A new study from the Dushek and van der Merwe labs demonstrates a novel strategy to reduce dangerous off-target effects in engineered T cell therapies.

This study shows that T cell cross-reactivity is influenced by the co-signalling molecules CD5, CD8 and CD4, and that cytotoxic T cells with a CD8→CD4 co-receptor switch show reduced cross-reactivity ...

imageimageThe OT-I mouse T-cell receptor (TCR) is thought to perfectly discriminate between lower-affinity self- and higher-affinity foreign antigen-MHC complexes. This study shows OT-I TCR to exhibit imperfect discrimination and to be activated ...

This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...

Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…

Prime Minister Justin Trudeau says Canada is joining the European Union's $100-billion scientific research program, called Horizon Europe.