pjsaez.bsky.social · 06/12/2024
As promised, here a fast acquisition of a migrating cell videoed under a microscopy, look those membrane dynamics @ the leading edge ! Bonus: nuclear deformation once the cell rear snaps. (Fluo nucleus, for the #fluorescencefriday) @focalplane.bsky.social @cellcommlab.bsky.social #CellMigration 🧪🔬
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Xavier Trepat @xaviertrepat.bsky.social · 03/12/2024
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
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Stella Hurtley @smhsci.bsky.social · 29/11/2024
Check out a new paper just published in @science.org www.science.org/doi/10.1126/...
science.org
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we ...
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Sylvain Gabriele @sgabriele.bsky.social · 27/11/2024
Great article in the French journal Le Monde by @manuelthery.bsky.social about the self-organization of microtubules and molecular motors 👇🏼 www.lemonde.fr/sciences/art...
lemonde.fr
Comment les microtubules s’auto-organisent dans les cellules
Une équipe de chercheurs a mis en évidence le fonctionnement en réseau de ces filaments tubulaires, éléments essentiels du cytosquelette.
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Sylvain Gabriele @sgabriele.bsky.social · 25/11/2024
Join us next week in London for the conference « Mechanobiology Shaping Life » organized at the Institute of Physics iop.eventsair.com/msl2025/ 👇🏼
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Benoit Ladoux @bladoux.bsky.social · 24/11/2024
I am delighted to share our new preprint in which we reveal the crucial role for mechanical forces in myoblast fusion. Great work from Yoann, Sushil and Aleksandra and great collaboration with Christophe Marcelle and Amin Doostmohammadi! www.biorxiv.org/content/10.1...
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Benoit Ladoux @bladoux.bsky.social · 21/11/2024
Large-scale collective motion of epithelial cells not as a fluid, but as a polar elastic solid. Our new study posted on Biorxiv: www.biorxiv.org/content/10.1...
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Sylvain Gabriele @sgabriele.bsky.social · 21/11/2024
Pre-announcing the 10th Biennial European CellMech conference organized in Leuven 🇧🇪 from September 30th to October 3rd, 2025. cellmech2025.org Save the date !
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