Nature Reviews Immunology, Published online: 25 August 2026; doi:10.1038/s41577-026-01352-9Checkpoint inhibitors, CAR T cells and bispecific T cell engagers have demonstrated the transformative potential of cancer immunotherapy. However, progress has slowed as efforts have focused on replicating PD-(L)1 blockade successes, highlighting the need for deeper understanding of human cancer immunity.

Nature Reviews Immunology - Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen...

Multiple sclerosis (MS), is an autoimmune disease of the central nervous system (CNS), characterized by demyelination and neuronal loss, along with immune cell brain infiltration and inflammation.

This study dissects the individual contributions of the different components of mRNA vaccines to immune responses. Nucleoside-modified mRNA promotes the production of type I interferons that act on de...

Botnar Institute of Immune Engineering - BIIE has a job opening for Doctoral studentships, Molecular Mucosal Immunology Group in Zürich (published: 29.10.2025). Apply now or check the other available...

Interact-omics, a high-throughput cytometry-based framework, resolves the cellular interaction landscape.

TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.

Nature - Precursors of exhausted T cells are preemptively formed in acute infection

Highlighted Article: Delayed activation of the T-cell lineage commitment regulator Bcl11b in mouse thymic progenitors due to distal enhancer deletion reduces T-cell output and increases Zbtb16-driven ...

UMAP is a powerful tool for exploratory data analysis, but without a clear understanding of how it works, it can easily lead to confusion and misinterpretation.

ESO-T01 is the first in vivo BCMA CAR-T candidate to reach the clinical stage Early clinical data are expected in second half of 2025 MONT-SAINT-GUIBERT, Belgium, Dec. 11, 2024 (GLOBE NEWSWIRE) -- Eso...

To engineer cells that can specifically target the central nervous system (CNS), we identified extracellular CNS-specific antigens, including components of the CNS extracellular matrix and surface mol...

The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4+ T cells in mouse autoimmune diabetes may circ...

KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.