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Paul Rennert

@pdrworld.bsky.social
390 followers 153 following 118 posts

Biotech exec, pro drug developer. Amateur everything else: COOKING, ferments, preserving, charcuterie, fishing, gardening, weightlifting, BIRDER, photography, physics, literature, writer, history, DAD

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Paul Rennert @pdrworld.bsky.social · 30/09/2025
birders---> maybe a good winter coming for northern finches and friends finchnetwork.org/winter-finch... #birders #birding #massbird
finchnetwork.org
Winter Finch Forecast 2025-2026 - FINCH RESEARCH NETWORK
By Tyler Hoar Featured Post Photo: ©David Turgeon GENERAL FORECAST It looks to be a flight year for many species in Eastern Canada. With mostly very poor crops in the boreal forest from central Quebec...
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Paul Rennert @pdrworld.bsky.social · 15/08/2025
lovely writeup at BBC #Seurat bbc.com/culture/arti...
bbc.com
'As urgent and relevant today as it ever was': The radical manifesto hidden in Georges Seurat's 1884 masterpiece
Georges Seurat's once-mocked painting Bathers at Asnières is both an "exquisite distillation of the very essence of summer" and "a modern wonder in the art of seeing".
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Paul Rennert @pdrworld.bsky.social · 15/08/2025
A very interesting bispecific ADC highlighted today by @JacobPlieth on X - oncologypipeline.com/apexonco/bri... while this discussion is focused on lung cancer, the first approval for iza-bren likely in nasopharyngeal carcinoma $BMY #SystImmune
oncologypipeline.com
Bristol's third pivotal iza-bren study
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Paul Rennert @pdrworld.bsky.social · 25/07/2025
odd dynamic between clean energy needs and protecting ocean/avian ecosystems hard to choose a side? yep... chng.it/ThgpyJY2Pw
chng.it
This campaign needs you now
Ban the over-use of single use plastics.
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Paul Rennert @pdrworld.bsky.social · 22/07/2025
Mars, duh.
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Paul Rennert @pdrworld.bsky.social · 22/07/2025
for #biotech and advanced therapeutics followers, a cool paper here: doi.org/10.1016/j.me...
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Paul Rennert @pdrworld.bsky.social · 08/07/2025
Esobiotec's in vivo CAR-T data out in Lancet, n=4, multiple myeloma. These are the data that drove the $AZN acquisition, showing that the in vivo CAR-T results were equal to the ex vivo CAR-T results from Pregene w the same BCMA-CAR www.thelancet.com/journals/lan...
thelancet.com
In-vivo B-cell maturation antigen CAR T-cell therapy for relapsed or refractory multiple myeloma
Chimeric antigen receptor (CAR) T-cell therapy has shown impressive efficacy in treating relapsed or refractory multiple myeloma. Nonetheless, its availability is substantially restricted by complex m...
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Paul Rennert @pdrworld.bsky.social · 08/07/2025
Concentra goes shopping again, adds CARGO to its market basket finance.yahoo.com/news/cargo-t... Cargo, IGM, Elevation Oncology, Kronos Bio, Allakos
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Paul Rennert @pdrworld.bsky.social · 07/07/2025
HER3 activation and overexpression in cancers makes this antigen an attractive target for antibody therapeutics ---> a rapidly expanding drug development landscape has emerged sugarconebiotech.com/insights
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Paul Rennert @pdrworld.bsky.social · 06/07/2025
In the inflammatory #fibrosis space, $PLRX stopped development of bexotegrast avb6/avb1 inhibitor for the treatment of IPF "due to worsening of IPF and acute IPF exacerbation, respiratory-related hospitalization, and/or all-cause mortality" (27 June 2025). Yikes.
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Paul Rennert @pdrworld.bsky.social · 21/06/2025
tgif. goosebumps at this Wharf Rat, starts @ 10:28 www.youtube.com/watch?v=I1FV... the wheel is nice too, but man... 'i got up and wandered'
youtube.com
15. The Wheel -} Wharf Rat - Grateful Dead - 5/7/77 Boston Garden, Boston, MA - U31DoD 2012 Edition
YouTube video by NuttyRiv3r
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Paul Rennert @pdrworld.bsky.social · 20/06/2025
quick series on emerging #cancer targets w updates post #ASCO25 from the biopharma/venture capital consultancy experts - sugarconebiotech.com #biotech #bioblue www.sugarconebiotech.com/insights/goo...
sugarconebiotech.com
Good things come in 3s — SugarCone Biotech
DLL3, B7H3 and Her3 are compelling tumor antigens to target with cancer therapeutics. They have interesting patterns of expression in different cancer indications; thus, diverse therapies for attackin...
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Paul Rennert @pdrworld.bsky.social · 12/06/2025
June snacks
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Paul Rennert @pdrworld.bsky.social · 07/06/2025
Remarkable - Swallow-Tailed Kites are using a highly localized cicada emergence as an excuse to hang around and possibly nest in Mashpee MA, way north of their closest haunts in N.Carolina and FL #birding #birdblue
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Paul Rennert @pdrworld.bsky.social · 20/05/2025
A quick note of thanks to Esobiotec's management and Board of Directors as the AstraZeneca acquisition is now completed. Our job is done with this happy exit, and so the current Board, myself included, disperses. Its a bittersweet moment for me. #biotech #biosky www.astrazeneca.com/media-centre...
astrazeneca.com
Acquisition of EsoBiotec completed
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Paul Rennert @pdrworld.bsky.social · 17/04/2025
ln early March I talked about the bispecific antibody landscape in IAI, specifically for atopic dermatitis and asthma. This remains a red hot area #biosky #biotech ... and we've added analysts to keep up the pace. See sugarconebiotech.com/insights/nov...
sugarconebiotech.com
Novel bispecific antibodies – Part 2 – immunology, asthma and atopic dermatitis — SugarCone Biotech
In 1986 - nearly 40 years ago - the first antibody therapy was FDA-approved: muromonab-CD3 (Orthoclone OKT3®), a murine monoclonal antibody targeting human CD3 expressed on T cells. This therapy was u...
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Paul Rennert @pdrworld.bsky.social · 09/04/2025
#biotech #biosky
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Reposted by Paul Rennert
Paul Rennert @pdrworld.bsky.social · 08/04/2025
Here we look at the state of In Vivo CAR T cell technology and companies, post Astra Zeneca's billion dollar Esobiotec acquisition and amid biotech's financing woes: www.sugarconebiotech.com/insights
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Paul Rennert @pdrworld.bsky.social · 08/04/2025
Here we look at the state of In Vivo CAR T cell technology and companies, post Astra Zeneca's billion dollar Esobiotec acquisition and amid biotech's financing woes: www.sugarconebiotech.com/insights
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Paul Rennert @pdrworld.bsky.social · 03/04/2025
Bye-Bei TIGIT - a lesson in the dangers of mediocre science butting up against the challenges of complex ligand/receptor interactions, FcReceptor biology, and cancer resistance mechanisms Beigene news via #ApexOnco www.oncologypipeline.com/apexonco/bei...
oncologypipeline.com
BeiGene bows out of TIGIT
AstraZeneca and GSK/iTeos's odysseys get a little lonelier still.
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Paul Rennert @pdrworld.bsky.social · 02/04/2025
haven't listened to this '77 very much, it's blistering www.youtube.com/watch?v=wPgE...
youtube.com
Grateful Dead - Memorial Coliseum (Tuscaloosa, AL) 05/17/1977 (Complete Show)
YouTube video by Jack Straw From Wichita
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Paul Rennert @pdrworld.bsky.social · 28/03/2025
omg it worked! #bispecifics #oncology #Tcells www.sugarconebiotech.com/insights/ale... cc www.aletabio.com
sugarconebiotech.com
Aleta’s Novel T Cell Engagers — SugarCone Biotech
Aleta Bio recently announced that their scientists have created, characterized and validated novel classes of Immune Cell Engager therapeutics including T Cell Engagers (TCE) and CAR T Cell Engagers (...
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Paul Rennert @pdrworld.bsky.social · 25/03/2025
T CELL ENGAGER PROTEINS WITH BUILT IN COSTIMULATORY DOMAINS THAT TURN TUMOR CELLS INTO IMMUNE CELL MIMICS AND TRIGGER IMMUNE SYNAPSE SIGNALING ... www.aletabio.com/blog-1-1/ale... @BioAleta
aletabio.com
Aleta’s Novel T Cell Engagers — Aleta Biotherapeutics
By Paul Rennert Aleta’s CSO and Co-Founder Paul Rennert talks about the company’s recent announcement that their scientists created, characterized, and validated novel classes of Immune Cell Engager...
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Paul Rennert @pdrworld.bsky.social · 24/03/2025
Our most potent T cell bispecifics leverage natural T cell immunology to kill cancer cells ... www.sugarconebiotech.com/insights/ale... proprietary technology that works just as well with CAR T engager proteins #aletabio #bispecifics #CARTcells
sugarconebiotech.com
Aleta’s Novel T Cell Engagers — SugarCone Biotech
Aleta Bio recently announced that their scientists have created, characterized and validated novel classes of Immune Cell Engager therapeutics including T Cell Engagers (TCE) and CAR T Cell Engagers (...
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Paul Rennert @pdrworld.bsky.social · 18/03/2025
Whoa #biotech $CRGX implodes.
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Paul Rennert @pdrworld.bsky.social · 18/03/2025
news for #bioblue #biotech www.theguardian.com/business/202...
theguardian.com
AstraZeneca pays up to $1bn for biotech firm ‘that could transform cell therapy’
UK pharma group acquires Belgium’s EsoBiotec as it announces EU has approved Imfinzi lung cancer drug
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Paul Rennert @pdrworld.bsky.social · 15/03/2025
from last year, a blockbuster- The EBMT Handbook. Hematopoietic Cell Transplantation and Cellular Therapies" bit.ly/41n3IKb
bit.ly
The EBMT Handbook
This Open Access 8th ed. of the EBMT book addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy
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Paul Rennert @pdrworld.bsky.social · 13/03/2025
and we provide some broader #biotech #bioblue context www.sugarconebiotech.com/insights/pd1...
sugarconebiotech.com
PD1 x VEGF bispecific landscape: examining Hope versus Hype. — SugarCone Biotech
There were waves of interest in this therapeutic space at ASCO in June 2024 and around the JP Morgan healthcare conference in January 2025. Here we take a look at the hope and the hype behind the PD1/...
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Paul Rennert @pdrworld.bsky.social · 13/03/2025
the ivonescimab clinical data have published in @thelancet.bsky.social www.thelancet.com/journals/lan... and they added some great commentary
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Paul Rennert @pdrworld.bsky.social · 12/03/2025
maybe $LEGN can test the thesis that there is only bad news for #biotech stocks ... they think 10,000 patients will receive CARVYKTI in 2025 ... looking at $2B in sales for this year
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Paul Rennert @pdrworld.bsky.social · 10/03/2025
interesting Phase 3 results for rocatinlimab, an anti-OX40 antagonist antibody for atopic dermatitis. This therapeutic hit on all endpoints... $AMGN an anti-OX40L antibody also coming from $SNY www.amgen.com/newsroom/pre...
amgen.com
AMGEN AND KYOWA KIRIN PROVIDE TOP-LINE RESULTS FROM ROCATINLIMAB PHASE 3 IGNITE STUDY IN ADULTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS
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Paul Rennert @pdrworld.bsky.social · 07/03/2025
how to survive reviewing those papers you promised to review. #protip for #biotech and #academics archive.org/details/ttb2...
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Paul Rennert @pdrworld.bsky.social · 05/03/2025
I use youtube for short videos on cooking, walkabouts with the dog, and primers on biotech and drug development here's "cooking while the dog sleeps" resulting in a very nice dish #dashi #bokchoi #rumcure #bacon youtu.be/7356YW9CNIs
youtu.be
Dog and Cooking SD 480p
YouTube video by Paul Rennert
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Paul Rennert @pdrworld.bsky.social · 03/03/2025
hey #biotech this week was the annual meeting of AAAAI so we are talking asthma and atopic dermatitis In honor of AAAAI week we're talking about asthma and atopic dermatitis - the future is bispecific! www.sugarconebiotech.com/insights/nov...
sugarconebiotech.com
Novel bispecific antibodies – Part 2 – immunology, asthma and atopic dermatitis — SugarCone Biotech
In 1986 - nearly 40 years ago - the first antibody therapy was FDA-approved: muromonab-CD3 (Orthoclone OKT3®), a murine monoclonal antibody targeting human CD3 expressed on T cells. This therapy was u...
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Paul Rennert @pdrworld.bsky.social · 03/03/2025
A bit more #bioblue #biotech #oncology news from aletabiotherapeutics.com - we've invented a remarkable way to boost the functionality of T Cell Engager proteins (TCE) by making tumor cells look more like an immune cell. The "engaged" T cells just LOVE the embrace. www.nature.com/articles/d43...
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Paul Rennert @pdrworld.bsky.social · 02/03/2025
hey #bioblue --- in a time of simply ridiculous copycat drug development we found a few examples of real innovation. Part 1 - novel bispecific therapeutics in oncology. Posted only at sugarconebiotech.com. www.sugarconebiotech.com/insights/nov...
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Paul Rennert @pdrworld.bsky.social · 02/03/2025
Arcane. Amazing.
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Paul Rennert @pdrworld.bsky.social · 02/03/2025
Lovely book.
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Paul Rennert @pdrworld.bsky.social · 27/02/2025
Paul D. Rennert @PDRennert · coming soon to the sugarconebiotech.com blog - interesting bispecific programs found in company pipelines eg. $CMPX $BCAX and more and coming soon to the aletabio.com blog - a very novel class of engager molecules
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Paul Rennert @pdrworld.bsky.social · 23/02/2025
Trump just added the CFIUS nail to the $XBI coffin. #biotech #China #bioblue
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Reposted by Paul Rennert
Paul Rennert @pdrworld.bsky.social · 08/01/2025
Very nice in vivo CAR T news from Esobiotec in the EU: www.morningstar.com/news/globe-n... disclosure: BOD member
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Reposted by Paul Rennert
Paul Rennert @pdrworld.bsky.social · 08/01/2025
When you're dictating because of chronic wrist tendinitis due to chronic PowerPoint production but the dog is staring at you: "Do you wanna go out or you hungry which is it you gotta tell me I can’t read your flipping mind" is probably inappropriate in the middle of an invention disclosure
dog
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Reposted by Paul Rennert
Paul Rennert @pdrworld.bsky.social · 14/01/2025
clever idea, once pursued by Xios, we worried about potential autoimmune toxicities however
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Reposted by Paul Rennert
Paul Rennert @pdrworld.bsky.social · 17/01/2025
A blistering Mountain Jam, courtesy of The Tedeshi Trucks Band and @archive.org cc @gilman.bsky.social @bourkepr.bsky.social archive.org/details/ttb2...
archive.org
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Reposted by Paul Rennert
Paul Rennert @pdrworld.bsky.social · 27/01/2025
We think that the copycat stampede in PD-1 x VEGF pathway bispecifics betrays weakness in innovation and ignores looming competition. cc sugarconebiotech.com
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Reposted by Paul Rennert
Paul Rennert @pdrworld.bsky.social · 29/01/2025
CARGO runs aground investors.cargo-tx.com/news-release... #bioblue #bluebio #biotech
investors.cargo-tx.com
CARGO Therapeutics to Discontinue FIRCE-1 Phase 2 Study of Firi-cel; Advances Remaining Programs While Evaluating Strategic Options | CARGO Therapeutics, Inc.
CARGO elects to discontinue FIRCE-1, a Phase 2 clinical study of firicabtagene autoleucel (firi-cel) 1 ; Company believes results do not support a competitive benefit-risk profile for patients. CARGO ...
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Reposted by Paul Rennert
Paul Rennert @pdrworld.bsky.social · 05/02/2025
Another bell tolls for TILs. #biosky #biotech ir.turnstonebio.com/news-release...
ir.turnstonebio.com
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Reposted by Paul Rennert
Paul Rennert @pdrworld.bsky.social · 16/02/2025
VEGF/PD-1 pathway bispecifics: Hype versus Hope www.sugarconebiotech.com/insights/pd1...
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Paul Rennert @pdrworld.bsky.social · 16/02/2025
VEGF/PD-1 pathway bispecifics: Hype versus Hope www.sugarconebiotech.com/insights/pd1...
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Paul Rennert @pdrworld.bsky.social · 05/02/2025
Another bell tolls for TILs. #biosky #biotech ir.turnstonebio.com/news-release...
ir.turnstonebio.com
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