Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

Mouse embryonic stem cells remain connected by bridges for hours after cell division. In this paper, Kodba et al. show that a high Aurora B activity at the bridge leads to microtubule stabilization. S...

Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...

How the environment regulates neuronal maturation during brain development is poorly understood. Here, Kreysing et al. identify brain stiffness as a key factor and determine a mechanotransduction path...

The shaping of developing tissues is often thought of in terms of the chemical gradients that influence tissue morphology, and the mechanical landscape which results in bends, kinks and folds in the t...

Tissue regeneration is a dynamic process requiring coordinated cell fate decisions to restore structure and function. For instance, the tips of human and rodent digits fully regrow after amputation, a...